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Article: Myocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans

TitleMyocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans
Authors
Issue Date2016
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal of Anaesthesia, 2016, v. 117 n. Suppl. 2, p. ii44-ii62 How to Cite?
AbstractMyocardial ischaemia reperfusion injury is the leading cause of death in patients with cardiovascular disease. Interventions such as ischaemic pre and postconditioning protect against myocardial ischaemia reperfusion injury. Certain anaesthesia drugs and opioids can produce the same effects, which led to an initial flurry of excitement given the extensive use of these drugs in surgery. The underlying mechanisms have since been extensively studied in experimental animal models but attempts to translate these findings to clinical settings have resulted in contradictory results. There are a number of reasons for this such as dose response, the intensity of the ischaemic stimulus applied, the duration of ischaemia and lost or diminished cardioprotection in common co-morbidities such as diabetes and senescence. This review focuses on current knowledge regarding myocardial ischaemia reperfusion injury and cardioprotective interventions both in experimental animal studies and in clinical trials.
Persistent Identifierhttp://hdl.handle.net/10722/229096
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314

 

DC FieldValueLanguage
dc.contributor.authorXia, Z-
dc.contributor.authorLi, H-
dc.contributor.authorIrwin, MG-
dc.date.accessioned2016-08-23T14:08:58Z-
dc.date.available2016-08-23T14:08:58Z-
dc.date.issued2016-
dc.identifier.citationBritish Journal of Anaesthesia, 2016, v. 117 n. Suppl. 2, p. ii44-ii62-
dc.identifier.issn0007-0912-
dc.identifier.urihttp://hdl.handle.net/10722/229096-
dc.description.abstractMyocardial ischaemia reperfusion injury is the leading cause of death in patients with cardiovascular disease. Interventions such as ischaemic pre and postconditioning protect against myocardial ischaemia reperfusion injury. Certain anaesthesia drugs and opioids can produce the same effects, which led to an initial flurry of excitement given the extensive use of these drugs in surgery. The underlying mechanisms have since been extensively studied in experimental animal models but attempts to translate these findings to clinical settings have resulted in contradictory results. There are a number of reasons for this such as dose response, the intensity of the ischaemic stimulus applied, the duration of ischaemia and lost or diminished cardioprotection in common co-morbidities such as diabetes and senescence. This review focuses on current knowledge regarding myocardial ischaemia reperfusion injury and cardioprotective interventions both in experimental animal studies and in clinical trials.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/-
dc.relation.ispartofBritish Journal of Anaesthesia-
dc.rightsThis is an electronic version of an article published in British Journal of Anaesthesia. The definitive publisher-authenticated version British Journal of Anaesthesia, 2016, v. 117 n. Suppl. 2, p. ii44-ii62 is available online at: http://bja.oxfordjournals.org/content/117/suppl_2/ii44-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMyocardial ischaemia reperfusion injury: the challenge of translating ischaemic and anaesthetic protection from animal models to humans-
dc.typeArticle-
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hk-
dc.identifier.emailLi, H: lihaobo@hku.hk-
dc.identifier.emailIrwin, MG: mgirwin@hku.hk-
dc.identifier.authorityXia, Z=rp00532-
dc.identifier.authorityIrwin, MG=rp00390-
dc.description.naturepostprint-
dc.identifier.doi10.1093/bja/aew267-
dc.identifier.pmid27566808-
dc.identifier.hkuros261652-
dc.identifier.volume117-
dc.identifier.issueSuppl. 2-
dc.identifier.spageii44-
dc.identifier.epageii62-
dc.publisher.placeUnited Kingdom-

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