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Article: Biomarkers for predicting future metastasis of human gastrointestinal tumors

TitleBiomarkers for predicting future metastasis of human gastrointestinal tumors
Authors
KeywordsColorectal cancer
Pancreatic cancer
Metastasis
Hepatocellular carcinoma
Gastric cancer
Esophageal cancer
Issue Date2013
Citation
Cellular and Molecular Life Sciences, 2013, v. 70, n. 19, p. 3631-3656 How to Cite?
AbstractThe recent advances in surgery and radiation therapy have significantly improved the prognosis of patients with primary cancer, and the major challenge of cancer treatment now is metastatic disease development. The 5-year survival rate of cancer patients who have distant metastasis at diagnosis is extremely low, suggesting that prediction and early detection of metastasis would definitely improve their prognosis because suitable patient therapeutic management and treatment strategy can be provided. Cancer cells from a primary site give rise to a metastatic tumor via a number of steps which require the involvement and altered expression of many regulators. These regulators may serve as biomarkers for predicting metastasis. Over the past few years, numerous regulators have been found correlating with metastasis. In this review, we summarize the findings of a number of potential biomarkers that are involved in cadherin-catenin interaction, integrin signaling, PI3K/Akt/mTOR signaling and cancer stem cell identification in gastrointestinal cancers. We will also discuss how certain biomarkers are associated with the tumor microenvironment that favors cancer metastasis. © 2013 Springer Basel.
Persistent Identifierhttp://hdl.handle.net/10722/233827
ISSN
2015 Impact Factor: 5.694
2015 SCImago Journal Rankings: 3.388

 

DC FieldValueLanguage
dc.contributor.authorNg, Lui-
dc.contributor.authorPoon, Ronnie Tung Ping-
dc.contributor.authorPang, Roberta-
dc.date.accessioned2016-09-27T07:21:45Z-
dc.date.available2016-09-27T07:21:45Z-
dc.date.issued2013-
dc.identifier.citationCellular and Molecular Life Sciences, 2013, v. 70, n. 19, p. 3631-3656-
dc.identifier.issn1420-682X-
dc.identifier.urihttp://hdl.handle.net/10722/233827-
dc.description.abstractThe recent advances in surgery and radiation therapy have significantly improved the prognosis of patients with primary cancer, and the major challenge of cancer treatment now is metastatic disease development. The 5-year survival rate of cancer patients who have distant metastasis at diagnosis is extremely low, suggesting that prediction and early detection of metastasis would definitely improve their prognosis because suitable patient therapeutic management and treatment strategy can be provided. Cancer cells from a primary site give rise to a metastatic tumor via a number of steps which require the involvement and altered expression of many regulators. These regulators may serve as biomarkers for predicting metastasis. Over the past few years, numerous regulators have been found correlating with metastasis. In this review, we summarize the findings of a number of potential biomarkers that are involved in cadherin-catenin interaction, integrin signaling, PI3K/Akt/mTOR signaling and cancer stem cell identification in gastrointestinal cancers. We will also discuss how certain biomarkers are associated with the tumor microenvironment that favors cancer metastasis. © 2013 Springer Basel.-
dc.languageeng-
dc.relation.ispartofCellular and Molecular Life Sciences-
dc.subjectColorectal cancer-
dc.subjectPancreatic cancer-
dc.subjectMetastasis-
dc.subjectHepatocellular carcinoma-
dc.subjectGastric cancer-
dc.subjectEsophageal cancer-
dc.titleBiomarkers for predicting future metastasis of human gastrointestinal tumors-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00018-013-1266-8-
dc.identifier.scopuseid_2-s2.0-84884349464-
dc.identifier.hkuros213831-
dc.identifier.volume70-
dc.identifier.issue19-
dc.identifier.spage3631-
dc.identifier.epage3656-
dc.identifier.eissn1420-9071-

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