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Article: Antioxidant activity of gallic acid from rose flowers in senescence accelerated mice

TitleAntioxidant activity of gallic acid from rose flowers in senescence accelerated mice
Authors
KeywordsAnimal models
CAT
GPx
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie
Citation
Life Sciences, 2005, v. 77 n. 2, p. 230-240 How to Cite?
AbstractThe activities of the antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx) in the blood and liver of the aging model induced by injection of different doses of D-gal into normal mice, and in senescence accelerated mice (SAM) of different ages, were determined. The results showed that the enzyme activities in the D-gal treated mice did not alter appreciably but the enzyme activities in blood of the SAM declined significantly with the increase in age, especially in the 9-month-old SAM. When gallic acid purified from rose flowers was used to treat the 9-month-old male SAM, it not only reinstated the activities of CAT and GPx but also significantly reduced the amount of malondialdehyde (MDA) in the liver, brain and kidney. The results demonstrated that 9-month-old male SAM represent an appropriate animal model to evaluate the antioxidant activities of natural products.
Persistent Identifierhttp://hdl.handle.net/10722/236315
ISSN
2017 Impact Factor: 3.234
2015 SCImago Journal Rankings: 1.056

 

DC FieldValueLanguage
dc.contributor.authorLi, L-
dc.contributor.authorNg, TB-
dc.contributor.authorGao, W-
dc.contributor.authorLi, W-
dc.contributor.authorFu, M-
dc.contributor.authorNiu, SM-
dc.contributor.authorZhao, L-
dc.contributor.authorChen, RR-
dc.contributor.authorLiu, F-
dc.date.accessioned2016-11-16T02:46:48Z-
dc.date.available2016-11-16T02:46:48Z-
dc.date.issued2005-
dc.identifier.citationLife Sciences, 2005, v. 77 n. 2, p. 230-240-
dc.identifier.issn0024-3205-
dc.identifier.urihttp://hdl.handle.net/10722/236315-
dc.description.abstractThe activities of the antioxidant enzymes catalase (CAT) and glutathione peroxidase (GPx) in the blood and liver of the aging model induced by injection of different doses of D-gal into normal mice, and in senescence accelerated mice (SAM) of different ages, were determined. The results showed that the enzyme activities in the D-gal treated mice did not alter appreciably but the enzyme activities in blood of the SAM declined significantly with the increase in age, especially in the 9-month-old SAM. When gallic acid purified from rose flowers was used to treat the 9-month-old male SAM, it not only reinstated the activities of CAT and GPx but also significantly reduced the amount of malondialdehyde (MDA) in the liver, brain and kidney. The results demonstrated that 9-month-old male SAM represent an appropriate animal model to evaluate the antioxidant activities of natural products.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/lifescie-
dc.relation.ispartofLife Sciences-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectAnimal models-
dc.subjectCAT-
dc.subjectGPx-
dc.titleAntioxidant activity of gallic acid from rose flowers in senescence accelerated mice-
dc.typeArticle-
dc.identifier.emailGao, W: gaoweiwayne@gmail.com-
dc.identifier.authorityGao, W=rp02222-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lfs.2004.12.024-
dc.identifier.pmid15862607-
dc.identifier.scopuseid_2-s2.0-18044374253-
dc.identifier.volume77-
dc.identifier.issue2-
dc.identifier.spage230-
dc.identifier.epage240-
dc.publisher.placeUnited States-

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