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Article: A Pontine Region is a Neural Correlate of the Human Affective Processing Network

TitleA Pontine Region is a Neural Correlate of the Human Affective Processing Network
Authors
Issue Date2015
PublisherElsevier - Open Access. The Journal's web site is located at http://www.ebiomedicine.com
Citation
EBioMedicine, 2015, v. 2 n. 11, p. 1799-1805 How to Cite?
AbstractThe in vivo neural activity of the pons during the perception of affective stimuli has not been studied despite the strong implications of its role in affective processing. To examine the activity of the pons during the viewing of affective stimuli, and to verify its functional and structural connectivity with other affective neural correlates, a multimodal magnetic resonance imaging methodology was employed in this study. We observed the in vivo activity of the pons when viewing affective stimuli. Furthermore, small-world connectivity indicated that the functional connectivity (FC) between the pons and the cortico-limbic affective regions was meaningful, with the coefficient λ being positively associated with self-reported emotional reactivity. The FC between the pons and the cortico-limbic-striatal areas was related to self-reported negative affect. Corroborating this finding was the observation that the tract passing through the pons and the left hippocampus was negatively related to self-reported positive affect and positively correlated with emotional reactivity. Our findings support the framework that the pons works conjunctively with the distributed cortico-limbic-striatal systems in shaping individuals' affective states and reactivity. Our work paves the path for future research on the contribution of the pons to the precipitation and maintenance of affective disorders.
Persistent Identifierhttp://hdl.handle.net/10722/230572
ISSN
2015 SCImago Journal Rankings: 1.304

 

DC FieldValueLanguage
dc.contributor.authorLee, TMC-
dc.contributor.authorSun, D-
dc.contributor.authorWONG, MLN-
dc.contributor.authorMen, W-
dc.contributor.authorGe, J-
dc.contributor.authorSo, KF-
dc.contributor.authorGao, J-
dc.contributor.authorChan, CCH-
dc.date.accessioned2016-08-23T14:17:49Z-
dc.date.available2016-08-23T14:17:49Z-
dc.date.issued2015-
dc.identifier.citationEBioMedicine, 2015, v. 2 n. 11, p. 1799-1805-
dc.identifier.issn2352-3964-
dc.identifier.urihttp://hdl.handle.net/10722/230572-
dc.description.abstractThe in vivo neural activity of the pons during the perception of affective stimuli has not been studied despite the strong implications of its role in affective processing. To examine the activity of the pons during the viewing of affective stimuli, and to verify its functional and structural connectivity with other affective neural correlates, a multimodal magnetic resonance imaging methodology was employed in this study. We observed the in vivo activity of the pons when viewing affective stimuli. Furthermore, small-world connectivity indicated that the functional connectivity (FC) between the pons and the cortico-limbic affective regions was meaningful, with the coefficient λ being positively associated with self-reported emotional reactivity. The FC between the pons and the cortico-limbic-striatal areas was related to self-reported negative affect. Corroborating this finding was the observation that the tract passing through the pons and the left hippocampus was negatively related to self-reported positive affect and positively correlated with emotional reactivity. Our findings support the framework that the pons works conjunctively with the distributed cortico-limbic-striatal systems in shaping individuals' affective states and reactivity. Our work paves the path for future research on the contribution of the pons to the precipitation and maintenance of affective disorders.-
dc.languageeng-
dc.publisherElsevier - Open Access. The Journal's web site is located at http://www.ebiomedicine.com-
dc.relation.ispartofEBioMedicine-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleA Pontine Region is a Neural Correlate of the Human Affective Processing Network-
dc.typeArticle-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.ebiom.2015.10.020-
dc.identifier.hkuros261589-
dc.identifier.hkuros261590-
dc.identifier.volume2-
dc.identifier.issue11-
dc.identifier.spage1799-
dc.identifier.epage1805-
dc.publisher.placeNetherlands-

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