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Article: Gene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections

TitleGene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections
Authors
KeywordsInflammation
Polymorphisms
Periodontitis
C-reactive protein
Interleukin-6
Issue Date2004
Citation
Cytokine, 2004, v. 28, n. 1, p. 29-34 How to Cite?
AbstractThe inflammatory response to chronic infections such as periodontitis may be central to the systemic implications of these diseases. This study examined the possible association between specific gene polymorphisms and the systemic inflammatory response in individuals suffering from severe generalized periodontitis. Ninety-four subjects with periodontitis were genotyped for polymorphisms in IL-1A (-889), IL-1B (-511, +3954), TNF-A (-308), IL-6 (-174) and TLR4 (-299, -399) genes. We found that the genotypes for IL-1A or IL-6 are associated with higher levels of serum IL-6 (P < 0.03) and serum CRP (P < 0.05), similarly the TNF-A genotype is associated with higher levels of serum IL-6 (P < 0.05) after correction for age, body mass index, gender, ethnicity and cigarette smoking. Systemic inflammatory responses are higher in severe periodontitis patients carrying rare alleles for functional inflammatory gene polymorphisms. These results suggest that cytokine genotypes are important determinants of the systemic inflammatory response in subjects with periodontitis. Genetic polymorphism therefore, may in part explain the reported association between periodontitis and systemic disease. © 2004 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/230810
ISSN
2015 Impact Factor: 2.94
2015 SCImago Journal Rankings: 1.294

 

DC FieldValueLanguage
dc.contributor.authorD'Aiuto, F.-
dc.contributor.authorParkar, M.-
dc.contributor.authorBrett, P. M.-
dc.contributor.authorReady, D.-
dc.contributor.authorTonetti, M. S.-
dc.date.accessioned2016-09-01T06:06:51Z-
dc.date.available2016-09-01T06:06:51Z-
dc.date.issued2004-
dc.identifier.citationCytokine, 2004, v. 28, n. 1, p. 29-34-
dc.identifier.issn1043-4666-
dc.identifier.urihttp://hdl.handle.net/10722/230810-
dc.description.abstractThe inflammatory response to chronic infections such as periodontitis may be central to the systemic implications of these diseases. This study examined the possible association between specific gene polymorphisms and the systemic inflammatory response in individuals suffering from severe generalized periodontitis. Ninety-four subjects with periodontitis were genotyped for polymorphisms in IL-1A (-889), IL-1B (-511, +3954), TNF-A (-308), IL-6 (-174) and TLR4 (-299, -399) genes. We found that the genotypes for IL-1A or IL-6 are associated with higher levels of serum IL-6 (P < 0.03) and serum CRP (P < 0.05), similarly the TNF-A genotype is associated with higher levels of serum IL-6 (P < 0.05) after correction for age, body mass index, gender, ethnicity and cigarette smoking. Systemic inflammatory responses are higher in severe periodontitis patients carrying rare alleles for functional inflammatory gene polymorphisms. These results suggest that cytokine genotypes are important determinants of the systemic inflammatory response in subjects with periodontitis. Genetic polymorphism therefore, may in part explain the reported association between periodontitis and systemic disease. © 2004 Elsevier Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofCytokine-
dc.subjectInflammation-
dc.subjectPolymorphisms-
dc.subjectPeriodontitis-
dc.subjectC-reactive protein-
dc.subjectInterleukin-6-
dc.titleGene polymorphisms in pro-inflammatory cytokines are associated with systemic inflammation in patients with severe periodontal infections-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cyto.2004.06.005-
dc.identifier.pmid15341923-
dc.identifier.scopuseid_2-s2.0-4444258811-
dc.identifier.volume28-
dc.identifier.issue1-
dc.identifier.spage29-
dc.identifier.epage34-

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