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Article: Systemic inflammation following non-surgical and surgical periodontal therapy

TitleSystemic inflammation following non-surgical and surgical periodontal therapy
Authors
Keywordscystatin C
C reactive protein
periodontal disease
periodontal surgery
systemic inflammation
Issue Date2010
Citation
Journal of Clinical Periodontology, 2010, v. 37, n. 9, p. 848-854 How to Cite?
AbstractAim: To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non-surgical treatment of chronic periodontitis (CP). Material and Methods: Fourteen CP cases received full-mouth non-surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time-points after treatment. Blood markers of systemic inflammationcoagulation including leucocyte counts, C-reactive protein (CRP), serum amyloid-A (SAA) and D-dimers and renal function (cystatin C) were determined using high-sensitivity assays. Results: Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non-surgical therapy (p<0.001). Surgical therapy led to an additional reduction of periodontal pockets (p<0.01). Marked increases in the serum levels of CRP and SAA were noted 24 h after non-surgical therapy (p<0.01) and periodontal surgeries (p<0.05). D-dimer levels increased drastically 24 h after non-surgical therapy (p<0.05). The drastic increase of CRP after non-surgical therapy was greater than both the surgical therapy sessions (p<0.05). Conclusions: Patients undergoing periodontal treatment experience perturbations of systemic inflammation of a greater magnitude after non-surgical than surgical periodontal therapy. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/230855
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGraziani, Filippo-
dc.contributor.authorCei, Silvia-
dc.contributor.authorTonetti, Maurizio-
dc.contributor.authorPaolantonio, Michele-
dc.contributor.authorSerio, Rossella-
dc.contributor.authorSammartino, Gilberto-
dc.contributor.authorGabriele, Mario-
dc.contributor.authorD'Aiuto, Francesco-
dc.date.accessioned2016-09-01T06:06:58Z-
dc.date.available2016-09-01T06:06:58Z-
dc.date.issued2010-
dc.identifier.citationJournal of Clinical Periodontology, 2010, v. 37, n. 9, p. 848-854-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230855-
dc.description.abstractAim: To describe the kinetics of serum inflammatory markers after a course of treatment comprising surgical and non-surgical treatment of chronic periodontitis (CP). Material and Methods: Fourteen CP cases received full-mouth non-surgical treatment and, after 6 months, at least two surgical sessions. Blood samples were collected at various time-points after treatment. Blood markers of systemic inflammationcoagulation including leucocyte counts, C-reactive protein (CRP), serum amyloid-A (SAA) and D-dimers and renal function (cystatin C) were determined using high-sensitivity assays. Results: Periodontal treatment resulted in substantial reductions of the number of pockets, gingival bleeding and plaque at 3 and 6 months after non-surgical therapy (p<0.001). Surgical therapy led to an additional reduction of periodontal pockets (p<0.01). Marked increases in the serum levels of CRP and SAA were noted 24 h after non-surgical therapy (p<0.01) and periodontal surgeries (p<0.05). D-dimer levels increased drastically 24 h after non-surgical therapy (p<0.05). The drastic increase of CRP after non-surgical therapy was greater than both the surgical therapy sessions (p<0.05). Conclusions: Patients undergoing periodontal treatment experience perturbations of systemic inflammation of a greater magnitude after non-surgical than surgical periodontal therapy. © 2010 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectcystatin C-
dc.subjectC reactive protein-
dc.subjectperiodontal disease-
dc.subjectperiodontal surgery-
dc.subjectsystemic inflammation-
dc.titleSystemic inflammation following non-surgical and surgical periodontal therapy-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2010.01585.x-
dc.identifier.pmid20546085-
dc.identifier.scopuseid_2-s2.0-77955750544-
dc.identifier.volume37-
dc.identifier.issue9-
dc.identifier.spage848-
dc.identifier.epage854-
dc.identifier.eissn1600-051X-

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