File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Conference Paper: Will intermediate or high risks prostate cancer patients be mistakenly assigned into active surveillance programme? A retrospective review in Hong Kong

TitleWill intermediate or high risks prostate cancer patients be mistakenly assigned into active surveillance programme? A retrospective review in Hong Kong
Authors
Issue Date2016
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU
Citation
The 14th Urological Association of Asia Congress (UAA 2016) in conjunction with UROFAIR 2016, Urology Residents' Course 2016, and the 30th Anniversary of the Singapore Urological Association, Singapore, 20-24 July 2016. In International Journal of Urology, 2016, v. 23 suppl. S1, p. 68, abstract no. C-OPRO-4492 How to Cite?
AbstractOBJECTIVES Review the pathology of radical prostatectomy (RP) and investigate patients who were eligible for active surveillance (AS) on preoperative investigations and assess any pathological and radiological upstage of prostate cancer. METHODS A total of 158 patient underwent radical prostatectomy (RP) from September, 2011 to October, 2015 in Queen Mary Hospital were retrospectively reviewed. Baseline characteristics, transrectal ultrasound (TRUS) biopsy details, magnetic resonance imaging (MRI) and RP pathology were analysed. Univariate and multivariate analyses were used to identify any significant predictors of upstaged disease. RESULTS There were 48 patients fulfilled the Memorial Sloan Kettering Cancer Centre (MSKCC) criteria for AS. The accuracy of TRUS biopsy in predicting Gleason score and MRI in predicting extra-capsular disease were 52% and 95% respectively. The positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity and accuracy of TRUS biopsy, MRI and combination of TRUS biopsy and MRI for laterality of disease are 16%, 100%, 100%, 5%, 19%; 23%,92%, 88%, 34%, 44% and 21%, 93%, 88%, 35%, 44% respectively. 46% of patients have upstaged disease with 15% were high risk prostate cancer. Age (HR 1.12, P = 0.025) and PSA density (HR 2.12, P = 0.017) were independent predictors on both univariate and multivariate analyses. CONCLUSION Both TRUS biopsy and MRI have a low positive predictive in low risks prostate cancer and significant upstaging in final pathology is common. Patients who were older and has high PSA density requires more detailed discussion on active surveillance and consider repeat biopsy before decide on the treatment of prostate cancer.
DescriptionConference Theme: Urological Advancement in Asia
Abstract and Poster Presentation
This free journal suppl. entitled: Special Issue: 14th Urological Association of Asia Congress 2016 Singapore
Persistent Identifierhttp://hdl.handle.net/10722/235195
ISSN
2015 Impact Factor: 1.878
2015 SCImago Journal Rankings: 0.841

 

DC FieldValueLanguage
dc.contributor.authorChan, YS-
dc.contributor.authorYiu, MK-
dc.contributor.authorLai, TCT-
dc.contributor.authorTsang, CF-
dc.contributor.authorWong, CKW-
dc.contributor.authorHo, SHB-
dc.contributor.authorNg, ATL-
dc.contributor.authorTsu, HLJ-
dc.contributor.authorMa, WK-
dc.date.accessioned2016-10-14T13:51:51Z-
dc.date.available2016-10-14T13:51:51Z-
dc.date.issued2016-
dc.identifier.citationThe 14th Urological Association of Asia Congress (UAA 2016) in conjunction with UROFAIR 2016, Urology Residents' Course 2016, and the 30th Anniversary of the Singapore Urological Association, Singapore, 20-24 July 2016. In International Journal of Urology, 2016, v. 23 suppl. S1, p. 68, abstract no. C-OPRO-4492-
dc.identifier.issn0919-8172-
dc.identifier.urihttp://hdl.handle.net/10722/235195-
dc.descriptionConference Theme: Urological Advancement in Asia-
dc.descriptionAbstract and Poster Presentation-
dc.descriptionThis free journal suppl. entitled: Special Issue: 14th Urological Association of Asia Congress 2016 Singapore-
dc.description.abstractOBJECTIVES Review the pathology of radical prostatectomy (RP) and investigate patients who were eligible for active surveillance (AS) on preoperative investigations and assess any pathological and radiological upstage of prostate cancer. METHODS A total of 158 patient underwent radical prostatectomy (RP) from September, 2011 to October, 2015 in Queen Mary Hospital were retrospectively reviewed. Baseline characteristics, transrectal ultrasound (TRUS) biopsy details, magnetic resonance imaging (MRI) and RP pathology were analysed. Univariate and multivariate analyses were used to identify any significant predictors of upstaged disease. RESULTS There were 48 patients fulfilled the Memorial Sloan Kettering Cancer Centre (MSKCC) criteria for AS. The accuracy of TRUS biopsy in predicting Gleason score and MRI in predicting extra-capsular disease were 52% and 95% respectively. The positive predictive value (PPV), negative predictive value (NPV), sensitivity, specificity and accuracy of TRUS biopsy, MRI and combination of TRUS biopsy and MRI for laterality of disease are 16%, 100%, 100%, 5%, 19%; 23%,92%, 88%, 34%, 44% and 21%, 93%, 88%, 35%, 44% respectively. 46% of patients have upstaged disease with 15% were high risk prostate cancer. Age (HR 1.12, P = 0.025) and PSA density (HR 2.12, P = 0.017) were independent predictors on both univariate and multivariate analyses. CONCLUSION Both TRUS biopsy and MRI have a low positive predictive in low risks prostate cancer and significant upstaging in final pathology is common. Patients who were older and has high PSA density requires more detailed discussion on active surveillance and consider repeat biopsy before decide on the treatment of prostate cancer.-
dc.languageeng-
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJU-
dc.relation.ispartofInternational Journal of Urology-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.titleWill intermediate or high risks prostate cancer patients be mistakenly assigned into active surveillance programme? A retrospective review in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailYiu, MK: pmkyiu@hku.hk-
dc.identifier.emailWong, CKW: kwwongab@hku.hk-
dc.identifier.emailTsu, HLJ: jamestsu@hku.hk-
dc.identifier.emailMa, WK: mwk054@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/iju.13149-
dc.identifier.hkuros270377-
dc.identifier.volume23-
dc.identifier.issuesuppl. S1-
dc.identifier.spage68, abstract no. C-OPRO-4492-
dc.identifier.epage68, abstract no. C-OPRO-4492-
dc.publisher.placeAustralia-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats