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Conference Paper: Prospective study on the performance of the prostate-specific antigen isoform P2PSA and its derivative prostate health index in prediction of prostate cancer in local Chinese men with total prostate-specific antigen levels of 4-10 ng/mL

TitleProspective study on the performance of the prostate-specific antigen isoform P2PSA and its derivative prostate health index in prediction of prostate cancer in local Chinese men with total prostate-specific antigen levels of 4-10 ng/mL
Authors
Issue Date2016
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU
Citation
The 14th Urological Association of Asia Congress (UAA 2016) in conjunction with UROFAIR 2016, Urology Residents' Course 2016, and the 30th Anniversary of the Singapore Urological Association, Singapore, 20-24 July 2016. In International Journal of Urology, 2016, v. 23 suppl. S1, p. 62, abstract no. C-OPRO-1872 How to Cite?
AbstractOBJECTIVES To evaluate the accuracy of the prostate-specific antigen isoform P2PSA and its derivatives including Prostate Health Index (PHI) in determining the presence of prostate cancer in prostate biopsies with serum total prostate-specific antigen (tPSA) at 4–10 ng/mL. METHODS This was a prospective cohort study involving two urology centers. Patients with tPSA at 4–10 ng/mL with a negative digital rectal examination who consented to prostate biopsy to detect underlying prostate cancer were recruited from March 2013 to March 2016. Their serum tPSA and P2PSA were checked before the biopsy and evaluated with respect to their prostate biopsy results. RESULTS Two hundred and forty-seven patients were recruited with cancer detected in 43 (17.4%) patients. %P2PSA and PHI were significantly higher in patients with cancer (P < 0.0001) whilst %fPSA and tPSA were similar between the two groups. ROC analysis showed the AUC for tPSA, %fPSA, %PSPSA and PHI to be 0.50, 0.58, 0.77 and 0.76 respectively. %P2PSA and PHI were the best predictor of underlying prostate cancer and were significantly better than tPSA (P < 0.0001 and 0.0005 respectively). At a sensitivity of 90%, PHI has the highest specificity (43.1%) amongst all the markers (tPSA: 7.4%, % fPSA: 27.0%, %P2PSA: 37.7%). When compared with tPSA, the use of the PHI would avoid 73(39%) of patients from unnecessary biopsies. CONCLUSIONS PHI is a superior marker to tPSA in detection of prostate cancer in our cohort of local Chinese men. Its use in addition to tPSA can improve its accuracy and aids in patient counseling regarding whether to proceed with prostate biopsies.
DescriptionConference Theme: Urological Advancement in Asia
Abstract and Poster Presentation
This free journal suppl. entitled: Special Issue: 14th Urological Association of Asia Congress 2016 Singapore
Persistent Identifierhttp://hdl.handle.net/10722/235196
ISSN
2015 Impact Factor: 1.878
2015 SCImago Journal Rankings: 0.841

 

DC FieldValueLanguage
dc.contributor.authorTsang, CF-
dc.contributor.authorYiu, MK-
dc.contributor.authorCheung, FK-
dc.contributor.authorChiu, Y-
dc.contributor.authorHo, SHB-
dc.contributor.authorNg, ATL-
dc.contributor.authorWong, JKW-
dc.contributor.authorWong, CKW-
dc.contributor.authorPoon, VY-
dc.contributor.authorMa, WK-
dc.contributor.authorTsu, HLJ-
dc.date.accessioned2016-10-14T13:51:51Z-
dc.date.available2016-10-14T13:51:51Z-
dc.date.issued2016-
dc.identifier.citationThe 14th Urological Association of Asia Congress (UAA 2016) in conjunction with UROFAIR 2016, Urology Residents' Course 2016, and the 30th Anniversary of the Singapore Urological Association, Singapore, 20-24 July 2016. In International Journal of Urology, 2016, v. 23 suppl. S1, p. 62, abstract no. C-OPRO-1872-
dc.identifier.issn0919-8172-
dc.identifier.urihttp://hdl.handle.net/10722/235196-
dc.descriptionConference Theme: Urological Advancement in Asia-
dc.descriptionAbstract and Poster Presentation-
dc.descriptionThis free journal suppl. entitled: Special Issue: 14th Urological Association of Asia Congress 2016 Singapore-
dc.description.abstractOBJECTIVES To evaluate the accuracy of the prostate-specific antigen isoform P2PSA and its derivatives including Prostate Health Index (PHI) in determining the presence of prostate cancer in prostate biopsies with serum total prostate-specific antigen (tPSA) at 4–10 ng/mL. METHODS This was a prospective cohort study involving two urology centers. Patients with tPSA at 4–10 ng/mL with a negative digital rectal examination who consented to prostate biopsy to detect underlying prostate cancer were recruited from March 2013 to March 2016. Their serum tPSA and P2PSA were checked before the biopsy and evaluated with respect to their prostate biopsy results. RESULTS Two hundred and forty-seven patients were recruited with cancer detected in 43 (17.4%) patients. %P2PSA and PHI were significantly higher in patients with cancer (P < 0.0001) whilst %fPSA and tPSA were similar between the two groups. ROC analysis showed the AUC for tPSA, %fPSA, %PSPSA and PHI to be 0.50, 0.58, 0.77 and 0.76 respectively. %P2PSA and PHI were the best predictor of underlying prostate cancer and were significantly better than tPSA (P < 0.0001 and 0.0005 respectively). At a sensitivity of 90%, PHI has the highest specificity (43.1%) amongst all the markers (tPSA: 7.4%, % fPSA: 27.0%, %P2PSA: 37.7%). When compared with tPSA, the use of the PHI would avoid 73(39%) of patients from unnecessary biopsies. CONCLUSIONS PHI is a superior marker to tPSA in detection of prostate cancer in our cohort of local Chinese men. Its use in addition to tPSA can improve its accuracy and aids in patient counseling regarding whether to proceed with prostate biopsies.-
dc.languageeng-
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU-
dc.relation.ispartofInternational Journal of Urology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleProspective study on the performance of the prostate-specific antigen isoform P2PSA and its derivative prostate health index in prediction of prostate cancer in local Chinese men with total prostate-specific antigen levels of 4-10 ng/mL-
dc.typeConference_Paper-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.identifier.emailWong, CKW: kwwongab@hku.hk-
dc.identifier.emailMa, WK: mwk054@hku.hk-
dc.identifier.emailTsu, HLJ: jamestsu@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/iju.13149-
dc.identifier.hkuros270378-
dc.identifier.volume23-
dc.identifier.issuesuppl. S1-
dc.identifier.spage62, abstract no. C-OPRO-1872-
dc.identifier.epage62, abstract no. C-OPRO-1872-
dc.publisher.placeAustralia-

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