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Book Chapter: Genomics Study of Gastric Cancer and Its Molecular Subtypes

TitleGenomics Study of Gastric Cancer and Its Molecular Subtypes
Authors
Issue Date2016
PublisherSpringer International Publishing
Citation
Genomics Study of Gastric Cancer and Its Molecular Subtypes. In Jansen, M & Wright, NA (Eds.), Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract, p. 419-439. Cham: Springer International Publishing, 2016 How to Cite?
AbstractGastric cancer is a heterogeneous disease encompassing diverse morphological (intestinal versus diffuse) and molecular subtypes (MSI, EBV, TP53 mutation). Recent advances in genomic technology have led to an improved understanding of the driver gene mutational profile, gene expression, and epigenetic alterations that underlie each of the subgroups, with therapeutic implications in some of these alterations. There have been attempts to classify gastric cancers based on these genomic features, with an aim to improve prognostication and predict responsiveness to specific drug therapy. The eventual aims of these genomic studies are to develop deep biological insights into the carcinogenic pathway in each of these subtypes. Future large-scale drug screening strategies may then be able to link these genomic features to drug responsiveness, eventually leading to genome-guided personalized medicine with improved cure rates.
Persistent Identifierhttp://hdl.handle.net/10722/235610
ISBN

 

DC FieldValueLanguage
dc.contributor.authorYuen, ST-
dc.contributor.authorLeung, SY-
dc.date.accessioned2016-10-14T13:54:20Z-
dc.date.available2016-10-14T13:54:20Z-
dc.date.issued2016-
dc.identifier.citationGenomics Study of Gastric Cancer and Its Molecular Subtypes. In Jansen, M & Wright, NA (Eds.), Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract, p. 419-439. Cham: Springer International Publishing, 2016-
dc.identifier.isbn9783319413860-
dc.identifier.urihttp://hdl.handle.net/10722/235610-
dc.description.abstractGastric cancer is a heterogeneous disease encompassing diverse morphological (intestinal versus diffuse) and molecular subtypes (MSI, EBV, TP53 mutation). Recent advances in genomic technology have led to an improved understanding of the driver gene mutational profile, gene expression, and epigenetic alterations that underlie each of the subgroups, with therapeutic implications in some of these alterations. There have been attempts to classify gastric cancers based on these genomic features, with an aim to improve prognostication and predict responsiveness to specific drug therapy. The eventual aims of these genomic studies are to develop deep biological insights into the carcinogenic pathway in each of these subtypes. Future large-scale drug screening strategies may then be able to link these genomic features to drug responsiveness, eventually leading to genome-guided personalized medicine with improved cure rates.-
dc.languageeng-
dc.publisherSpringer International Publishing-
dc.relation.ispartofStem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract-
dc.titleGenomics Study of Gastric Cancer and Its Molecular Subtypes-
dc.typeBook_Chapter-
dc.identifier.emailYuen, ST: styuen@hkucc.hku.hk-
dc.identifier.emailLeung, SY: suetyi@hku.hk-
dc.identifier.authorityLeung, SY=rp00359-
dc.identifier.doi10.1007/978-3-319-41388-4_21-
dc.identifier.pmid27573784-
dc.identifier.hkuros269989-
dc.identifier.volume908-
dc.identifier.spage419-
dc.identifier.epage439-
dc.publisher.placeCham-

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