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- Publisher Website: 10.1016/S0168-3659(00)00233-9
- Scopus: eid_2-s2.0-0034738789
- PMID: 10884580
- WOS: WOS:000088390100007
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Article: Sustained release of silver from periodontal wafers for treatment of periodontitis
Title | Sustained release of silver from periodontal wafers for treatment of periodontitis |
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Authors | |
Keywords | Periodontal wafers Staining Antimicrobial agent Silver nitrate |
Issue Date | 2000 |
Citation | Journal of Controlled Release, 2000, v. 68, n. 1, p. 63-72 How to Cite? |
Abstract | Periodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. Copyright (C) 2000 Elsevier Science B.V. |
Persistent Identifier | http://hdl.handle.net/10722/230708 |
ISSN | 2021 Impact Factor: 11.467 2020 SCImago Journal Rankings: 2.119 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Bromberg, Lev E. | - |
dc.contributor.author | Braman, Virginia M. | - |
dc.contributor.author | Rothstein, David M. | - |
dc.contributor.author | Spacciapoli, Peter | - |
dc.contributor.author | O'Connor, Sandra M. | - |
dc.contributor.author | Nelson, Eric J. | - |
dc.contributor.author | Buxton, Debra K. | - |
dc.contributor.author | Tonetti, Maurizio S. | - |
dc.contributor.author | Friden, Phillip M. | - |
dc.date.accessioned | 2016-09-01T06:06:36Z | - |
dc.date.available | 2016-09-01T06:06:36Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Journal of Controlled Release, 2000, v. 68, n. 1, p. 63-72 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230708 | - |
dc.description.abstract | Periodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. Copyright (C) 2000 Elsevier Science B.V. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Controlled Release | - |
dc.subject | Periodontal wafers | - |
dc.subject | Staining | - |
dc.subject | Antimicrobial agent | - |
dc.subject | Silver nitrate | - |
dc.title | Sustained release of silver from periodontal wafers for treatment of periodontitis | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0168-3659(00)00233-9 | - |
dc.identifier.pmid | 10884580 | - |
dc.identifier.scopus | eid_2-s2.0-0034738789 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 63 | - |
dc.identifier.epage | 72 | - |
dc.identifier.isi | WOS:000088390100007 | - |
dc.identifier.issnl | 0168-3659 | - |