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Article: Molecular components of Wnt/B-catenin pathway as therapeutic targets for upper gastrointestinal cancers

TitleMolecular components of Wnt/B-catenin pathway as therapeutic targets for upper gastrointestinal cancers
Authors
KeywordsWnt
Esophageal cancer
Gastric cancer
Therapeutic target
Issue Date2015
PublisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.benthamscience.com/ccand/index.htm
Citation
Clinical Cancer Drugs, 2015, v. 2 n. 2, p. 72-79 How to Cite?
AbstractBackground: Worldwide, esophageal and gastric cancers are the two most frequent cancers associated with the upper gastrointestinal tract. These two types of cancers alone account for nearly a million deaths annually. Most patients when first diagnosed are already in advanced stage of the disease, where frontline treatments such as surgical resection are ineffective. Alternative treatments such as chemotherapy, radiotherapy and targeted therapies are the remaining options for this group of inoperable patients, though each of these treatment options has its own limitations and disadvantages. Discussion: To improve current cancer management, new treatment directions are needed. In the recent decade, Wnt/β-catenin pathway is emerging as a hallmark of various types of malignancies including esophageal and gastric cancers. Its activation is manifested by alteration and deregulation of the core components of this pathway. Conclusion: Identification of key deregulated components along this pathway has opened up a new avenue of research to combat esophageal and gastric cancers by targeting these components to counteract tumorigenesis.
Persistent Identifierhttp://hdl.handle.net/10722/229510
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLee, P-
dc.contributor.authorXu, Z-
dc.contributor.authorFatima, S-
dc.contributor.authorYung, TT-
dc.contributor.authorSun, RWY-
dc.contributor.authorLaw, S-
dc.date.accessioned2016-08-23T14:11:35Z-
dc.date.available2016-08-23T14:11:35Z-
dc.date.issued2015-
dc.identifier.citationClinical Cancer Drugs, 2015, v. 2 n. 2, p. 72-79-
dc.identifier.issn2212-697X-
dc.identifier.urihttp://hdl.handle.net/10722/229510-
dc.description.abstractBackground: Worldwide, esophageal and gastric cancers are the two most frequent cancers associated with the upper gastrointestinal tract. These two types of cancers alone account for nearly a million deaths annually. Most patients when first diagnosed are already in advanced stage of the disease, where frontline treatments such as surgical resection are ineffective. Alternative treatments such as chemotherapy, radiotherapy and targeted therapies are the remaining options for this group of inoperable patients, though each of these treatment options has its own limitations and disadvantages. Discussion: To improve current cancer management, new treatment directions are needed. In the recent decade, Wnt/β-catenin pathway is emerging as a hallmark of various types of malignancies including esophageal and gastric cancers. Its activation is manifested by alteration and deregulation of the core components of this pathway. Conclusion: Identification of key deregulated components along this pathway has opened up a new avenue of research to combat esophageal and gastric cancers by targeting these components to counteract tumorigenesis.-
dc.languageeng-
dc.publisherBentham Science Publishers Ltd. The Journal's web site is located at http://www.benthamscience.com/ccand/index.htm-
dc.relation.ispartofClinical Cancer Drugs-
dc.subjectWnt-
dc.subjectEsophageal cancer-
dc.subjectGastric cancer-
dc.subjectTherapeutic target-
dc.titleMolecular components of Wnt/B-catenin pathway as therapeutic targets for upper gastrointestinal cancers-
dc.typeArticle-
dc.identifier.emailLee, P: nikkilee@hku.hk-
dc.identifier.emailLaw, S: slaw@hkucc.hku.hk-
dc.identifier.authorityLee, P=rp00263-
dc.identifier.authorityLaw, S=rp00437-
dc.identifier.hkuros262001-
dc.identifier.volume2-
dc.identifier.issue2-
dc.identifier.spage72-
dc.identifier.epage79-
dc.publisher.placeNetherlands-

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