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Article: Impact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial

TitleImpact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial
Authors
KeywordsExploratory analysis
Treatment
Human
Generalized aggressive periodontitis
Antimicrobials
Aggregatibacter actinomycetemcomitans
Issue Date2014
Citation
Journal of Clinical Periodontology, 2014, v. 41, n. 11, p. 1080-1089 How to Cite?
Abstract© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis. However, secondary exploratory subgroup analyses showed improved clinical outcomes in subjects harbouring
Persistent Identifierhttp://hdl.handle.net/10722/231032
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGuerrero, Adrián-
dc.contributor.authorNibali, Luigi-
dc.contributor.authorLambertenghi, Roberta-
dc.contributor.authorReady, Derren-
dc.contributor.authorSuvan, Jean-
dc.contributor.authorGriffiths, Gareth S.-
dc.contributor.authorWilson, Michael-
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:07:26Z-
dc.date.available2016-09-01T06:07:26Z-
dc.date.issued2014-
dc.identifier.citationJournal of Clinical Periodontology, 2014, v. 41, n. 11, p. 1080-1089-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/231032-
dc.description.abstract© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.Aim: To explore whether subjects harbouring A. actinomycetemcomitans, P. gingivalis or T. forsythia at baseline showed increased clinical benefits with the adjunctive use of systemic amoxicillin and metronidazole (AMX-MET) during non-surgical treatment of generalized aggressive periodontitis (GAgP). Material and Methods: Forty one subjects were included in this 6-month randomized placebo-controlled clinical trial using a 7-day course of systemic AMX-MET or placebo as adjuncts to non-surgical periodontal therapy. Clinical and microbiological parameters were collected at baseline, 2 and 6 months after treatment. Microbiological cultures were processed for pooled subgingival samples and identities of isolates were determined by PCR for A. actinomycetemcomitans, P. gingivalis and T. forsythia Results: At 6 months, the test treatment resulted in significant additional improvements in the primary outcome variable compared to placebo, and the effect of the adjunctive antimicrobials was not modified by the baseline microbiological status in the primary analysis. However, secondary exploratory subgroup analyses showed improved clinical outcomes in subjects harbouring-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectExploratory analysis-
dc.subjectTreatment-
dc.subjectHuman-
dc.subjectGeneralized aggressive periodontitis-
dc.subjectAntimicrobials-
dc.subjectAggregatibacter actinomycetemcomitans-
dc.titleImpact of baseline microbiological status on clinical outcomes in generalized aggressive periodontitis patients treated with or without adjunctive amoxicillin and metronidazole: An exploratory analysis from a randomized controlled clinical trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jcpe.12299-
dc.identifier.pmid25139116-
dc.identifier.scopuseid_2-s2.0-84964253493-
dc.identifier.volume41-
dc.identifier.issue11-
dc.identifier.spage1080-
dc.identifier.epage1089-
dc.identifier.eissn1600-051X-

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