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Conference Paper: Customized topography with tailored porosity control of composite 3D scaffold for enhanced bone tissue engineering

TitleCustomized topography with tailored porosity control of composite 3D scaffold for enhanced bone tissue engineering
Authors
Issue Date2016
PublisherOral Health and Dental Management. The Journal's web site is located at http://oralhealth.ro/
Citation
The 11th Asia Pacific Congress on Dental and Oral Health, Bangkok, Thailand, 25-27 July 2016. In Oral Health and Dental Management, 2016, v. 15 n. 4 suppl., p. 30 How to Cite?
AbstractBioceramic biomaterials provide excellent support for bone tissue engineering, yet there are many shortcomings in physicochemical properties to be improved. Surface topographical features ranging from nano to macro are of great importance in determining the particular cellular responses toward the scaffold. There have been many attempts in the literature to tailor the porosity in order to modify the surface topography. It is known that pore dimension, geometry and overall porosity and interconnectivity have significant impact on cellular attachment, migration and communication. However, the control of porosity parameters in 3D scaffold structure is a challenging task. Different porogens to better customize the porosity have been studied but the challenges are difficult control over pore size and the need to remove porogens to avoid cytotoxic effects. Here, we introduce a novel technique by using non-toxic nonionic surfactant (Tween) as porogens to aid in customizing surface topography by modifying porosity features of composite collagen- HA scaffolds during lyophilization process. Four different ratios of Tween (0, 10, 20, 30 wt%) and two ratios of collagen-HA (85/15 and 92/8 wt%) along with a controlled quenching rate allowed production of a range of porosities (> 90%), pore sizes (≤ 500 nm and 100-300 μm) with high interconnectivity. It is assumed that a range of pore size and geometry will provide a suitable topographical feature that may better support vascularization and cells communication. This will be of great advantages over conventional scaffolds in supporting cellular interactions and improving cellular behaviors for enhanced bone tissue engineering.
DescriptionOpen Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/237316
ISSN
2015 SCImago Journal Rankings: 0.206

 

DC FieldValueLanguage
dc.contributor.authorEbrahimi, MA-
dc.contributor.authorMonmaturapoj, N-
dc.contributor.authorBotelho, MG-
dc.date.accessioned2016-12-30T01:41:20Z-
dc.date.available2016-12-30T01:41:20Z-
dc.date.issued2016-
dc.identifier.citationThe 11th Asia Pacific Congress on Dental and Oral Health, Bangkok, Thailand, 25-27 July 2016. In Oral Health and Dental Management, 2016, v. 15 n. 4 suppl., p. 30-
dc.identifier.issn2247-2452-
dc.identifier.urihttp://hdl.handle.net/10722/237316-
dc.descriptionOpen Access Journal-
dc.description.abstractBioceramic biomaterials provide excellent support for bone tissue engineering, yet there are many shortcomings in physicochemical properties to be improved. Surface topographical features ranging from nano to macro are of great importance in determining the particular cellular responses toward the scaffold. There have been many attempts in the literature to tailor the porosity in order to modify the surface topography. It is known that pore dimension, geometry and overall porosity and interconnectivity have significant impact on cellular attachment, migration and communication. However, the control of porosity parameters in 3D scaffold structure is a challenging task. Different porogens to better customize the porosity have been studied but the challenges are difficult control over pore size and the need to remove porogens to avoid cytotoxic effects. Here, we introduce a novel technique by using non-toxic nonionic surfactant (Tween) as porogens to aid in customizing surface topography by modifying porosity features of composite collagen- HA scaffolds during lyophilization process. Four different ratios of Tween (0, 10, 20, 30 wt%) and two ratios of collagen-HA (85/15 and 92/8 wt%) along with a controlled quenching rate allowed production of a range of porosities (> 90%), pore sizes (≤ 500 nm and 100-300 μm) with high interconnectivity. It is assumed that a range of pore size and geometry will provide a suitable topographical feature that may better support vascularization and cells communication. This will be of great advantages over conventional scaffolds in supporting cellular interactions and improving cellular behaviors for enhanced bone tissue engineering.-
dc.languageeng-
dc.publisherOral Health and Dental Management. The Journal's web site is located at http://oralhealth.ro/-
dc.relation.ispartofOral Health and Dental Management-
dc.titleCustomized topography with tailored porosity control of composite 3D scaffold for enhanced bone tissue engineering-
dc.typeConference_Paper-
dc.identifier.emailBotelho, MG: botelho@hkucc.hku.hk-
dc.identifier.authorityBotelho, MG=rp00033-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.4172/2247-2452.C1.033-
dc.identifier.hkuros270928-
dc.identifier.volume15-
dc.identifier.issue4 suppl.-
dc.identifier.spage30-
dc.identifier.epage30-
dc.publisher.placeRomania-

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