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Article: Effect of two different bioabsorbable collagen membranes on guided bone regeneration: A comparative histomorphometric study in the dog mandible

TitleEffect of two different bioabsorbable collagen membranes on guided bone regeneration: A comparative histomorphometric study in the dog mandible
Authors
KeywordsReactions
Bone regeneration
Tissue
Collagen
Cross-linking
Membranes
Issue Date2007
Citation
Journal of Periodontology, 2007, v. 78, n. 10, p. 1943-1953 How to Cite?
AbstractBackground: This study compared bone regeneration following guided bone regeneration with two bioabsorbable collagen membranes in saddle-type bone defects in dog mandibles. Methods: Three standardized defects were created, filled with bone chips and deproteinized bovine bone mineral (DBBM), and covered by three different methods: control = no membrane; test 1 = collagen membrane; and test 2 = cross-linked collagen membrane (CCM). Each side of the mandible was allocated to one of two healing periods (8 or 16 weeks). The histomorphometric analysis assessed the percentage of bone, soft tissue, and DBBM in the regenerate; the absolute area in square millimeters of the bone regenerate; and the distance in millimeters from the bottom of the defect to the highest point of the regenerate. Results: In the 8-week healing group, two dehiscences occurred with CCM. After 8 weeks, all treatment modalities showed no significant differences in the percentage of bone regenerate. After 16 weeks, the percentage of bone had increased for all treatment modalities without significant differences. For all groups, the defect fill height increased between weeks 8 and 16. The CCM group showed a statistically significant (P= 0.0202) increase over time and the highest value of all treatment modalities after 16 weeks of healing. Conclusions: The CCM showed a limited beneficial effect on bone regeneration in membrane-protected defects in dog mandibles when healing was uneventful. The observed premature membrane exposures resulted in severely compromised amounts of bone regenerate. This increased complication rate with CCM requires a more detailed preclinical and clinical examination before any clinical recommendations can be made.
Persistent Identifierhttp://hdl.handle.net/10722/236121
ISSN
2017 Impact Factor: 3.392
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBornstein, Michael M.-
dc.contributor.authorBosshardt, Dieter-
dc.contributor.authorBuser, Daniel-
dc.date.accessioned2016-11-11T07:43:00Z-
dc.date.available2016-11-11T07:43:00Z-
dc.date.issued2007-
dc.identifier.citationJournal of Periodontology, 2007, v. 78, n. 10, p. 1943-1953-
dc.identifier.issn0022-3492-
dc.identifier.urihttp://hdl.handle.net/10722/236121-
dc.description.abstractBackground: This study compared bone regeneration following guided bone regeneration with two bioabsorbable collagen membranes in saddle-type bone defects in dog mandibles. Methods: Three standardized defects were created, filled with bone chips and deproteinized bovine bone mineral (DBBM), and covered by three different methods: control = no membrane; test 1 = collagen membrane; and test 2 = cross-linked collagen membrane (CCM). Each side of the mandible was allocated to one of two healing periods (8 or 16 weeks). The histomorphometric analysis assessed the percentage of bone, soft tissue, and DBBM in the regenerate; the absolute area in square millimeters of the bone regenerate; and the distance in millimeters from the bottom of the defect to the highest point of the regenerate. Results: In the 8-week healing group, two dehiscences occurred with CCM. After 8 weeks, all treatment modalities showed no significant differences in the percentage of bone regenerate. After 16 weeks, the percentage of bone had increased for all treatment modalities without significant differences. For all groups, the defect fill height increased between weeks 8 and 16. The CCM group showed a statistically significant (P= 0.0202) increase over time and the highest value of all treatment modalities after 16 weeks of healing. Conclusions: The CCM showed a limited beneficial effect on bone regeneration in membrane-protected defects in dog mandibles when healing was uneventful. The observed premature membrane exposures resulted in severely compromised amounts of bone regenerate. This increased complication rate with CCM requires a more detailed preclinical and clinical examination before any clinical recommendations can be made.-
dc.languageeng-
dc.relation.ispartofJournal of Periodontology-
dc.subjectReactions-
dc.subjectBone regeneration-
dc.subjectTissue-
dc.subjectCollagen-
dc.subjectCross-linking-
dc.subjectMembranes-
dc.titleEffect of two different bioabsorbable collagen membranes on guided bone regeneration: A comparative histomorphometric study in the dog mandible-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1902/jop.2007.070102-
dc.identifier.pmid18062116-
dc.identifier.scopuseid_2-s2.0-35648968116-
dc.identifier.volume78-
dc.identifier.issue10-
dc.identifier.spage1943-
dc.identifier.epage1953-
dc.identifier.isiWOS:000250277200012-

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