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Article: Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: A model for tissue regeneration

TitleExpression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: A model for tissue regeneration
Authors
KeywordsRegeneration
Gene arrays
Enamel matrix
In vitro
Periodontium
Issue Date2002
Citation
Journal of Dental Research, 2002, v. 81, n. 11, p. 776-783 How to Cite?
AbstractSeveral studies have examined the role of enamel matrix proteins in root formation and periodontal regeneration, although most of these have focused on a few specific genes which had previously been implicated. However, recent advances in expressional profiling have made it possible to examine the range of genetic responses involved in these processes. In the present experiments, we have therefore utilized this technique to determine the effects of enamel matrix proteins on the gene activities of periodontal ligament cells in vitro. Such cells were found to have an elevated level of RNA synthesis compared with control cells. Moreover, hybridization of the cDNA prepared from this RNA to gene array filters showed that there was differential expression of 121 genes, most of which had not previously been associated with periodontal regeneration. Some of these selective changes in gene activity might thus reflect the fundamental events that underlie periodontal development.
Persistent Identifierhttp://hdl.handle.net/10722/230718
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorBrett, P. M.-
dc.contributor.authorParkar, M.-
dc.contributor.authorOlsen, I.-
dc.contributor.authorTonetti, M.-
dc.date.accessioned2016-09-01T06:06:38Z-
dc.date.available2016-09-01T06:06:38Z-
dc.date.issued2002-
dc.identifier.citationJournal of Dental Research, 2002, v. 81, n. 11, p. 776-783-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/230718-
dc.description.abstractSeveral studies have examined the role of enamel matrix proteins in root formation and periodontal regeneration, although most of these have focused on a few specific genes which had previously been implicated. However, recent advances in expressional profiling have made it possible to examine the range of genetic responses involved in these processes. In the present experiments, we have therefore utilized this technique to determine the effects of enamel matrix proteins on the gene activities of periodontal ligament cells in vitro. Such cells were found to have an elevated level of RNA synthesis compared with control cells. Moreover, hybridization of the cDNA prepared from this RNA to gene array filters showed that there was differential expression of 121 genes, most of which had not previously been associated with periodontal regeneration. Some of these selective changes in gene activity might thus reflect the fundamental events that underlie periodontal development.-
dc.languageeng-
dc.relation.ispartofJournal of Dental Research-
dc.subjectRegeneration-
dc.subjectGene arrays-
dc.subjectEnamel matrix-
dc.subjectIn vitro-
dc.subjectPeriodontium-
dc.titleExpression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: A model for tissue regeneration-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid12407094-
dc.identifier.scopuseid_2-s2.0-0036828071-
dc.identifier.volume81-
dc.identifier.issue11-
dc.identifier.spage776-
dc.identifier.epage783-

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