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Conference Paper: Serial early post-intensity-modulated radiation therapy (IMRT) undetectable plasma EBV DNA to predict long-term outcomes in nasopharyngeal cancer (NPC)

TitleSerial early post-intensity-modulated radiation therapy (IMRT) undetectable plasma EBV DNA to predict long-term outcomes in nasopharyngeal cancer (NPC)
Authors
Issue Date2015
PublisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/
Citation
The 51st Annual Meeting of the American Society of Clinical Oncology (ASCO 2015), Chicago, IL., 29 May-2 June 2015. In Journal of Clinical Oncology, 2015, v. 33 n. 15 suppl., abstract no. 6007 How to Cite?
AbstractBACKGROUND: The relationship between early undetectable plasma EBV DNA after intensity-modulated radiation therapy (IMRT) for NPC and long-term survival remains unclear. Early post-IMRT undetectable plasma EBV DNA is a proposed efficacy endpoint which warrants investigation as a predictor of long-term survival. We prospectively explored the predictive power of post-IMRT 8th week and 6th month undetectable plasma EBV DNA for 3-year survival outcomes in patients with non-metastatic NPC. METHODS: Two hundred and sixty patients with non-metastatic NPC were treated with IMRT +/- concurrent /induction/adjuvant platinum-based chemotherapy. Plasma EBV DNA was taken at diagnosis and then 8 weeks and 6 months after IMRT. Time-dependent Receiver-Operating Characteristics (TD-ROC) were used to obtain Cτ indices. Cox regression models identified interaction between undetectable post-IMRT 8th week and 6th month plasma EBV DNA and outcomes including progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). RESULTS: A strong relationship was shown between post-IMRT 8th week and 6th month undetectable plasma EBV DNA with PFS, CSS and OS (TD-ROC revealing higher Cτ indices for stage IVA–B compared to stage I–III). Cox regression showed that post-IMRT 8th week and 6th month undetectable plasma EBV DNA were prognostic of PFS (p < 0.001 and p < 0.001, respectively), CSS (p = 0.006 and p = 0.004, respectively) and OS (p = 0.039 and p = 0.012, respectively). Baseline plasma EBV DNA was not prognostic of any survival outcome. CONCLUSIONS: Our study showed a strong relationship between post-IMRT 8th week and 6th month undetectable plasma EBV DNA and 3-year survival outcomes. This suggested the use of early plasma EBV DNA as a predictor of survival in this setting.
DescriptionOral Abstract Session - Head and Neck Cancer
Persistent Identifierhttp://hdl.handle.net/10722/241006
ISSN
2015 Impact Factor: 20.982
2015 SCImago Journal Rankings: 9.204

 

DC FieldValueLanguage
dc.contributor.authorLee, VHF-
dc.contributor.authorKwong, DLW-
dc.contributor.authorLeung, TW-
dc.contributor.authorChoi, CW-
dc.contributor.authorNg, SCY-
dc.contributor.authorLam, KO-
dc.contributor.authorSze, CKH-
dc.contributor.authorTong, CC-
dc.contributor.authorHo, PYP-
dc.contributor.authorChan, WLW-
dc.contributor.authorWong, LS-
dc.contributor.authorLeung, DKC-
dc.contributor.authorChan, ASY-
dc.contributor.authorChan, FT-
dc.contributor.authorLau, KS-
dc.date.accessioned2017-05-22T09:20:58Z-
dc.date.available2017-05-22T09:20:58Z-
dc.date.issued2015-
dc.identifier.citationThe 51st Annual Meeting of the American Society of Clinical Oncology (ASCO 2015), Chicago, IL., 29 May-2 June 2015. In Journal of Clinical Oncology, 2015, v. 33 n. 15 suppl., abstract no. 6007-
dc.identifier.issn0732-183X-
dc.identifier.urihttp://hdl.handle.net/10722/241006-
dc.descriptionOral Abstract Session - Head and Neck Cancer-
dc.description.abstractBACKGROUND: The relationship between early undetectable plasma EBV DNA after intensity-modulated radiation therapy (IMRT) for NPC and long-term survival remains unclear. Early post-IMRT undetectable plasma EBV DNA is a proposed efficacy endpoint which warrants investigation as a predictor of long-term survival. We prospectively explored the predictive power of post-IMRT 8th week and 6th month undetectable plasma EBV DNA for 3-year survival outcomes in patients with non-metastatic NPC. METHODS: Two hundred and sixty patients with non-metastatic NPC were treated with IMRT +/- concurrent /induction/adjuvant platinum-based chemotherapy. Plasma EBV DNA was taken at diagnosis and then 8 weeks and 6 months after IMRT. Time-dependent Receiver-Operating Characteristics (TD-ROC) were used to obtain Cτ indices. Cox regression models identified interaction between undetectable post-IMRT 8th week and 6th month plasma EBV DNA and outcomes including progression-free survival (PFS), cancer-specific survival (CSS) and overall survival (OS). RESULTS: A strong relationship was shown between post-IMRT 8th week and 6th month undetectable plasma EBV DNA with PFS, CSS and OS (TD-ROC revealing higher Cτ indices for stage IVA–B compared to stage I–III). Cox regression showed that post-IMRT 8th week and 6th month undetectable plasma EBV DNA were prognostic of PFS (p < 0.001 and p < 0.001, respectively), CSS (p = 0.006 and p = 0.004, respectively) and OS (p = 0.039 and p = 0.012, respectively). Baseline plasma EBV DNA was not prognostic of any survival outcome. CONCLUSIONS: Our study showed a strong relationship between post-IMRT 8th week and 6th month undetectable plasma EBV DNA and 3-year survival outcomes. This suggested the use of early plasma EBV DNA as a predictor of survival in this setting.-
dc.languageeng-
dc.publisherAmerican Society of Clinical Oncology. The Journal's web site is located at http://www.jco.org/-
dc.relation.ispartofJournal of Clinical Oncology-
dc.titleSerial early post-intensity-modulated radiation therapy (IMRT) undetectable plasma EBV DNA to predict long-term outcomes in nasopharyngeal cancer (NPC)-
dc.typeConference_Paper-
dc.identifier.emailLee, VHF: vhflee@hku.hk-
dc.identifier.emailKwong, DLW: dlwkwong@hku.hk-
dc.identifier.emailLeung, TW: ltw920@hkucc.hku.hk-
dc.identifier.emailChoi, CW: hcchoi@hku.hk-
dc.identifier.emailNg, SCY: ngchoryi@hku.hk-
dc.identifier.emailLam, KO: lamkaon@hku.hk-
dc.identifier.emailSze, CKH: henrysze@graduate.hku.hk-
dc.identifier.emailTong, CC: tccz01@hku.hk-
dc.identifier.emailHo, PYP: pattyho@hku.hk-
dc.identifier.emailChan, WLW: winglok@hku.hk-
dc.identifier.authorityLee, VHF=rp00264-
dc.identifier.authorityKwong, DLW=rp00414-
dc.identifier.authorityLam, KO=rp01501-
dc.identifier.authoritySze, CKH=rp01697-
dc.identifier.doi10.1200/jco.2015.33.15_suppl.6007-
dc.identifier.hkuros272218-
dc.identifier.volume33-
dc.identifier.issue15 suppl., abstract no. 6007-
dc.publisher.placeUnited States-

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