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Article: Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial

TitleAdjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial
Authors
KeywordsHuman
Generalized aggressive periodontitis
Randomized- controlled clinical trial
Antibiotics
Treatment
Issue Date2005
Citation
Journal of Clinical Periodontology, 2005, v. 32, n. 10, p. 1096-1107 How to Cite?
AbstractBackground: The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP). Methods: Forty-one systemically healthy subjects with GAP were included in this 6-month double-blind, placebo-controlled, randomized clinical trial. Patients received a course of full-mouth non-surgical periodontal treatment delivered over a 24 h period using machine-driven and hand instruments. Test subjects received an adjunctive course of systemic antibiotic consisting of 500 mg amoxicillin and 500 mg metronidazole three times a day for 7 days. Clinical parameters were collected at baseline, and at 2 and 6 months post-treatment. Results: In both the test and the placebo groups, all clinical parameters improved at 2 and 6 months. In deep pockets (≥7 mm), the test treatment resulted in an additional 1.4 mm (95% confidence interval 0.8, 2.0 mm) in full-mouth probing pocket depth (PPD) reduction and 1 mm (0.7, 1.3 mm) of life cumulative attachment loss (LCAL) gain at 6 months. In moderate pockets (4-6 mm), the adjunctive benefit was smaller in magnitude: PPD reduction was 0.4 mm (0.1, 0.7 mm) and LCAL gain was 0.5 mm (0.2, 0.8 mm). In addition, the 6-month data showed LCAL gains ≥2 mm at 25% of sites in test patients compared with 16% in placebo (p = 0.028). Similarly, PPD reductions of 2 mm or more were observed in 30% of sites in test and 21% of sites in placebo patients. Seventy-four percent of pockets with PPD ≥5 mm at baseline were 4 mm or shallower at 6 months in the test group. This compared with 54% in the placebo group (p = 0.008). Disease progression at 6 months was observed at 1.5% of test and 3.3% of sites in test and placebo, respectively (p = 0.072). Conclusions: These data indicate that a 7-day adjunctive course of systemic metronidazole and amoxicillin significantly improved the short-term clinical outcomes of full-mouth non-surgical periodontal debridement in subjects with GAP. © Blackwell Munksgaard 2005.
Persistent Identifierhttp://hdl.handle.net/10722/230747
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGuerrero, Adrian-
dc.contributor.authorGriffiths, Gareth S.-
dc.contributor.authorNibali, Luigi-
dc.contributor.authorSuvan, Jean-
dc.contributor.authorMoles, David R.-
dc.contributor.authorLaurell, Lars-
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:06:42Z-
dc.date.available2016-09-01T06:06:42Z-
dc.date.issued2005-
dc.identifier.citationJournal of Clinical Periodontology, 2005, v. 32, n. 10, p. 1096-1107-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230747-
dc.description.abstractBackground: The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP). Methods: Forty-one systemically healthy subjects with GAP were included in this 6-month double-blind, placebo-controlled, randomized clinical trial. Patients received a course of full-mouth non-surgical periodontal treatment delivered over a 24 h period using machine-driven and hand instruments. Test subjects received an adjunctive course of systemic antibiotic consisting of 500 mg amoxicillin and 500 mg metronidazole three times a day for 7 days. Clinical parameters were collected at baseline, and at 2 and 6 months post-treatment. Results: In both the test and the placebo groups, all clinical parameters improved at 2 and 6 months. In deep pockets (≥7 mm), the test treatment resulted in an additional 1.4 mm (95% confidence interval 0.8, 2.0 mm) in full-mouth probing pocket depth (PPD) reduction and 1 mm (0.7, 1.3 mm) of life cumulative attachment loss (LCAL) gain at 6 months. In moderate pockets (4-6 mm), the adjunctive benefit was smaller in magnitude: PPD reduction was 0.4 mm (0.1, 0.7 mm) and LCAL gain was 0.5 mm (0.2, 0.8 mm). In addition, the 6-month data showed LCAL gains ≥2 mm at 25% of sites in test patients compared with 16% in placebo (p = 0.028). Similarly, PPD reductions of 2 mm or more were observed in 30% of sites in test and 21% of sites in placebo patients. Seventy-four percent of pockets with PPD ≥5 mm at baseline were 4 mm or shallower at 6 months in the test group. This compared with 54% in the placebo group (p = 0.008). Disease progression at 6 months was observed at 1.5% of test and 3.3% of sites in test and placebo, respectively (p = 0.072). Conclusions: These data indicate that a 7-day adjunctive course of systemic metronidazole and amoxicillin significantly improved the short-term clinical outcomes of full-mouth non-surgical periodontal debridement in subjects with GAP. © Blackwell Munksgaard 2005.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectHuman-
dc.subjectGeneralized aggressive periodontitis-
dc.subjectRandomized- controlled clinical trial-
dc.subjectAntibiotics-
dc.subjectTreatment-
dc.titleAdjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: A randomized placebo-controlled clinical trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2005.00814.x-
dc.identifier.pmid16174275-
dc.identifier.scopuseid_2-s2.0-25844497516-
dc.identifier.volume32-
dc.identifier.issue10-
dc.identifier.spage1096-
dc.identifier.epage1107-

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