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Article: Use it or lose it: Establishment and persistence of T cell memory

TitleUse it or lose it: Establishment and persistence of T cell memory
Authors
KeywordsCD4 T lymphocytes +
CD8T cells
Influenza a virus
T cell memory
Aged
Issue Date2012
Citation
Frontiers in Immunology, 2012, v. 3, n. NOV How to Cite?
AbstractPre-existing T cell memory provides substantial protection against viral, bacterial, and parasitic infections.The generation of protective T cell memory constitutes a primary goal for cell-mediatedvaccines, thus understanding the mechanistic basis of memory development and maintenance are of major importance. The widely accepted idea that T cell memory pools are directly descended from the effector populations has been challenged by recent reports that provide evidence for the early establishment of T cell memory and suggest that the putative memory precursorT cells do not undergo full expansion to effector status. Moreover, it appears that once the memory T cells are established early in life, they can persist for the lifetime of an individual.This is in contrast to the reported waning of naïveT cell immunity with age.Thus, in the elderly, immune memory that was induced at an early age may be more robust than recently induced memory, despite the necessity for long persistence.The present review discusses the mechanisms underlying the early establishment of immunological memory and the subsequent persistence of memoryT cell pools in animal models and humans. © 2012 Kedzierska, Valkenburg, Doherty.
Persistent Identifierhttp://hdl.handle.net/10722/241155

 

DC FieldValueLanguage
dc.contributor.authorKedzierska, Katherine-
dc.contributor.authorValkenburg, Sophie A.-
dc.contributor.authorDoherty, Peter C.-
dc.contributor.authorDavenport, Miles P.-
dc.contributor.authorVenturi, Vanessa-
dc.date.accessioned2017-05-26T03:36:58Z-
dc.date.available2017-05-26T03:36:58Z-
dc.date.issued2012-
dc.identifier.citationFrontiers in Immunology, 2012, v. 3, n. NOV-
dc.identifier.urihttp://hdl.handle.net/10722/241155-
dc.description.abstractPre-existing T cell memory provides substantial protection against viral, bacterial, and parasitic infections.The generation of protective T cell memory constitutes a primary goal for cell-mediatedvaccines, thus understanding the mechanistic basis of memory development and maintenance are of major importance. The widely accepted idea that T cell memory pools are directly descended from the effector populations has been challenged by recent reports that provide evidence for the early establishment of T cell memory and suggest that the putative memory precursorT cells do not undergo full expansion to effector status. Moreover, it appears that once the memory T cells are established early in life, they can persist for the lifetime of an individual.This is in contrast to the reported waning of naïveT cell immunity with age.Thus, in the elderly, immune memory that was induced at an early age may be more robust than recently induced memory, despite the necessity for long persistence.The present review discusses the mechanisms underlying the early establishment of immunological memory and the subsequent persistence of memoryT cell pools in animal models and humans. © 2012 Kedzierska, Valkenburg, Doherty.-
dc.languageeng-
dc.relation.ispartofFrontiers in Immunology-
dc.subjectCD4 T lymphocytes +-
dc.subjectCD8T cells-
dc.subjectInfluenza a virus-
dc.subjectT cell memory-
dc.subjectAged-
dc.titleUse it or lose it: Establishment and persistence of T cell memory-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.3389/fimmu.2012.00357-
dc.identifier.scopuseid_2-s2.0-84874230727-
dc.identifier.volume3-
dc.identifier.issueNOV-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1664-3224-

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