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Conference Paper: Biventricular dysfunction in patients with liver cirrhosis

TitleBiventricular dysfunction in patients with liver cirrhosis
Authors
Issue Date2014
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
The 2014 Annual Congress of the European Society of Cardiology (ESC), Barcelona, Spain, 30 August-3 September 2014., v. 35 suppl. 1, p. 627, abstarct P3482 How to Cite?
AbstractOBJECTIVE: Patient with liver cirrhosis is associated with left ventricular (LV) myocardial dysfunction. However, studies on the right ventricular (RV) function in these patients are limited. The aim of this study thus was to evaluate both LV and RV function in patients with cirrhosis. METHODS: A total of 103 cirrhosis patients (age 54.9±7.3 years, 74.8% male) and 48 age- and gender-matched healthy controls were included. Detail transthoracic echocardiography were performed in all subjects. Conventional echocardiography parameters including LV dimension, LV ejection fraction, RV dimension and RV systolic function assessed by tricuspid annular plane systolic excursion (TAPSE) were measured. In addition, advanced speckle-tracking derived strain analysis to detect subtle LV and RV systolic dysfunction were measured. Global LV strains were assessed from three orthogonal directions: longitudinal (LS), circumferential (CS), and radial strain (RS). Global RV longitudinal strain (RV-LS) including the RV free wall and septum were measured. RESULTS: Both LV and RV dimension were comparable between patients with cirrhosis and controls. Despite similar LV ejection fraction (65.1±4.8% vs. 64.1±4.4%; P=0.193) and TAPSE (2.37±0.43 vs. 2.34±0.24; P=0.592), patients with cirrhosis had impaired global LS (-18.5±2.9% vs. -20.1±2.8%, P<0.01), CS (-16.6±2.4% vs. -21.6±3.6%, P<0.01), RS (39.9±13.1% vs. 44.9±14.3%, P<0.05) and RV-LS (-21.2±4.4% vs. -23.0±2.6%, P<0.01) compared with controls. Upon multivariable adjustment with age, gender and cardiovascular risk factors, both global LV and RV strains remained significantly impaired in patients with cirrhosis. CONCLUSIONS: In addition to impaired LV systolic function, the present study firstly demonstrated that patients with cirrhosis had concomitant RV systolic dysfunction assessed by speckle tracking derived strain. This data thus suggested patients with cirrhosis had biventricular myocardial dysfunction.
DescriptionPoster Session - Right Ventricular Function: no. P3482
This journal suppl. entitled: ESC Congress 2014, Barcelona, Spain, 30 August-3 September 2014
Persistent Identifierhttp://hdl.handle.net/10722/232393
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorChen, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2016-09-20T05:29:40Z-
dc.date.available2016-09-20T05:29:40Z-
dc.date.issued2014-
dc.identifier.citationThe 2014 Annual Congress of the European Society of Cardiology (ESC), Barcelona, Spain, 30 August-3 September 2014., v. 35 suppl. 1, p. 627, abstarct P3482-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/232393-
dc.descriptionPoster Session - Right Ventricular Function: no. P3482-
dc.descriptionThis journal suppl. entitled: ESC Congress 2014, Barcelona, Spain, 30 August-3 September 2014-
dc.description.abstractOBJECTIVE: Patient with liver cirrhosis is associated with left ventricular (LV) myocardial dysfunction. However, studies on the right ventricular (RV) function in these patients are limited. The aim of this study thus was to evaluate both LV and RV function in patients with cirrhosis. METHODS: A total of 103 cirrhosis patients (age 54.9±7.3 years, 74.8% male) and 48 age- and gender-matched healthy controls were included. Detail transthoracic echocardiography were performed in all subjects. Conventional echocardiography parameters including LV dimension, LV ejection fraction, RV dimension and RV systolic function assessed by tricuspid annular plane systolic excursion (TAPSE) were measured. In addition, advanced speckle-tracking derived strain analysis to detect subtle LV and RV systolic dysfunction were measured. Global LV strains were assessed from three orthogonal directions: longitudinal (LS), circumferential (CS), and radial strain (RS). Global RV longitudinal strain (RV-LS) including the RV free wall and septum were measured. RESULTS: Both LV and RV dimension were comparable between patients with cirrhosis and controls. Despite similar LV ejection fraction (65.1±4.8% vs. 64.1±4.4%; P=0.193) and TAPSE (2.37±0.43 vs. 2.34±0.24; P=0.592), patients with cirrhosis had impaired global LS (-18.5±2.9% vs. -20.1±2.8%, P<0.01), CS (-16.6±2.4% vs. -21.6±3.6%, P<0.01), RS (39.9±13.1% vs. 44.9±14.3%, P<0.05) and RV-LS (-21.2±4.4% vs. -23.0±2.6%, P<0.01) compared with controls. Upon multivariable adjustment with age, gender and cardiovascular risk factors, both global LV and RV strains remained significantly impaired in patients with cirrhosis. CONCLUSIONS: In addition to impaired LV systolic function, the present study firstly demonstrated that patients with cirrhosis had concomitant RV systolic dysfunction assessed by speckle tracking derived strain. This data thus suggested patients with cirrhosis had biventricular myocardial dysfunction.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleBiventricular dysfunction in patients with liver cirrhosis-
dc.typeConference_Paper-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.doi10.1093/eurheartj/ehu324-
dc.identifier.hkuros263225-
dc.identifier.volume35-
dc.identifier.issuesuppl. 1-
dc.identifier.spage627, abstarct P3482-
dc.identifier.epage627, abstarct P3482-
dc.publisher.placeUnited Kingdom-

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