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Conference Paper: Relationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus

TitleRelationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 19th Medical Research Conference (MRC 2014), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 51, abstract no. 84 How to Cite?
AbstractBACKGROUND: Diabetic mellitus (DM) patients may have cardiac structure and functional changes or microvascular disease in the absence of cardiovascular disease history. The relationship between the occurrence of diabetic microvascular disease and cardiac change in DM patients without a history of heart trouble is unclear. The present study sought the correlation between diabetic retinopathy, which is one kind of microvascular disease, and cardiac functional changes by (a) basic ophthalmic testing and (b) detailed echocardiography for cardiac assessment. METHODS: A total of 251 patients with type 2 DM without cardiovascular diseases were recruited. Transthoracic echocardiography was performed at the rest state as well as after treadmill exercise and analysed in detail with the following parameters: (i) left ventricle (LV) systolic function was assessed by Simpson’s method derived ejection fraction (EF) and speckle tracking derived global longitudinal strain (GLS), (ii) myocardial structural alteration by calibrated integrated backscatter (cIBS), (iii) diastolic function by tissue Doppler derived E/E’ ratio, and (iv) diastolic function reserve index (DFRI). Furthermore, all patients undertook a full-fledged photography programme. Retinopathy was scored and classified as with retinopathy or without diabetic retinopathy. RESULTS: Of the 251 subjects (mean age, 63.13 ± 9.31 years; 46.2% male), 24.3% had retinopathy. Patients with and without diabetic retinopathy (as a categorical variable) had similar LVEF and cIBS. However, retinopathy had a significant correlation with LV GLS (r = –0.18, P < 0.01), E/E’ (r = 0.19, P < 0.01), diastolic dysfunction grade (r = 0.18, P < 0.01), and DFRI (r = –0.23, P = 0.02). Furthermore, these correlations were independent of potential confounding factors. CONCLUSION: This study indicated that the occurrence of retinopathy significantly correlates with GLS, E/E’, diastolic dysfunction grade, and DFRI. Above all, the correlation still existed after adjusted by potential confounding factors, suggestive of an independent relation between retinopathy and cardiac function. The link between these parameters highlighted the importance of further cardiac assessment and timely treatment for DM patients with diabetic retinopathy who have no cardiac disease history and relevant symptoms.
DescriptionPoster
Persistent Identifierhttp://hdl.handle.net/10722/229858
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorZhen, Z-
dc.contributor.authorWong, CKA-
dc.contributor.authorChen, Y-
dc.contributor.authorZhao, CT-
dc.contributor.authorSiu, DCW-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2016-08-23T14:13:40Z-
dc.date.available2016-08-23T14:13:40Z-
dc.date.issued2014-
dc.identifier.citationThe 19th Medical Research Conference (MRC 2014), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 suppl. 1, p. 51, abstract no. 84-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/229858-
dc.descriptionPoster-
dc.description.abstractBACKGROUND: Diabetic mellitus (DM) patients may have cardiac structure and functional changes or microvascular disease in the absence of cardiovascular disease history. The relationship between the occurrence of diabetic microvascular disease and cardiac change in DM patients without a history of heart trouble is unclear. The present study sought the correlation between diabetic retinopathy, which is one kind of microvascular disease, and cardiac functional changes by (a) basic ophthalmic testing and (b) detailed echocardiography for cardiac assessment. METHODS: A total of 251 patients with type 2 DM without cardiovascular diseases were recruited. Transthoracic echocardiography was performed at the rest state as well as after treadmill exercise and analysed in detail with the following parameters: (i) left ventricle (LV) systolic function was assessed by Simpson’s method derived ejection fraction (EF) and speckle tracking derived global longitudinal strain (GLS), (ii) myocardial structural alteration by calibrated integrated backscatter (cIBS), (iii) diastolic function by tissue Doppler derived E/E’ ratio, and (iv) diastolic function reserve index (DFRI). Furthermore, all patients undertook a full-fledged photography programme. Retinopathy was scored and classified as with retinopathy or without diabetic retinopathy. RESULTS: Of the 251 subjects (mean age, 63.13 ± 9.31 years; 46.2% male), 24.3% had retinopathy. Patients with and without diabetic retinopathy (as a categorical variable) had similar LVEF and cIBS. However, retinopathy had a significant correlation with LV GLS (r = –0.18, P < 0.01), E/E’ (r = 0.19, P < 0.01), diastolic dysfunction grade (r = 0.18, P < 0.01), and DFRI (r = –0.23, P = 0.02). Furthermore, these correlations were independent of potential confounding factors. CONCLUSION: This study indicated that the occurrence of retinopathy significantly correlates with GLS, E/E’, diastolic dysfunction grade, and DFRI. Above all, the correlation still existed after adjusted by potential confounding factors, suggestive of an independent relation between retinopathy and cardiac function. The link between these parameters highlighted the importance of further cardiac assessment and timely treatment for DM patients with diabetic retinopathy who have no cardiac disease history and relevant symptoms.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleRelationship between diabetic retinopathy and subclinical myocardial dysfunction in patients with diabetic mellitus-
dc.typeConference_Paper-
dc.identifier.emailZhao, CT: tingirl@hku.hk-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authoritySiu, DCW=rp00534-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.hkuros262992-
dc.identifier.volume20-
dc.identifier.issuesuppl. 1-
dc.identifier.spage51, abstract no. 84-
dc.identifier.epage51, abstract no. 84-
dc.publisher.placeHong Kong-

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