File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Accurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan.

TitleAccurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan.
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S69, abstract no. O-3 How to Cite?
AbstractBackground: Since CT scan has been notorious for its low sensitivity for small HCC, it gave a poor predict of Milan criteria before liver transplantation.The objective of this study is to evaluate whether dual tracer PET CT is a more sensitive and accurate tumour staging method. Method: Between January 2004 and September 2009, we retrospectively reviewed fi fty-eight patients who had dual tracer whole body PET scan before operation. In this group of patients, 30 patients underwent hepatectomy and 28 underwent liver transplantation. All patients were found to have HCC proven by pathological assessment. The result of HCC staging and Milan criteria according to CT scan, 18F-FDG PET, 18F-FDG and 11C-acetate PET CT were compared with the pathological result after operation. Results: In this study, the sensitivity of 18F-FDG PET, CT scan, 18F-FDG and 11C-acetate PET CT were 60%, 62% and 96% respectively. 25 patients had HCC inside Milan criteria and 33 patients had HCC out of Milan criteria. Using CT scan alone, the prediction for within and outside pathological Milan criteria was 52% and 70% (P=1). Using 18F-FDG PET alone, the prediction for within and outside pathological Milan criteria was 56% and 63% (P=0.538). Using 18F-FDG and 11C-acetate PET CT, the prediction for within and outside pathological Milan criteria was 100% and 93% (P=1). Using 18F-FDG PET alone, 35 patients were found defi nitive for HCC, only15 patients had a same tumour staging when compared with the fi nal pathology (p=0.048). Using CT scan alone, 36 patients were found defi nitive for HCC, only 9 patients had a same tumour staging (p=0.024). Using 18F-FDG and 11C-acetate PET CT, 56 patients were found defi nitive for HCC, and 41 patients had a same tumour staging (p=0.262). 5 patients had additional pathology detected by dual tracer PET CT. Conclusion: 18F-FDG and 11C-acetate PET CT provide better prediction for Milan criteria and tumour staging at pathological examination when compared to CT scan alone. It is a good revaluation method for patient selection before liver transplantation
DescriptionPlenary Session I
Persistent Identifierhttp://hdl.handle.net/10722/241098
ISSN
2017 Impact Factor: 3.756
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorCheung, TT-
dc.contributor.authorChan, SC-
dc.contributor.authorChok, KSH-
dc.contributor.authorNg, KKC-
dc.contributor.authorChan, ACY-
dc.contributor.authorSharr, WW-
dc.contributor.authorPoon, RTP-
dc.contributor.authorLo, CM-
dc.contributor.authorFan, ST-
dc.date.accessioned2017-05-24T07:22:53Z-
dc.date.available2017-05-24T07:22:53Z-
dc.date.issued2010-
dc.identifier.citationInternational Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S69, abstract no. O-3-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/241098-
dc.descriptionPlenary Session I-
dc.description.abstractBackground: Since CT scan has been notorious for its low sensitivity for small HCC, it gave a poor predict of Milan criteria before liver transplantation.The objective of this study is to evaluate whether dual tracer PET CT is a more sensitive and accurate tumour staging method. Method: Between January 2004 and September 2009, we retrospectively reviewed fi fty-eight patients who had dual tracer whole body PET scan before operation. In this group of patients, 30 patients underwent hepatectomy and 28 underwent liver transplantation. All patients were found to have HCC proven by pathological assessment. The result of HCC staging and Milan criteria according to CT scan, 18F-FDG PET, 18F-FDG and 11C-acetate PET CT were compared with the pathological result after operation. Results: In this study, the sensitivity of 18F-FDG PET, CT scan, 18F-FDG and 11C-acetate PET CT were 60%, 62% and 96% respectively. 25 patients had HCC inside Milan criteria and 33 patients had HCC out of Milan criteria. Using CT scan alone, the prediction for within and outside pathological Milan criteria was 52% and 70% (P=1). Using 18F-FDG PET alone, the prediction for within and outside pathological Milan criteria was 56% and 63% (P=0.538). Using 18F-FDG and 11C-acetate PET CT, the prediction for within and outside pathological Milan criteria was 100% and 93% (P=1). Using 18F-FDG PET alone, 35 patients were found defi nitive for HCC, only15 patients had a same tumour staging when compared with the fi nal pathology (p=0.048). Using CT scan alone, 36 patients were found defi nitive for HCC, only 9 patients had a same tumour staging (p=0.024). Using 18F-FDG and 11C-acetate PET CT, 56 patients were found defi nitive for HCC, and 41 patients had a same tumour staging (p=0.262). 5 patients had additional pathology detected by dual tracer PET CT. Conclusion: 18F-FDG and 11C-acetate PET CT provide better prediction for Milan criteria and tumour staging at pathological examination when compared to CT scan alone. It is a good revaluation method for patient selection before liver transplantation-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.titleAccurate Prediction of Milan Criteria: The Role of Dual Tracer 18F-FDG and 11C-Acetate PET-CT Scan.-
dc.typeConference_Paper-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailSharr, WW: wwsharr@hku.hk-
dc.identifier.emailPoon, RTP: poontp@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityPoon, RTP=rp00446-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityFan, ST=rp00355-
dc.identifier.doi10.1002/lt.22086-
dc.identifier.volume16-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS69-
dc.identifier.epageS69-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats