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Conference Paper: Fluoxetine induces restoration of plasticity in the adult vestibular system

TitleFluoxetine induces restoration of plasticity in the adult vestibular system
Authors
Issue Date2015
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1471-4159
Citation
The 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, Australia, 23–27 August 2015. In Journal of Neurochemistry, 2015, v. 134 n. S1, p. 158, abstract no. MTU07-15 How to Cite?
AbstractAntidepressant fluoxetine is known to restore neuronal plasticity in the adult visual cortex by modulating GABA level. We hypothesize that fluoxetine also reinstates plasticity in the adult vestibular nucleus (VN) by altering GABAergic transmission. We previously showed that derangement of spatial navigation in adult rats was observed with neonatal blockade of GABAA receptor (GABAAR) in the VN but not with blockade applied after P14. In the present study, we demonstrated that deficits in spatial navigation could still be induced in adult rats that received both bicuculline treatment in the VN and oral administration of fluoxetine from P21 onwards. This implies that fluoxetine restores the plasticity observed in critical period during which bicuculline induces deficits in spatial navigation. With western blot analysis, we found that oral administration of fluoxetine during P21–28 significantly reduced protein expression of potassium-chloride co-transporter (KCC2) in the VN. Since KCC2 is responsible for the extrusion of chloride ions, lower level of KCC2 expression indicates less chloride ions flowing through GABAAR, causing a reduction in the impact of inhibitory GABAergic transmission. The latter is corroborated with the observation that the proportion of VN neurons exhibiting GABAAR-mediated long-term depression (LTD) was significantly increased from 34.6% in controls to 50% in P28 rats pre-treated with fluoxetine during P21–28. These results imply that fluoxetine induces a reduction in GABAergic transmission, thus contributing to the restoration of the plasticity observed in critical period. [Supported by HKU 761812M].
DescriptionThis free journal suppl. entitled: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society 23–27 August 2015, Cairns, Australia
Poster Sessions Monday/Tuesday: no. MTU07-15
Persistent Identifierhttp://hdl.handle.net/10722/231569
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021

 

DC FieldValueLanguage
dc.contributor.authorJiang, Q-
dc.contributor.authorMa, CW-
dc.contributor.authorChen, W-
dc.contributor.authorShum, DKY-
dc.contributor.authorChan, YS-
dc.date.accessioned2016-09-20T05:24:03Z-
dc.date.available2016-09-20T05:24:03Z-
dc.date.issued2015-
dc.identifier.citationThe 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, Australia, 23–27 August 2015. In Journal of Neurochemistry, 2015, v. 134 n. S1, p. 158, abstract no. MTU07-15-
dc.identifier.issn0022-3042-
dc.identifier.urihttp://hdl.handle.net/10722/231569-
dc.descriptionThis free journal suppl. entitled: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian-Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society 23–27 August 2015, Cairns, Australia-
dc.descriptionPoster Sessions Monday/Tuesday: no. MTU07-15-
dc.description.abstractAntidepressant fluoxetine is known to restore neuronal plasticity in the adult visual cortex by modulating GABA level. We hypothesize that fluoxetine also reinstates plasticity in the adult vestibular nucleus (VN) by altering GABAergic transmission. We previously showed that derangement of spatial navigation in adult rats was observed with neonatal blockade of GABAA receptor (GABAAR) in the VN but not with blockade applied after P14. In the present study, we demonstrated that deficits in spatial navigation could still be induced in adult rats that received both bicuculline treatment in the VN and oral administration of fluoxetine from P21 onwards. This implies that fluoxetine restores the plasticity observed in critical period during which bicuculline induces deficits in spatial navigation. With western blot analysis, we found that oral administration of fluoxetine during P21–28 significantly reduced protein expression of potassium-chloride co-transporter (KCC2) in the VN. Since KCC2 is responsible for the extrusion of chloride ions, lower level of KCC2 expression indicates less chloride ions flowing through GABAAR, causing a reduction in the impact of inhibitory GABAergic transmission. The latter is corroborated with the observation that the proportion of VN neurons exhibiting GABAAR-mediated long-term depression (LTD) was significantly increased from 34.6% in controls to 50% in P28 rats pre-treated with fluoxetine during P21–28. These results imply that fluoxetine induces a reduction in GABAergic transmission, thus contributing to the restoration of the plasticity observed in critical period. [Supported by HKU 761812M].-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1471-4159-
dc.relation.ispartofJournal of Neurochemistry-
dc.rightsPreprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article]. Authors are not required to remove preprints posted prior to acceptance of the submitted version. Postprint This is the accepted version of the following article: [full citation], which has been published in final form at [Link to final article].-
dc.titleFluoxetine induces restoration of plasticity in the adult vestibular system-
dc.typeConference_Paper-
dc.identifier.emailMa, CW: cwma2010@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.authorityChan, YS=rp00318-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/jnc.13188-
dc.identifier.hkuros267156-
dc.identifier.volume134-
dc.identifier.issuesuppl. S1-
dc.identifier.spage158, abstract no. MTU07-15-
dc.identifier.epage158, abstract no. MTU07-15-
dc.publisher.placeUnited Kingdom-

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