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Article: A systematic review on the impact of diabetes mellitus on the ocular surface

TitleA systematic review on the impact of diabetes mellitus on the ocular surface
Authors
Issue Date2017
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nutd/index.html
Citation
Nutrition and Diabetes, 2017, v. 7, p. e251:1-10 How to Cite?
AbstractDiabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment. In addition, alterations of immune cells in corneas suggest an inflammatory component in diabetic complications. Furthermore, impaired corneal epithelial wound healing may also imply more widespread disease. The non-invasiveness and improvement in imaging technology facilitates the emergence of new screening tools. Systemic control of diabetes can improve ocular surface health, possibly aided by anti-inflammatory and vasoprotective agents.
Persistent Identifierhttp://hdl.handle.net/10722/240215
ISSN
2015 Impact Factor: 2.773
2015 SCImago Journal Rankings: 1.743
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorShih, KC-
dc.contributor.authorLam, KSL-
dc.contributor.authorTong, L-
dc.date.accessioned2017-04-19T08:21:21Z-
dc.date.available2017-04-19T08:21:21Z-
dc.date.issued2017-
dc.identifier.citationNutrition and Diabetes, 2017, v. 7, p. e251:1-10-
dc.identifier.issn2044-4052-
dc.identifier.urihttp://hdl.handle.net/10722/240215-
dc.description.abstractDiabetes mellitus is associated with extensive morbidity and mortality in any human community. It is well understood that the burden of diabetes is attributed to chronic progressive damage in major end-organs, but it is underappreciated that the most superficial and transparent organ affected by diabetes is the cornea. Different corneal components (epithelium, nerves, immune cells and endothelium) underpin specific systemic complications of diabetes. Just as diabetic retinopathy is a marker of more generalized microvascular disease, corneal nerve changes can predict peripheral and autonomic neuropathy, providing a window of opportunity for early treatment. In addition, alterations of immune cells in corneas suggest an inflammatory component in diabetic complications. Furthermore, impaired corneal epithelial wound healing may also imply more widespread disease. The non-invasiveness and improvement in imaging technology facilitates the emergence of new screening tools. Systemic control of diabetes can improve ocular surface health, possibly aided by anti-inflammatory and vasoprotective agents.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nutd/index.html-
dc.relation.ispartofNutrition and Diabetes-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleA systematic review on the impact of diabetes mellitus on the ocular surface-
dc.typeArticle-
dc.identifier.emailShih, KC: kcshih@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityShih, KC=rp01374-
dc.identifier.authorityLam, KSL=rp00343-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/nutd.2017.4-
dc.identifier.pmcidPMC5380897-
dc.identifier.hkuros271719-
dc.identifier.volume7-
dc.identifier.spagee251:1-
dc.identifier.epage10-
dc.publisher.placeUnited Kingdom-

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