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Article: Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: An exploratory trial

TitleEffects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: An exploratory trial
Authors
KeywordsPeriodontal disease
Inflammation
C reactive protein
Cystatin C
Issue Date2010
Citation
Journal of Clinical Periodontology, 2010, v. 37, n. 7, p. 638-643 How to Cite?
AbstractObjective: To determine whether non-surgical periodontal treatment (PT) would exert, in subjects with generalized chronic periodontitis (GCP), some beneficial effect on renal function as indicated by surrogate measures of the glomerular filtration rate (GFR). Material and Methods: Twenty GCP systemically healthy subjects were treated with PT. Serum samples were collected at baseline and 1 day, 7, 30, 90 and 180 days after treatment. GFR was evaluated using cystatin C, a serum marker and modification of diet in renal disease (MDRD), an equation involving creatinine, urea and albumin. Serum markers of systemic inflammation such as C-reactive protein (CRP), D-dimer, serum amyloid A (SAA) and fibrinogen were also assessed. Results: The cystatin C level decreased significantly from baseline to the end of the trial (p<0.01). Conversely, MDRD did not vary. A significant inflammatory reaction was produced by PT in the short term. Greater increases were noted for CRP and SAA within 24 h (p<0.001 versus baseline), while d-dimer (p<0.05) and fibrinogen (p<0.01) showed mild variations. The values of inflammatory markers were normalized after 30 days. Conclusions: GFR, as assessed by cystatin C levels, may be positively affected by PT. Because of the exploratory nature of this trial, further research is needed to investigate this preliminary finding. © 2010 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/230852
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGraziani, Filippo-
dc.contributor.authorCei, Silvia-
dc.contributor.authorLa Ferla, Fabio-
dc.contributor.authorVano, Michele-
dc.contributor.authorGabriele, Mario-
dc.contributor.authorTonetti, Maurizio-
dc.date.accessioned2016-09-01T06:06:57Z-
dc.date.available2016-09-01T06:06:57Z-
dc.date.issued2010-
dc.identifier.citationJournal of Clinical Periodontology, 2010, v. 37, n. 7, p. 638-643-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230852-
dc.description.abstractObjective: To determine whether non-surgical periodontal treatment (PT) would exert, in subjects with generalized chronic periodontitis (GCP), some beneficial effect on renal function as indicated by surrogate measures of the glomerular filtration rate (GFR). Material and Methods: Twenty GCP systemically healthy subjects were treated with PT. Serum samples were collected at baseline and 1 day, 7, 30, 90 and 180 days after treatment. GFR was evaluated using cystatin C, a serum marker and modification of diet in renal disease (MDRD), an equation involving creatinine, urea and albumin. Serum markers of systemic inflammation such as C-reactive protein (CRP), D-dimer, serum amyloid A (SAA) and fibrinogen were also assessed. Results: The cystatin C level decreased significantly from baseline to the end of the trial (p<0.01). Conversely, MDRD did not vary. A significant inflammatory reaction was produced by PT in the short term. Greater increases were noted for CRP and SAA within 24 h (p<0.001 versus baseline), while d-dimer (p<0.05) and fibrinogen (p<0.01) showed mild variations. The values of inflammatory markers were normalized after 30 days. Conclusions: GFR, as assessed by cystatin C levels, may be positively affected by PT. Because of the exploratory nature of this trial, further research is needed to investigate this preliminary finding. © 2010 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectPeriodontal disease-
dc.subjectInflammation-
dc.subjectC reactive protein-
dc.subjectCystatin C-
dc.titleEffects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: An exploratory trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2010.01578.x-
dc.identifier.pmid20500539-
dc.identifier.scopuseid_2-s2.0-77953580928-
dc.identifier.volume37-
dc.identifier.issue7-
dc.identifier.spage638-
dc.identifier.epage643-
dc.identifier.eissn1600-051X-

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