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Article: Amoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial

TitleAmoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial
Authors
Keywordshuman
generalized aggressive periodontitis
randomized controlled clinical trial
treatment
antibiotics
Issue Date2011
Citation
Journal of Clinical Periodontology, 2011, v. 38, n. 1, p. 43-49 How to Cite?
AbstractBackground: Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non-surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re-treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group. Methods: Thirty-eight of 41 subjects, from the initial 6-month trial, completed the second phase, re-treatment of sites with remaining pockets 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline). Results: Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re-treatment. In deep pockets (7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4-6 mm) it was 0.4 mm (p=0.036). For pockets converting from 5 to 4 mm, this was 83% compared with 67% (p=0.041) and pockets converting from 4 to 3 mm was 63% compared with 49% (p=0.297). Conclusions: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re-treatment. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/230860
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGriffiths, Gareth S.-
dc.contributor.authorAyob, Rasidah-
dc.contributor.authorGuerrero, Adrian-
dc.contributor.authorNibali, Luigi-
dc.contributor.authorSuvan, Jean-
dc.contributor.authorMoles, David R.-
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:06:58Z-
dc.date.available2016-09-01T06:06:58Z-
dc.date.issued2011-
dc.identifier.citationJournal of Clinical Periodontology, 2011, v. 38, n. 1, p. 43-49-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230860-
dc.description.abstractBackground: Previously, we showed that systemic metronidazole and amoxicillin significantly improved the outcomes of non-surgical debridement in generalized aggressive periodontitis patients. This study aimed to observe whether re-treatment with adjunctive antimicrobials would give the placebo group benefits comparable with the test group. Methods: Thirty-eight of 41 subjects, from the initial 6-month trial, completed the second phase, re-treatment of sites with remaining pockets 5 mm. Subjects on placebo in phase one, received adjunctive antibiotics for 7 days. Clinical parameters were collected at 2 months posttreatment (8 months from baseline). Results: Patients who received antibiotics at initial therapy, showed statistically significant improvement in pocket depth reduction and in the % of sites improving above clinically relevant thresholds, compared with patients who received antibiotics at re-treatment. In deep pockets (7 mm), the mean difference was 0.9 mm (p=0.003) and in moderate pockets (4-6 mm) it was 0.4 mm (p=0.036). For pockets converting from 5 to 4 mm, this was 83% compared with 67% (p=0.041) and pockets converting from 4 to 3 mm was 63% compared with 49% (p=0.297). Conclusions: At 8 months, patients who had antibiotics at initial therapy showed statistically significant benefits compared with those who had antibiotics at re-treatment. © 2010 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjecthuman-
dc.subjectgeneralized aggressive periodontitis-
dc.subjectrandomized controlled clinical trial-
dc.subjecttreatment-
dc.subjectantibiotics-
dc.titleAmoxicillin and metronidazole as an adjunctive treatment in generalized aggressive periodontitis at initial therapy or re-treatment: A randomized controlled clinical trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2010.01632.x-
dc.identifier.pmid21062335-
dc.identifier.scopuseid_2-s2.0-78650383157-
dc.identifier.volume38-
dc.identifier.issue1-
dc.identifier.spage43-
dc.identifier.epage49-
dc.identifier.eissn1600-051X-

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