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Article: Quantifying homologous and heterologous antibody titre rises after influenza virus infection

TitleQuantifying homologous and heterologous antibody titre rises after influenza virus infection
Authors
Issue Date2016
PublisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG
Citation
Epidemiology and Infection, 2016, v. 144 n. 11, p. 2306-2316 How to Cite?
AbstractMost influenza virus infections are associated with mild disease. One approach to estimate the occurrence of influenza virus infections in individuals is via repeated measurement of humoral antibody titres. We used baseline and convalescent antibody titres measured by haemagglutination inhibition (HI) and viral neutralization (VN) assays against influenza A(H1N1), A(H3N2) and B viruses to investigate the characteristics of antibody rises following virologically confirmed influenza virus infections in participants in a community-based study. Multivariate models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following influenza A virus infections. In 122 participants with PCR-confirmed influenza A virus infection, homologous antibody titres rose by geometric means of 1·2- to 10·2-fold after infection with A(H1N1), A(H3N2) and A(H1N1)pdm09. Significant cross-reactions were observed between A(H1N1)pdm09 and seasonal A(H1N1). Antibody titre rises for some subtypes and assays varied by age, receipt of oseltamivir treatment, and recent receipt of influenza vaccination. In conclusion, we provided a quantitative description of the mean and variation in rises in influenza virus antibody titres following influenza virus infection. The multivariate patterns in boosting of antibody titres following influenza virus infection could be taken into account to improve estimates of cumulative incidence of infection in seroepidemiological studies.
Persistent Identifierhttp://hdl.handle.net/10722/230492
ISSN
2017 Impact Factor: 2.044
2015 SCImago Journal Rankings: 1.320
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFreeman, G-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorNgan, E-
dc.contributor.authorFang, J-
dc.contributor.authorCauchemez, ST-
dc.contributor.authorIp, DKM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2016-08-23T14:17:21Z-
dc.date.available2016-08-23T14:17:21Z-
dc.date.issued2016-
dc.identifier.citationEpidemiology and Infection, 2016, v. 144 n. 11, p. 2306-2316-
dc.identifier.issn0950-2688-
dc.identifier.urihttp://hdl.handle.net/10722/230492-
dc.description.abstractMost influenza virus infections are associated with mild disease. One approach to estimate the occurrence of influenza virus infections in individuals is via repeated measurement of humoral antibody titres. We used baseline and convalescent antibody titres measured by haemagglutination inhibition (HI) and viral neutralization (VN) assays against influenza A(H1N1), A(H3N2) and B viruses to investigate the characteristics of antibody rises following virologically confirmed influenza virus infections in participants in a community-based study. Multivariate models were fitted in a Bayesian framework to characterize the distribution of changes in antibody titres following influenza A virus infections. In 122 participants with PCR-confirmed influenza A virus infection, homologous antibody titres rose by geometric means of 1·2- to 10·2-fold after infection with A(H1N1), A(H3N2) and A(H1N1)pdm09. Significant cross-reactions were observed between A(H1N1)pdm09 and seasonal A(H1N1). Antibody titre rises for some subtypes and assays varied by age, receipt of oseltamivir treatment, and recent receipt of influenza vaccination. In conclusion, we provided a quantitative description of the mean and variation in rises in influenza virus antibody titres following influenza virus infection. The multivariate patterns in boosting of antibody titres following influenza virus infection could be taken into account to improve estimates of cumulative incidence of infection in seroepidemiological studies.-
dc.languageeng-
dc.publisherCambridge University Press. The Journal's web site is located at http://journals.cambridge.org/action/displayJournal?jid=HYG-
dc.relation.ispartofEpidemiology and Infection-
dc.rightsEpidemiology and Infection. Copyright © Cambridge University Press.-
dc.rightsThis article has been published in a revised form in [Journal] [http://doi.org/XXX]. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.-
dc.titleQuantifying homologous and heterologous antibody titre rises after influenza virus infection-
dc.typeArticle-
dc.identifier.emailFreeman, G: gfreeman@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailFang, J: vickyf@hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityFreeman, G=rp01694-
dc.identifier.authorityPerera, RAPM=rp02500-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1017/S0950268816000583-
dc.identifier.pmid27018720-
dc.identifier.scopuseid_2-s2.0-84961943347-
dc.identifier.hkuros260246-
dc.identifier.volume144-
dc.identifier.issue11-
dc.identifier.spage2306-
dc.identifier.epage2316-
dc.identifier.isiWOS:000379785200009-
dc.publisher.placeUnited Kingdom-

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