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Article: Immunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia

TitleImmunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia
Authors
Issue Date2016
PublisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html
Citation
Oncotarget, 2016, v. 7 n. 15, p. 20520-20531 How to Cite?
AbstractChronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world, whereas in Asia the incidence is about 10 times lower. The basis for this ethnic and geographic variation is currently unknown. The aim of this study was to characterize IGHVDJ rearrangements and stereotype of the HCDR3 region in a series of 623 Chinese CLL, in order to identify possible differences in immunoglobulin gene usage and their potential pathogenetic implications. Chinese CLL were compared to 789 Italian CLL. Chinese patients showed a higher proportion of mutated IGHV and a more frequent usage of IGHV3-7, IGHV3-74, IGHV4-39 and IGHV4-59 genes. A significantly lower usage of IGHV1-69 and IGHV1-2 was documented, with comparable IGHV3-21 frequency (3% Chinese vs 3.8% Italian CLL). The proportion of known stereotyped receptors was significantly lower in Chinese (19.7%) than in Italian CLL (25.8%), despite a significantly higher frequency of subset #8 (p= 0.0001). Moreover, new paired clusters were identified among Chinese cases. Overall, these data support a potential different antigenic exposure between Eastern and Western CLL.
Persistent Identifierhttp://hdl.handle.net/10722/232069
ISSN
2015 Impact Factor: 5.008
2015 SCImago Journal Rankings: 2.294

 

DC FieldValueLanguage
dc.contributor.authorMarinelli, M-
dc.contributor.authorIlari, I-
dc.contributor.authorXia, Y-
dc.contributor.authorGiudice, ID-
dc.contributor.authorCafforio, L-
dc.contributor.authorStarza, ID-
dc.contributor.authorRaponi, S-
dc.contributor.authorMariglia, P-
dc.contributor.authorBonina, S-
dc.contributor.authorYU, Z-
dc.contributor.authorYANG, W-
dc.contributor.authorQIU, L-
dc.contributor.authorChan, SYT-
dc.contributor.authorPiciocchi, A-
dc.contributor.authorKwong, YL-
dc.contributor.authorTse, EWC-
dc.contributor.authorLi, J-
dc.contributor.authorGuarini, A-
dc.contributor.authorXU, W-
dc.contributor.authorFoà, R-
dc.date.accessioned2016-09-20T05:27:30Z-
dc.date.available2016-09-20T05:27:30Z-
dc.date.issued2016-
dc.identifier.citationOncotarget, 2016, v. 7 n. 15, p. 20520-20531-
dc.identifier.issn1949-2553-
dc.identifier.urihttp://hdl.handle.net/10722/232069-
dc.description.abstractChronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world, whereas in Asia the incidence is about 10 times lower. The basis for this ethnic and geographic variation is currently unknown. The aim of this study was to characterize IGHVDJ rearrangements and stereotype of the HCDR3 region in a series of 623 Chinese CLL, in order to identify possible differences in immunoglobulin gene usage and their potential pathogenetic implications. Chinese CLL were compared to 789 Italian CLL. Chinese patients showed a higher proportion of mutated IGHV and a more frequent usage of IGHV3-7, IGHV3-74, IGHV4-39 and IGHV4-59 genes. A significantly lower usage of IGHV1-69 and IGHV1-2 was documented, with comparable IGHV3-21 frequency (3% Chinese vs 3.8% Italian CLL). The proportion of known stereotyped receptors was significantly lower in Chinese (19.7%) than in Italian CLL (25.8%), despite a significantly higher frequency of subset #8 (p= 0.0001). Moreover, new paired clusters were identified among Chinese cases. Overall, these data support a potential different antigenic exposure between Eastern and Western CLL.-
dc.languageeng-
dc.publisherImpact Journals LLC. The Journal's web site is located at http://www.impactjournals.com/oncotarget/index.html-
dc.relation.ispartofOncotarget-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleImmunoglobulin gene rearrangements in Chinese and Italian patients with chronic lymphocytic leukemia-
dc.typeArticle-
dc.identifier.emailChan, SYT: drtchan@hku.hk-
dc.identifier.emailKwong, YL: ylkwong@hkucc.hku.hk-
dc.identifier.emailTse, EWC: ewctse@hku.hk-
dc.identifier.authorityKwong, YL=rp00358-
dc.identifier.authorityTse, EWC=rp00471-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.18632/oncotarget.7819-
dc.identifier.hkuros266581-
dc.identifier.volume7-
dc.identifier.issue15-
dc.identifier.spage20520-
dc.identifier.epage20531-
dc.publisher.placeUnited States-

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