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Article: Androgen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma

TitleAndrogen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma
Authors
Issue Date2017
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2017, v. 12 n. 2, p. e0171495:1-10 How to Cite?
AbstractOBJECTIVE: Androgen deprivation therapy (ADT) increases fracture risk in men with carcinoma of the prostate, but little is known about the fracture risk for different types of ADT. We studied the fracture risk amongst Chinese patients with carcinoma of the prostate prescribed different ADT regimens. SUBJECTS AND METHODS: This was a single-centered observational study that involved 741 patients with carcinoma of the prostate from January 2001 to December 2011. RESULTS: After a median follow-up of 5 years, 71.7% of the study cohort received ADT and the incidence rate of fracture was 8.1%. Multivariable Cox regression analysis revealed that use of ADT was significantly associated with risk of incident fracture (Hazard Ratio [HR] 3.60; 95% Confidence Interval [95% CI] 1.41-9.23; p = 0.008), together with aged >75 years and type 2 diabetes. Compared with no ADT, all three types of ADT were independently associated with the risk of incident fracture: anti-androgen monotherapy (HR 4.47; 95% CI 1.47-13.7; p = 0.009), bilateral orchiectomy ± anti-androgens (HR 4.01; 95% CI 1.46-11.1; p = 0.007) and luteinizing hormone-releasing hormone agonists ± anti-androgens (HR 3.16; 95% CI 1.18-8.43; p = 0.022). However, there was no significant difference in the relative risks among the three types of ADT. CONCLUSIONS: Fracture risk increases among all types of ADT. Clinicians should take into account the risk-benefit ratio when prescribing ADT, especially in elderly patients with type 2 diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/240946
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395

 

DC FieldValueLanguage
dc.contributor.authorLee, CHP-
dc.contributor.authorHuang, G-
dc.contributor.authorChan, PHM-
dc.contributor.authorHai, SHJJ-
dc.contributor.authorYeung, CY-
dc.contributor.authorFong, HY-
dc.contributor.authorWoo, YC-
dc.contributor.authorHo, KL-
dc.contributor.authorYiu, MK-
dc.contributor.authorLeung, FKL-
dc.contributor.authorLau, TW-
dc.contributor.authorTse, HF-
dc.contributor.authorLam, KSL-
dc.contributor.authorSiu, DCW-
dc.date.accessioned2017-05-22T09:19:56Z-
dc.date.available2017-05-22T09:19:56Z-
dc.date.issued2017-
dc.identifier.citationPLoS One, 2017, v. 12 n. 2, p. e0171495:1-10-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/240946-
dc.description.abstractOBJECTIVE: Androgen deprivation therapy (ADT) increases fracture risk in men with carcinoma of the prostate, but little is known about the fracture risk for different types of ADT. We studied the fracture risk amongst Chinese patients with carcinoma of the prostate prescribed different ADT regimens. SUBJECTS AND METHODS: This was a single-centered observational study that involved 741 patients with carcinoma of the prostate from January 2001 to December 2011. RESULTS: After a median follow-up of 5 years, 71.7% of the study cohort received ADT and the incidence rate of fracture was 8.1%. Multivariable Cox regression analysis revealed that use of ADT was significantly associated with risk of incident fracture (Hazard Ratio [HR] 3.60; 95% Confidence Interval [95% CI] 1.41-9.23; p = 0.008), together with aged >75 years and type 2 diabetes. Compared with no ADT, all three types of ADT were independently associated with the risk of incident fracture: anti-androgen monotherapy (HR 4.47; 95% CI 1.47-13.7; p = 0.009), bilateral orchiectomy ± anti-androgens (HR 4.01; 95% CI 1.46-11.1; p = 0.007) and luteinizing hormone-releasing hormone agonists ± anti-androgens (HR 3.16; 95% CI 1.18-8.43; p = 0.022). However, there was no significant difference in the relative risks among the three types of ADT. CONCLUSIONS: Fracture risk increases among all types of ADT. Clinicians should take into account the risk-benefit ratio when prescribing ADT, especially in elderly patients with type 2 diabetes.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoS One-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAndrogen deprivation therapy and fracture risk in Chinese patients with prostate carcinoma-
dc.typeArticle-
dc.identifier.emailLee, CHP: pchlee@hku.hk-
dc.identifier.emailChan, PHM: phmchan@hku.hk-
dc.identifier.emailHai, SHJJ: haishjj@hku.hk-
dc.identifier.emailYeung, CY: ycy167@hku.hk-
dc.identifier.emailFong, HY: kalofong@hku.hk-
dc.identifier.emailWoo, YC: wooyucho@hku.hk-
dc.identifier.emailHo, KL: hkl218@hkucc.hku.hk-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.identifier.emailLeung, FKL: klleunga@hku.hk-
dc.identifier.emailLau, TW: catcher@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.authorityLee, CHP=rp02043-
dc.identifier.authorityChan, PHM=rp01864-
dc.identifier.authorityHai, SHJJ=rp02047-
dc.identifier.authorityLeung, FKL=rp00297-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authoritySiu, DCW=rp00534-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0171495-
dc.identifier.hkuros272174-
dc.identifier.volume12-
dc.identifier.issue2-
dc.identifier.spagee0171495:1-
dc.identifier.epage10-
dc.publisher.placeUnited States-

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