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Article: Protective effects of histamine on Gq-mediated relaxation in regenerated endothelium

TitleProtective effects of histamine on Gq-mediated relaxation in regenerated endothelium
Authors
KeywordsBradykinin
Endothelial cells
Histamine
Issue Date2014
Citation
American Journal of Physiology - Heart and Circulatory Physiology, 2014, v. 306, n. 2 How to Cite?
AbstractIn the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg-1·day-1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration. © 2014 the American Physiological Society.
Persistent Identifierhttp://hdl.handle.net/10722/238098
ISSN
2015 Impact Factor: 3.324
2015 SCImago Journal Rankings: 1.823

 

DC FieldValueLanguage
dc.contributor.authorChan, Calvin K.-
dc.contributor.authorLiao, Song Yan-
dc.contributor.authorZhang, Yue Lin-
dc.contributor.authorXu, Aimin-
dc.contributor.authorTse, Hung Fat-
dc.contributor.authorVanhoutte, Paul M.-
dc.date.accessioned2017-02-03T02:13:01Z-
dc.date.available2017-02-03T02:13:01Z-
dc.date.issued2014-
dc.identifier.citationAmerican Journal of Physiology - Heart and Circulatory Physiology, 2014, v. 306, n. 2-
dc.identifier.issn0363-6135-
dc.identifier.urihttp://hdl.handle.net/10722/238098-
dc.description.abstractIn the porcine coronary artery, regenerated endothelium is dysfunctional as regards the responses to endothelium-dependent agonists. The current study aimed to determine the possible involvement of histamine in such dysfunction. Pigs were treated chronically with pyrilamine (H1 receptor inhibitor, 2 mg·kg-1·day-1) with part of their coronary endothelium and allowed to regenerate for 28 days after balloon denudation. The results showed a reduction in relaxation to bradykinin (Gq protein dependent) only in the pyrilamine-treated group (area under the curve, 269.7 ± 13.4 vs. 142.0 ± 31.0, native endothelium vs. regenerated endothelium) but not in the control group (253.0 ± 22.1 vs. 231.9 ± 29.5, native endothelium vs. regenerated endothelium). The differences in the relaxation to serotonin (Gi protein dependent) between native and regenerated endothelium were not affected by the pyrilamine treatment (control group, 106.3 ± 17.0 vs. 55.61 ± 12.7; and pyrilamine group, 106.0 ± 8.20 vs. 49.30 ± 6.31, native endothelium vs. regenerated endothelium). These findings indicate that during regeneration of the endothelium, the activation of H1 receptors by endogenous histamine may be required to maintain the endothelium-dependent Gq protein-mediated relaxation to bradykinin, suggesting a beneficial role of the monoamine in the process of endothelial regeneration. © 2014 the American Physiological Society.-
dc.languageeng-
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiology-
dc.subjectBradykinin-
dc.subjectEndothelial cells-
dc.subjectHistamine-
dc.titleProtective effects of histamine on Gq-mediated relaxation in regenerated endothelium-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1152/ajpheart.00733.2013-
dc.identifier.pmid24213613-
dc.identifier.scopuseid_2-s2.0-84892609853-
dc.identifier.volume306-
dc.identifier.issue2-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1522-1539-

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