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Conference Paper: Applicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules

TitleApplicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules
Authors
Issue Date2016
PublisherSage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=263
Citation
The 16th Biennial European Conference of the Society for Medical Decision Making (SMDM-European Conference 2016), London, UK., 12-16 June 2016. In Medical Decision Making, 2016, v. 36 n. 7, p. E510-E511 How to Cite?
AbstractPURPOSE: The aim of this study was to examine the acceptability, validity and reliability of utility measures and cancer-specific health-related quality of life (HRQOL) in Chinese patients diagnosed with incidental thyroid nodules. METHOD(s): Data from a randomized controlled trial (ClinicalTrials.gov Identifier: NCT02398721) of 314 patients diagnosed with incidental thyroid nodules were utilized for this psychometric evaluation of HRQOL measurement. Three HRQOL questionnaires, cancer-specific Functional Assessment of Cancer Therapy-general (FACT-G) and generic 12-item Short Form Health Survey (SF-12v2) and 6-item Short Form Health Survey (SF-6D), were administered through face-to-face interviews at both baseline and 2-week after baseline. Responses to SF-6D were transformed to SF-6D utility scores using Hong Kong standard gamble value set. Construct validity was determined by evaluating the extent to overlap SF-12v2 dimensions across HRQOL instruments by Spearman rank correlation. Internal consistency and 2-week test-retest reliability was assessed using Cronbach’s α coefficient and intra-class correlation coefficient, respectively. RESULT(s): No significant (>15%) floor and ceiling effects were observed for FACT-G subscale and total scores. The SF-6D utility scores and FACT-G subscale scores had a moderate Spearman rank correlation with the corresponding SF-12v2 domain score that conceptually measures the similar construct providing evidence for adequate construct validity. Internal consistency of the FACT-G subscales and total scales were acceptable (α: 0.639-0.850) for all subscales aside from the Emotional well-being subscale (α: 0.581). The HRQOL and utility scores showed excellent test-retest reliability (range: 0.758-0.858). CONCLUSION(s): The SF-6D utility score and cancer-specific FACT-G questionnaire appears to be a valid and reliable measure to assess the HRQOL of Chinese patients diagnosed with incidental thyroid nodules, and thus evaluate the treatment response to those patients.
DescriptionPoster Session 3: no. PS3-20
Persistent Identifierhttp://hdl.handle.net/10722/233623
ISSN
2015 Impact Factor: 2.908
2015 SCImago Journal Rankings: 1.864

 

DC FieldValueLanguage
dc.contributor.authorWong, CKH-
dc.contributor.authorLang, HHB-
dc.date.accessioned2016-09-20T05:38:02Z-
dc.date.available2016-09-20T05:38:02Z-
dc.date.issued2016-
dc.identifier.citationThe 16th Biennial European Conference of the Society for Medical Decision Making (SMDM-European Conference 2016), London, UK., 12-16 June 2016. In Medical Decision Making, 2016, v. 36 n. 7, p. E510-E511-
dc.identifier.issn0272-989X-
dc.identifier.urihttp://hdl.handle.net/10722/233623-
dc.descriptionPoster Session 3: no. PS3-20-
dc.description.abstractPURPOSE: The aim of this study was to examine the acceptability, validity and reliability of utility measures and cancer-specific health-related quality of life (HRQOL) in Chinese patients diagnosed with incidental thyroid nodules. METHOD(s): Data from a randomized controlled trial (ClinicalTrials.gov Identifier: NCT02398721) of 314 patients diagnosed with incidental thyroid nodules were utilized for this psychometric evaluation of HRQOL measurement. Three HRQOL questionnaires, cancer-specific Functional Assessment of Cancer Therapy-general (FACT-G) and generic 12-item Short Form Health Survey (SF-12v2) and 6-item Short Form Health Survey (SF-6D), were administered through face-to-face interviews at both baseline and 2-week after baseline. Responses to SF-6D were transformed to SF-6D utility scores using Hong Kong standard gamble value set. Construct validity was determined by evaluating the extent to overlap SF-12v2 dimensions across HRQOL instruments by Spearman rank correlation. Internal consistency and 2-week test-retest reliability was assessed using Cronbach’s α coefficient and intra-class correlation coefficient, respectively. RESULT(s): No significant (>15%) floor and ceiling effects were observed for FACT-G subscale and total scores. The SF-6D utility scores and FACT-G subscale scores had a moderate Spearman rank correlation with the corresponding SF-12v2 domain score that conceptually measures the similar construct providing evidence for adequate construct validity. Internal consistency of the FACT-G subscales and total scales were acceptable (α: 0.639-0.850) for all subscales aside from the Emotional well-being subscale (α: 0.581). The HRQOL and utility scores showed excellent test-retest reliability (range: 0.758-0.858). CONCLUSION(s): The SF-6D utility score and cancer-specific FACT-G questionnaire appears to be a valid and reliable measure to assess the HRQOL of Chinese patients diagnosed with incidental thyroid nodules, and thus evaluate the treatment response to those patients.-
dc.languageeng-
dc.publisherSage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=263-
dc.relation.ispartofMedical Decision Making-
dc.rightsMedical Decision Making. Copyright © Sage Science Press (US).-
dc.titleApplicability and Psychometric Evaluation of Utility and Cancer-Specific Health-Related Quality of Life Measures in patients with Incidental Thyroid Nodules-
dc.typeConference_Paper-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.emailLang, HHB: blang@hkucc.hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.identifier.authorityLang, HHB=rp01828-
dc.identifier.doi10.1177/0272989X16665121-
dc.identifier.hkuros266419-
dc.identifier.volume36-
dc.identifier.issue7-
dc.identifier.spageE510-
dc.identifier.epageE511-
dc.publisher.placeUnited States-

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