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Article: Effect of Systemic Tetracycline on the Degradation of Tetracycline-Impregnated Bilayered Collagen Membranes: An Animal Study

TitleEffect of Systemic Tetracycline on the Degradation of Tetracycline-Impregnated Bilayered Collagen Membranes: An Animal Study
Authors
KeywordsMembrane
Tetracycline
In vivo
Collagen
Bone augmentation
Issue Date2010
Citation
Clinical Implant Dentistry and Related Research, 2010, v. 12, n. 4, p. 331-337 How to Cite?
AbstractBackground: Premature collagen membrane degradation may compromise the outcome of osseous regenerative procedures. Tetracyclines (TTCs) inhibit the catalytic activities of human metalloproteinases. Preprocedural immersion of collagen membranes in TTC and systemic administration of TTC may be possible alternatives to reduce the biodegradation of native collagen membranes.Aim: To evaluate the in vivo degradation of collagen membranes treated by combined TTC immersion and systemic administration. Materials and Methods: Seventy-eight bilayered porcine collagen membrane disks were divided into three groups and were immersed in 0, 50, or 100mg/mL TTC solution. Three disks, one of each of the three groups, were implanted on the calvaria of each of 26 Wistar rats. Thirteen (study group) were administered with systemic TTC (10mg/kg), while the remaining 13 received saline injections (control group). Calvarial tissues were retrieved after 3 weeks, and histological sections were analyzed by image analysis software. Results: Percentage of remaining collagen area within nonimpregnated membranes was 52.26±20.67% in the study group, and 32.74±13.81% in the control group. Immersion of membranes in 100mg/mL TTC increased the amount of residual collagen to 63.46±18.19% and 42.82±12.99% (study and control groups, respectively). Immersion in 50mg/mL TTC yielded maximal residual collagen values: 80.75±14.86% and 59.15±8.01% (study and control groups, respectively). Differences between the TTC concentrations, and between the control and the study groups were statistically significant.Conclusions: Immersion of collagen membranes in TTC solution prior to their implantation and systemic administration of TTC significantly decreased the membranes' degradation. © 2009, Copyright the Authors. Journal Compilation © 2010, Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/236163
ISSN
2015 Impact Factor: 4.152
2015 SCImago Journal Rankings: 1.165

 

DC FieldValueLanguage
dc.contributor.authorMoses, Ofer-
dc.contributor.authorFrenkel, Tami-
dc.contributor.authorTal, Haim-
dc.contributor.authorWeinreb, Miron-
dc.contributor.authorBornstein, Michael M.-
dc.contributor.authorNemcovsky, Carlos E.-
dc.date.accessioned2016-11-11T07:43:06Z-
dc.date.available2016-11-11T07:43:06Z-
dc.date.issued2010-
dc.identifier.citationClinical Implant Dentistry and Related Research, 2010, v. 12, n. 4, p. 331-337-
dc.identifier.issn1523-0899-
dc.identifier.urihttp://hdl.handle.net/10722/236163-
dc.description.abstractBackground: Premature collagen membrane degradation may compromise the outcome of osseous regenerative procedures. Tetracyclines (TTCs) inhibit the catalytic activities of human metalloproteinases. Preprocedural immersion of collagen membranes in TTC and systemic administration of TTC may be possible alternatives to reduce the biodegradation of native collagen membranes.Aim: To evaluate the in vivo degradation of collagen membranes treated by combined TTC immersion and systemic administration. Materials and Methods: Seventy-eight bilayered porcine collagen membrane disks were divided into three groups and were immersed in 0, 50, or 100mg/mL TTC solution. Three disks, one of each of the three groups, were implanted on the calvaria of each of 26 Wistar rats. Thirteen (study group) were administered with systemic TTC (10mg/kg), while the remaining 13 received saline injections (control group). Calvarial tissues were retrieved after 3 weeks, and histological sections were analyzed by image analysis software. Results: Percentage of remaining collagen area within nonimpregnated membranes was 52.26±20.67% in the study group, and 32.74±13.81% in the control group. Immersion of membranes in 100mg/mL TTC increased the amount of residual collagen to 63.46±18.19% and 42.82±12.99% (study and control groups, respectively). Immersion in 50mg/mL TTC yielded maximal residual collagen values: 80.75±14.86% and 59.15±8.01% (study and control groups, respectively). Differences between the TTC concentrations, and between the control and the study groups were statistically significant.Conclusions: Immersion of collagen membranes in TTC solution prior to their implantation and systemic administration of TTC significantly decreased the membranes' degradation. © 2009, Copyright the Authors. Journal Compilation © 2010, Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofClinical Implant Dentistry and Related Research-
dc.subjectMembrane-
dc.subjectTetracycline-
dc.subjectIn vivo-
dc.subjectCollagen-
dc.subjectBone augmentation-
dc.titleEffect of Systemic Tetracycline on the Degradation of Tetracycline-Impregnated Bilayered Collagen Membranes: An Animal Study-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1708-8208.2009.00173.x-
dc.identifier.pmid19438957-
dc.identifier.scopuseid_2-s2.0-78349248245-
dc.identifier.volume12-
dc.identifier.issue4-
dc.identifier.spage331-
dc.identifier.epage337-
dc.identifier.eissn1708-8208-

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