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Article: High-Density PEO-b-DNA Brushes on Polymer Particles for Colloidal Superstructures

TitleHigh-Density PEO-b-DNA Brushes on Polymer Particles for Colloidal Superstructures
Authors
Issue Date2015
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/cm
Citation
Chemistry of Materials, 2015, v. 27 n. 24, p. 8337-8344 How to Cite?
AbstractWe demonstrate a method to create high-density DNA coatings on colloidal particles that can be used for DNA-mediated self-assembly of single- and multiple-component colloidal crystals. First, we modify an amphiphilic diblock copolymer consisting of a hydrophobic polystyrene (PS) block and a hydrophilic poly(ethylene oxide) (PEO) block with azide functional groups at the end (poly(ethylene oxide)-N3). Then, we introduce the diblock copolymers into an aqueous suspension of colloidal polymer particles swollen with a solvent. The hydrophobic PS anchoring block is incorporated into the swollen polymer spheres and physically trapped when the solvent is removed, resulting in a dense PEO polymer brush with azide functional end groups. Finally, single-stranded DNA strands with sticky ends are attached to the azide groups using strain-promoted azide-alkyne cycloaddition (SPAAC, a copper-free click chemistry). This procedure results in a high areal coverage of up to 225-000 DNA strands on 1-μm-diameter particles. The ssDNA-coated particles with sticky ends can readily form either face-centered-cubic (fcc) or cesium chloride (CsCl) crystal structures when annealed just below the melting temperature of the DNA-coated particles.
Persistent Identifierhttp://hdl.handle.net/10722/231072
ISSN
2015 Impact Factor: 9.407
2015 SCImago Journal Rankings: 4.232

 

DC FieldValueLanguage
dc.contributor.authorOh, JS-
dc.contributor.authorWang, Y-
dc.contributor.authorPine, DJ-
dc.contributor.authorYi, GR-
dc.date.accessioned2016-09-02T01:39:27Z-
dc.date.available2016-09-02T01:39:27Z-
dc.date.issued2015-
dc.identifier.citationChemistry of Materials, 2015, v. 27 n. 24, p. 8337-8344-
dc.identifier.issn0897-4756-
dc.identifier.urihttp://hdl.handle.net/10722/231072-
dc.description.abstractWe demonstrate a method to create high-density DNA coatings on colloidal particles that can be used for DNA-mediated self-assembly of single- and multiple-component colloidal crystals. First, we modify an amphiphilic diblock copolymer consisting of a hydrophobic polystyrene (PS) block and a hydrophilic poly(ethylene oxide) (PEO) block with azide functional groups at the end (poly(ethylene oxide)-N3). Then, we introduce the diblock copolymers into an aqueous suspension of colloidal polymer particles swollen with a solvent. The hydrophobic PS anchoring block is incorporated into the swollen polymer spheres and physically trapped when the solvent is removed, resulting in a dense PEO polymer brush with azide functional end groups. Finally, single-stranded DNA strands with sticky ends are attached to the azide groups using strain-promoted azide-alkyne cycloaddition (SPAAC, a copper-free click chemistry). This procedure results in a high areal coverage of up to 225-000 DNA strands on 1-μm-diameter particles. The ssDNA-coated particles with sticky ends can readily form either face-centered-cubic (fcc) or cesium chloride (CsCl) crystal structures when annealed just below the melting temperature of the DNA-coated particles.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/cm-
dc.relation.ispartofChemistry of Materials-
dc.titleHigh-Density PEO-b-DNA Brushes on Polymer Particles for Colloidal Superstructures-
dc.typeArticle-
dc.identifier.emailWang, Y: wanglab@hku.hk-
dc.identifier.authorityWang, Y=rp02191-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.chemmater.5b03683-
dc.identifier.scopuseid_2-s2.0-84951767605-
dc.identifier.volume27-
dc.identifier.issue24-
dc.identifier.spage8337-
dc.identifier.epage8344-
dc.publisher.placeUnited States-

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