File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)

Article: Liposome disruption detected by surface plasma resonance at lower concentrations of a peptide antibiotic

TitleLiposome disruption detected by surface plasma resonance at lower concentrations of a peptide antibiotic
Authors
Issue Date2000
Citation
Langmuir, 2000, v. 16, n. 26, p. 9959-9962 How to Cite?
AbstractDependence of the concentration of peptide antibiotics on the lysis of liposomes of different compositions is presented in this study. Here, we clearly demonstrate that cecropin B and its analogues can lyse anionic liposomes immobilized on a biosensor chip. Surface plasmon resonance measurements showed that, for two peptides, lysis was only induced at low peptide concentrations and, at higher concentrations, the peptides bound to the liposomes without lysing them. The concentration-dependent mechanism of peptide-lipid interactions revealed here is relevant to the action of cationic peptides on the anionic membranes of bacteria and neoplastic cells. Use of the technique described here will provide a new direction to assess the action and efficacy of antibacterial peptides, antibiotics, and anticancer agents.
Persistent Identifierhttp://hdl.handle.net/10722/236716
ISSN
2015 Impact Factor: 3.993
2015 SCImago Journal Rankings: 1.750

 

DC FieldValueLanguage
dc.contributor.authorChen, H. M.-
dc.contributor.authorWang, W.-
dc.contributor.authorSmith, D. K.-
dc.date.accessioned2016-12-02T03:07:28Z-
dc.date.available2016-12-02T03:07:28Z-
dc.date.issued2000-
dc.identifier.citationLangmuir, 2000, v. 16, n. 26, p. 9959-9962-
dc.identifier.issn0743-7463-
dc.identifier.urihttp://hdl.handle.net/10722/236716-
dc.description.abstractDependence of the concentration of peptide antibiotics on the lysis of liposomes of different compositions is presented in this study. Here, we clearly demonstrate that cecropin B and its analogues can lyse anionic liposomes immobilized on a biosensor chip. Surface plasmon resonance measurements showed that, for two peptides, lysis was only induced at low peptide concentrations and, at higher concentrations, the peptides bound to the liposomes without lysing them. The concentration-dependent mechanism of peptide-lipid interactions revealed here is relevant to the action of cationic peptides on the anionic membranes of bacteria and neoplastic cells. Use of the technique described here will provide a new direction to assess the action and efficacy of antibacterial peptides, antibiotics, and anticancer agents.-
dc.languageeng-
dc.relation.ispartofLangmuir-
dc.titleLiposome disruption detected by surface plasma resonance at lower concentrations of a peptide antibiotic-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1021/la001100l-
dc.identifier.scopuseid_2-s2.0-0034498569-
dc.identifier.volume16-
dc.identifier.issue26-
dc.identifier.spage9959-
dc.identifier.epage9962-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats