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Article: Periodontitis and risk for atherosclerosis: An update on intervention trials

TitlePeriodontitis and risk for atherosclerosis: An update on intervention trials
Authors
KeywordsCausality
Review
Periodontitis
Controlled clinical trials
Atherosclerosis
Issue Date2009
Citation
Journal of Clinical Periodontology, 2009, v. 36, n. SUPPL. 10, p. 15-19 How to Cite?
AbstractAims: Periodontitis has been associated with an increased risk of cardiovascular events. The nature of the association is unclear because both periodontitis and cardiovascular disease (CVD) share a host of risk factors. Intervention trials are critical to explore the relationship. If the association were causal, successful periodontal therapy will lead to an attenuation of the effect - CVD. Material and Methods: The paper reviewed the design and the results of intervention trials aimed at improving systemic inflammation, endothelial dysfunction, carotid atherosclerosis and cardiovascular events. Results: Early systematic reviews and a definitive controlled clinical trial indicate that intensive periodontal therapy results in a decrease in systemic inflammation and an improvement of endothelial dysfunction in systemically healthy subjects. A pilot trial has indicated the feasibility to assess the impact of periodontal therapy on carotid atherosclerosis in a primary cardiac prevention design. Conclusions: Efforts to test causality in the relationship between periodontitis and CVD are ongoing. Evidence to date is consistent with the notion that severe generalized periodontitis causes systemic inflammation and endothelial dysfunction. Periodontitis has effects that go beyond the oral cavity and its treatment and prevention may contribute to the prevention of atherosclerosis. © 2009 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/230834
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:06:55Z-
dc.date.available2016-09-01T06:06:55Z-
dc.date.issued2009-
dc.identifier.citationJournal of Clinical Periodontology, 2009, v. 36, n. SUPPL. 10, p. 15-19-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230834-
dc.description.abstractAims: Periodontitis has been associated with an increased risk of cardiovascular events. The nature of the association is unclear because both periodontitis and cardiovascular disease (CVD) share a host of risk factors. Intervention trials are critical to explore the relationship. If the association were causal, successful periodontal therapy will lead to an attenuation of the effect - CVD. Material and Methods: The paper reviewed the design and the results of intervention trials aimed at improving systemic inflammation, endothelial dysfunction, carotid atherosclerosis and cardiovascular events. Results: Early systematic reviews and a definitive controlled clinical trial indicate that intensive periodontal therapy results in a decrease in systemic inflammation and an improvement of endothelial dysfunction in systemically healthy subjects. A pilot trial has indicated the feasibility to assess the impact of periodontal therapy on carotid atherosclerosis in a primary cardiac prevention design. Conclusions: Efforts to test causality in the relationship between periodontitis and CVD are ongoing. Evidence to date is consistent with the notion that severe generalized periodontitis causes systemic inflammation and endothelial dysfunction. Periodontitis has effects that go beyond the oral cavity and its treatment and prevention may contribute to the prevention of atherosclerosis. © 2009 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectCausality-
dc.subjectReview-
dc.subjectPeriodontitis-
dc.subjectControlled clinical trials-
dc.subjectAtherosclerosis-
dc.titlePeriodontitis and risk for atherosclerosis: An update on intervention trials-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2009.01417.x-
dc.identifier.pmid19432627-
dc.identifier.scopuseid_2-s2.0-65649150694-
dc.identifier.volume36-
dc.identifier.issueSUPPL. 10-
dc.identifier.spage15-
dc.identifier.epage19-
dc.identifier.eissn1600-051X-

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