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Article: Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches (Taeniopygia guttata) selected for acute high corticosterone response to stress

TitleSpatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches (Taeniopygia guttata) selected for acute high corticosterone response to stress
Authors
KeywordsGlucocorticoid receptor
Mineralocorticoid receptor
Spatial learning
Zebra finch
Artificial selection
Corticosterone
Issue Date2007
Citation
Proceedings of the Royal Society B: Biological Sciences, 2007, v. 274, n. 1607, p. 239-245 How to Cite?
AbstractIn mammals, stress hormones have profound influences on spatial learning and memory. Here, we investigated whether glucocorticoids influence cognitive abilities in birds by testing a line of zebra finches selectively bred to respond to an acute stressor with high plasma corticosterone (CORT) levels. Cognitive performance was assessed by spatial and visual one-trial associative memory tasks. Task performance in the high CORT birds was compared with that of the random-bred birds from a control breeding line. The birds selected for high CORT in response to an acute stressor performed less well than the controls in the spatial task, but there were no significant differences between the lines in performance during the visual task. The birds from the two lines did not differ in their plasma CORT levels immediately after the performance of the memory tasks; nevertheless, there were significant differences in peak plasma CORT between the lines. The high CORT birds also had significantly lower mineralocorticoid receptor mRNA expression in the hippocampus than the control birds. There was no measurable difference between the lines in glucocorticoid receptor mRNA density in either the hippocampus or the paraventricular nucleus. Together, these findings provide evidence to suggest that stress hormones have important regulatory roles in avian spatial cognition. © 2006 The Royal Society.
Persistent Identifierhttp://hdl.handle.net/10722/230786
ISSN
2015 Impact Factor: 4.823
2015 SCImago Journal Rankings: 2.375

 

DC FieldValueLanguage
dc.contributor.authorHodgson, Zoë G.-
dc.contributor.authorMeddle, Simone L.-
dc.contributor.authorRoberts, Mark L.-
dc.contributor.authorBuchanan, Katherine L.-
dc.contributor.authorEvans, Matthew R.-
dc.contributor.authorMetzdorf, Reinhold-
dc.contributor.authorGahr, Manfred-
dc.contributor.authorHealy, Susan D.-
dc.date.accessioned2016-09-01T06:06:48Z-
dc.date.available2016-09-01T06:06:48Z-
dc.date.issued2007-
dc.identifier.citationProceedings of the Royal Society B: Biological Sciences, 2007, v. 274, n. 1607, p. 239-245-
dc.identifier.issn0962-8452-
dc.identifier.urihttp://hdl.handle.net/10722/230786-
dc.description.abstractIn mammals, stress hormones have profound influences on spatial learning and memory. Here, we investigated whether glucocorticoids influence cognitive abilities in birds by testing a line of zebra finches selectively bred to respond to an acute stressor with high plasma corticosterone (CORT) levels. Cognitive performance was assessed by spatial and visual one-trial associative memory tasks. Task performance in the high CORT birds was compared with that of the random-bred birds from a control breeding line. The birds selected for high CORT in response to an acute stressor performed less well than the controls in the spatial task, but there were no significant differences between the lines in performance during the visual task. The birds from the two lines did not differ in their plasma CORT levels immediately after the performance of the memory tasks; nevertheless, there were significant differences in peak plasma CORT between the lines. The high CORT birds also had significantly lower mineralocorticoid receptor mRNA expression in the hippocampus than the control birds. There was no measurable difference between the lines in glucocorticoid receptor mRNA density in either the hippocampus or the paraventricular nucleus. Together, these findings provide evidence to suggest that stress hormones have important regulatory roles in avian spatial cognition. © 2006 The Royal Society.-
dc.languageeng-
dc.relation.ispartofProceedings of the Royal Society B: Biological Sciences-
dc.subjectGlucocorticoid receptor-
dc.subjectMineralocorticoid receptor-
dc.subjectSpatial learning-
dc.subjectZebra finch-
dc.subjectArtificial selection-
dc.subjectCorticosterone-
dc.titleSpatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches (Taeniopygia guttata) selected for acute high corticosterone response to stress-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1098/rspb.2006.3704-
dc.identifier.scopuseid_2-s2.0-34447306665-
dc.identifier.volume274-
dc.identifier.issue1607-
dc.identifier.spage239-
dc.identifier.epage245-
dc.identifier.eissn1471-2970-

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