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Conference Paper: Elderly heart failure with preserved ejection fraction showed different predictors for cardiovascular mortality than their younger counterparts

TitleElderly heart failure with preserved ejection fraction showed different predictors for cardiovascular mortality than their younger counterparts
European Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 842
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
The 2015 Annual Congress of the European Society of Cardiology (ESC), London, UK., 29 August-2 September 2015. In European Heart Journal, 2015, v. 36 suppl. 1, p. 842 How to Cite?
AbstractBACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFPEF) has been shown to be more common among the elderly population. Nevertheless, little is known about the clinical characteristics and outcomes specific for this population. METHODS: We retrospectively reviewed 1,940 patients who had their first heart failure admission to our institution between January 2005 and April 2012. Clinical characteristics and outcomes of patients who were ≥70 years of age and had HFPEF, as defined by left ventricular ejection fraction (LVEF) ≥40%, were compared to those who were <70 years of age. Parameters predictive of cardiovascular mortality were studied in a Cox-regression model. RESULTS: Among the 569 patients with HFPEF, 109 (19.2%) were <70 and 460 (80.8%) were ≥70 years old. Compared with those who were <70, patients who were ≥70 were more likely to be female (60.9% vs 46.8%, p=0.009) and have hypertension (75.4% vs 56.9%, p<0.001), but less likely to have diabetes (35.9% vs 49.5%, p=0.01). At a mean follow-up of 35.8±30.2 months, 175 (38.0%) of those who were ≥70 years old and 44 (40.4%) of those who were <70 years old died, of whom 112 (24.3%) and 20 (18.3%) of them died of cardiovascular cause, respectively (log rank test p=0.06). Multivariate model showed that age (HR 1.88 per decade, 95% CI 1.45–2.43, p=0.006), LVEF <50% (HR 2.11, 95% CI 1.24–3.59, p=0.006), systolic blood pressure on admission (HR 0.992, 95% CI 0.986–0.999, p=0.02) and aldosterone antagonist (HR 5.79, 95% CI 2.09–16.03, p=0.001) independently predicted cardiovascular mortality among those who were ≥70 years old, while only smoking history (HR 3.34, 95% CI 1.39–8.03, p=0.007) was found to be predictive of cardiovascular mortality among those who were <70 years old. CONCLUSION: Elderly patients ≥70 years of age who had HFPEF showed similar survival to but different predictors for cardiovascular mortality than their younger counterparts, reflecting potentially different contributing factors to cardiovascular mortality between the two groups of patients. Development of risk model that assesses clinical risk factors and effect of treatment specific for this group of patients can improve their management.
DescriptionPoster Session 5 - Basic mechanisms, ventricular function, prognosis 2: no. P4765
This journal suppl. entitled: ESC Congress 2015, London, United Kingdom, 29 August-2 September 2015
Persistent Identifierhttp://hdl.handle.net/10722/232412
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorHai, SHJJ-
dc.contributor.authorChan, PHM-
dc.contributor.authorTse, HF-
dc.contributor.authorSiu, CW-
dc.date.accessioned2016-09-20T05:29:48Z-
dc.date.available2016-09-20T05:29:48Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Annual Congress of the European Society of Cardiology (ESC), London, UK., 29 August-2 September 2015. In European Heart Journal, 2015, v. 36 suppl. 1, p. 842-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/232412-
dc.descriptionPoster Session 5 - Basic mechanisms, ventricular function, prognosis 2: no. P4765-
dc.descriptionThis journal suppl. entitled: ESC Congress 2015, London, United Kingdom, 29 August-2 September 2015-
dc.description.abstractBACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFPEF) has been shown to be more common among the elderly population. Nevertheless, little is known about the clinical characteristics and outcomes specific for this population. METHODS: We retrospectively reviewed 1,940 patients who had their first heart failure admission to our institution between January 2005 and April 2012. Clinical characteristics and outcomes of patients who were ≥70 years of age and had HFPEF, as defined by left ventricular ejection fraction (LVEF) ≥40%, were compared to those who were <70 years of age. Parameters predictive of cardiovascular mortality were studied in a Cox-regression model. RESULTS: Among the 569 patients with HFPEF, 109 (19.2%) were <70 and 460 (80.8%) were ≥70 years old. Compared with those who were <70, patients who were ≥70 were more likely to be female (60.9% vs 46.8%, p=0.009) and have hypertension (75.4% vs 56.9%, p<0.001), but less likely to have diabetes (35.9% vs 49.5%, p=0.01). At a mean follow-up of 35.8±30.2 months, 175 (38.0%) of those who were ≥70 years old and 44 (40.4%) of those who were <70 years old died, of whom 112 (24.3%) and 20 (18.3%) of them died of cardiovascular cause, respectively (log rank test p=0.06). Multivariate model showed that age (HR 1.88 per decade, 95% CI 1.45–2.43, p=0.006), LVEF <50% (HR 2.11, 95% CI 1.24–3.59, p=0.006), systolic blood pressure on admission (HR 0.992, 95% CI 0.986–0.999, p=0.02) and aldosterone antagonist (HR 5.79, 95% CI 2.09–16.03, p=0.001) independently predicted cardiovascular mortality among those who were ≥70 years old, while only smoking history (HR 3.34, 95% CI 1.39–8.03, p=0.007) was found to be predictive of cardiovascular mortality among those who were <70 years old. CONCLUSION: Elderly patients ≥70 years of age who had HFPEF showed similar survival to but different predictors for cardiovascular mortality than their younger counterparts, reflecting potentially different contributing factors to cardiovascular mortality between the two groups of patients. Development of risk model that assesses clinical risk factors and effect of treatment specific for this group of patients can improve their management.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleElderly heart failure with preserved ejection fraction showed different predictors for cardiovascular mortality than their younger counterparts-
dc.titleEuropean Heart Journal ( 2015 ) 36 ( Abstract Supplement ), 842-
dc.typeConference_Paper-
dc.identifier.emailHai, SHJJ: haishjj@hku.hk-
dc.identifier.emailChan, PHM: phmchan@hku.hk-
dc.identifier.emailTse, HF: hftse@hku.hk-
dc.identifier.emailSiu, CW: cwdsiu@hkucc.hku.hk-
dc.identifier.authorityHai, SHJJ=rp02047-
dc.identifier.authorityChan, PHM=rp01864-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authoritySiu, CW=rp00534-
dc.identifier.doi10.1093/eurheartj/ehv400-
dc.identifier.hkuros264643-
dc.identifier.volume36-
dc.identifier.issuesuppl. 1-
dc.identifier.spage842-
dc.identifier.epage842-
dc.publisher.placeUnited Kingdom-

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