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Article: Vitamin B12 in obese adolescents with clinical features of insulin resistance

TitleVitamin B12 in obese adolescents with clinical features of insulin resistance
Authors
KeywordsObesity
Vitamin B12 deficiency
Adolescents
Cobalamin
Insulin resistance
Issue Date2014
Citation
Nutrients, 2014, v. 6, n. 12, p. 5611-5618 How to Cite?
Abstract© 2014 by the authors; licensee MDPI, Basel, Switzerland.Emerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin resistance. Serum B12 was measured using chemiluminescence immunoassay in 103 (43 male, 60 female) obese (mean body mass index (BMI) z-score ± SD (2.36 ± 0.29)), adolescents aged 10 to 17 years, median (range) insulin sensitivity index of 1.27 (0.27 to 3.38) and 13.6% had pre-diabetes. Low B12 (<148 pmol/L) was identified in eight (7.8%) and borderline status (148 to 221 pmol/L) in an additional 25 (24.3%) adolescents. Adolescents with borderline B12 concentrations had higher BMI z-scores compared to those with normal concentrations (2.50 ± 0.22 vs. 2.32 ± 0.30, p = 0.008) or those with low B12 concentration (2.50 ± 0.22 vs. 2.27 ± 0.226, p = 0.041). In conclusion, nearly a third of obese adolescents with clinical insulin resistance had a low or borderline serum B12 status. Therefore, further investigations are warranted to explore the cause and the impact of low B12 status in obese pediatric populations.
Persistent Identifierhttp://hdl.handle.net/10722/236687

 

DC FieldValueLanguage
dc.contributor.authorHo, Mandy-
dc.contributor.authorHalim, Jocelyn H.-
dc.contributor.authorGow, Megan L.-
dc.contributor.authorEl-Haddad, Nouhad-
dc.contributor.authorBaur, Louise A.-
dc.contributor.authorCowell, Chris T.-
dc.contributor.authorGarnett, Sarah P.-
dc.contributor.authorMarzulli, Teresa-
dc.date.accessioned2016-12-01T09:08:36Z-
dc.date.available2016-12-01T09:08:36Z-
dc.date.issued2014-
dc.identifier.citationNutrients, 2014, v. 6, n. 12, p. 5611-5618-
dc.identifier.urihttp://hdl.handle.net/10722/236687-
dc.description.abstract© 2014 by the authors; licensee MDPI, Basel, Switzerland.Emerging evidence indicates an association between obesity, metformin use and reduced vitamin B12 status, which can have serious hematologic, neurologic and psychiatric consequences. This study aimed to examine B12 status in obese adolescents with pre-diabetes and/or clinical features of insulin resistance. Serum B12 was measured using chemiluminescence immunoassay in 103 (43 male, 60 female) obese (mean body mass index (BMI) z-score ± SD (2.36 ± 0.29)), adolescents aged 10 to 17 years, median (range) insulin sensitivity index of 1.27 (0.27 to 3.38) and 13.6% had pre-diabetes. Low B12 (<148 pmol/L) was identified in eight (7.8%) and borderline status (148 to 221 pmol/L) in an additional 25 (24.3%) adolescents. Adolescents with borderline B12 concentrations had higher BMI z-scores compared to those with normal concentrations (2.50 ± 0.22 vs. 2.32 ± 0.30, p = 0.008) or those with low B12 concentration (2.50 ± 0.22 vs. 2.27 ± 0.226, p = 0.041). In conclusion, nearly a third of obese adolescents with clinical insulin resistance had a low or borderline serum B12 status. Therefore, further investigations are warranted to explore the cause and the impact of low B12 status in obese pediatric populations.-
dc.languageeng-
dc.relation.ispartofNutrients-
dc.subjectObesity-
dc.subjectVitamin B12 deficiency-
dc.subjectAdolescents-
dc.subjectCobalamin-
dc.subjectInsulin resistance-
dc.titleVitamin B12 in obese adolescents with clinical features of insulin resistance-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.3390/nu6125611-
dc.identifier.pmid25486369-
dc.identifier.scopuseid_2-s2.0-84915756474-
dc.identifier.volume6-
dc.identifier.issue12-
dc.identifier.spage5611-
dc.identifier.epage5618-
dc.identifier.eissn2072-6643-

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