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Conference Paper: Effect of the hepatitis B core protein C-terminal domain mutations on HBV transcription

TitleEffect of the hepatitis B core protein C-terminal domain mutations on HBV transcription
Authors
Issue Date2016
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The International Liver Congress™ 2016 - The 51st Annual Meeting of the European Association for the Study of the Liver (EASL 2016), Barcelona, Spain, 13-17 April, 2016. In Journal of Hepatology, 2016, v. 64 n. 2 suppl., p. S386, abstract no. THU-181 How to Cite?
AbstractBACKGROUND AND AIMS: The hepatitis B core protein (HBc) is a component of the HBV covalently closed circular DNA (cccDNA) minichromosome, the transcription template of HBV. The HBc C-terminal domain (CTD) contains an arginine-rich region, which has been shown to be responsible for nucleic acid binding and efficient HBV RNA encapsidation and reverse transcription. It has been implicated that HBV transcription is regulated by the association of HBc to cccDNA. However, direct evidence demonstrating the effect of HBc on HBV transcription is lacking. We aimed to study the effect of HBc mutations on HBV transcription using a cccDNA-dependent study system …
DescriptionPoster Presentations: Viral hepatitis: Hepatitis B & D – experimental: no. THU-181
Persistent Identifierhttp://hdl.handle.net/10722/234184
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorChong, CK-
dc.contributor.authorCheng, CYS-
dc.contributor.authorTsoi, SY-
dc.contributor.authorHuang, FY-
dc.contributor.authorSeto, WKW-
dc.contributor.authorLai, CL-
dc.contributor.authorYuen, RMF-
dc.contributor.authorWong, DKH-
dc.date.accessioned2016-10-14T06:59:40Z-
dc.date.available2016-10-14T06:59:40Z-
dc.date.issued2016-
dc.identifier.citationThe International Liver Congress™ 2016 - The 51st Annual Meeting of the European Association for the Study of the Liver (EASL 2016), Barcelona, Spain, 13-17 April, 2016. In Journal of Hepatology, 2016, v. 64 n. 2 suppl., p. S386, abstract no. THU-181-
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/234184-
dc.descriptionPoster Presentations: Viral hepatitis: Hepatitis B & D – experimental: no. THU-181-
dc.description.abstractBACKGROUND AND AIMS: The hepatitis B core protein (HBc) is a component of the HBV covalently closed circular DNA (cccDNA) minichromosome, the transcription template of HBV. The HBc C-terminal domain (CTD) contains an arginine-rich region, which has been shown to be responsible for nucleic acid binding and efficient HBV RNA encapsidation and reverse transcription. It has been implicated that HBV transcription is regulated by the association of HBc to cccDNA. However, direct evidence demonstrating the effect of HBc on HBV transcription is lacking. We aimed to study the effect of HBc mutations on HBV transcription using a cccDNA-dependent study system …-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatology-
dc.rights© 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleEffect of the hepatitis B core protein C-terminal domain mutations on HBV transcription-
dc.typeConference_Paper-
dc.identifier.emailCheng, CYS: serenecy@hku.hk-
dc.identifier.emailTsoi, SY: jastsoi@hku.hk-
dc.identifier.emailHuang, FY: fungyu@hkucc.hku.hk-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hkucc.hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityYuen, RMF=rp00479-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.doi10.1016/S0168-8278(16)00594-8-
dc.identifier.hkuros267698-
dc.identifier.volume64-
dc.identifier.issue2 suppl.-
dc.identifier.spageS386, abstract no. THU-181-
dc.identifier.epageS386, abstract no. THU-181-
dc.publisher.placeThe Netherlands-

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