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Article: Sustained release of silver from periodontal wafers for treatment of periodontitis

TitleSustained release of silver from periodontal wafers for treatment of periodontitis
Authors
KeywordsPeriodontal wafers
Staining
Antimicrobial agent
Silver nitrate
Issue Date2000
Citation
Journal of Controlled Release, 2000, v. 68, n. 1, p. 63-72 How to Cite?
AbstractPeriodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. Copyright (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/230708
ISSN
2015 Impact Factor: 7.441
2015 SCImago Journal Rankings: 2.827

 

DC FieldValueLanguage
dc.contributor.authorBromberg, Lev E.-
dc.contributor.authorBraman, Virginia M.-
dc.contributor.authorRothstein, David M.-
dc.contributor.authorSpacciapoli, Peter-
dc.contributor.authorO'Connor, Sandra M.-
dc.contributor.authorNelson, Eric J.-
dc.contributor.authorBuxton, Debra K.-
dc.contributor.authorTonetti, Maurizio S.-
dc.contributor.authorFriden, Phillip M.-
dc.date.accessioned2016-09-01T06:06:36Z-
dc.date.available2016-09-01T06:06:36Z-
dc.date.issued2000-
dc.identifier.citationJournal of Controlled Release, 2000, v. 68, n. 1, p. 63-72-
dc.identifier.issn0168-3659-
dc.identifier.urihttp://hdl.handle.net/10722/230708-
dc.description.abstractPeriodontal wafers intended to treat the underlying infections in patients with periodontitis have been developed. The wafers consist of poly(lactic-co-glycolic acid) as a primary bioerodible polymeric component, poly(ethylene glycol) as a plasticizer and encapsulation aid, and silver nitrate as the antimicrobial agent. The wafers are capable of sustained in vitro release of bioactive silver for at least 4 weeks. The wafers exhibit silver release that follows erosion kinetics, confirming a bulk erosion/release mechanism. In clinical evaluation, sustained release of silver at bactericidal levels for at least 21 days is observed. Staining of hard and soft tissues due to the released silver is minimal and reversible. Copyright (C) 2000 Elsevier Science B.V.-
dc.languageeng-
dc.relation.ispartofJournal of Controlled Release-
dc.subjectPeriodontal wafers-
dc.subjectStaining-
dc.subjectAntimicrobial agent-
dc.subjectSilver nitrate-
dc.titleSustained release of silver from periodontal wafers for treatment of periodontitis-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0168-3659(00)00233-9-
dc.identifier.pmid10884580-
dc.identifier.scopuseid_2-s2.0-0034738789-
dc.identifier.volume68-
dc.identifier.issue1-
dc.identifier.spage63-
dc.identifier.epage72-

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