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Article: Role of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas

TitleRole of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas
Authors
KeywordsHead and neck cancer
NF-κB
Proteome
Signal pathways
Transcriptome
Issue Date2008
PublisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/bmm
Citation
Biomarkers in Medicine, 2008, v. 2 n. 4, p. 409-429 How to Cite?
AbstractNF-κB is a family of signal-activated transcription factors comprising hetero- or homodimers from five different subunits, NF-κB1, NF-κB2, RELA, cREL and RELB. NF-κBs are normally transiently activated in response to infection or injury, but in cancers are aberrantly activated, regulating a transcriptome of hundreds of genes and corresponding proteome that promote pathogenesis and therapeutic resistance. In head and neck squamous cell carcinomas, an important role of NF-κB in the regulation of the altered transcriptome and proteome has been established, providing a catalog of activating and target genes and proteins that may be useful as biomarkers of alterations in this pathway for this and other cancers. An emerging appreciation that NF-κB and other signal pathways form an altered regulatory network highlights the need to use biomarkers and combine targeted agents for personalized therapy of cancer.
Persistent Identifierhttp://hdl.handle.net/10722/233708
ISSN
2015 Impact Factor: 2.179
2015 SCImago Journal Rankings: 0.834

 

DC FieldValueLanguage
dc.contributor.authorChen, Z-
dc.contributor.authorYan, B-
dc.contributor.authorVan Waes, C-
dc.date.accessioned2016-09-20T06:28:36Z-
dc.date.available2016-09-20T06:28:36Z-
dc.date.issued2008-
dc.identifier.citationBiomarkers in Medicine, 2008, v. 2 n. 4, p. 409-429-
dc.identifier.issn1752-0363-
dc.identifier.urihttp://hdl.handle.net/10722/233708-
dc.description.abstractNF-κB is a family of signal-activated transcription factors comprising hetero- or homodimers from five different subunits, NF-κB1, NF-κB2, RELA, cREL and RELB. NF-κBs are normally transiently activated in response to infection or injury, but in cancers are aberrantly activated, regulating a transcriptome of hundreds of genes and corresponding proteome that promote pathogenesis and therapeutic resistance. In head and neck squamous cell carcinomas, an important role of NF-κB in the regulation of the altered transcriptome and proteome has been established, providing a catalog of activating and target genes and proteins that may be useful as biomarkers of alterations in this pathway for this and other cancers. An emerging appreciation that NF-κB and other signal pathways form an altered regulatory network highlights the need to use biomarkers and combine targeted agents for personalized therapy of cancer.-
dc.languageeng-
dc.publisherFuture Medicine Ltd. The Journal's web site is located at http://www.futuremedicine.com/loi/bmm-
dc.relation.ispartofBiomarkers in Medicine-
dc.rightsManuscripts that have been submitted for publication and entry into peer review-
dc.subjectHead and neck cancer-
dc.subjectNF-κB-
dc.subjectProteome-
dc.subjectSignal pathways-
dc.subjectTranscriptome-
dc.titleRole of the NF-κB transcriptome and proteome as biomarkers human head and neck squamous cell carcinomas-
dc.typeArticle-
dc.identifier.emailYan, B: yanbin14@hku.hk-
dc.identifier.authorityYan, B=rp01940-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2217/17520363.2.4.409-
dc.identifier.scopuseid_2-s2.0-54849417812-
dc.identifier.volume2-
dc.identifier.issue4-
dc.identifier.spage409-
dc.identifier.epage429-
dc.publisher.placeUnited Kingdom-

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