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Article: Longitudinal changes of cardiac structure and function in CKD (CASCADE study)

TitleLongitudinal changes of cardiac structure and function in CKD (CASCADE study)
Authors
Issue Date2014
Citation
Journal of the American Society of Nephrology, 2014, v. 25, n. 7, p. 1599-1608 How to Cite?
AbstractCopyright © 2014 by the American Society of Nephrology.Little is known regarding the natural longitudinal changes in cardiac structure and function in CKD. We hypothesized that baseline CKD stage is associated with progressive worsening in cardiac structure and function. We conducted a prospective longitudinal study, recruiting 300 patients with stages 3-5 CKD from a major regional tertiary center and university teaching hospital in Hong Kong. Baseline CKD stages were studied in relation to natural longitudinal changes in echocardiographic and tissue Doppler imaging- derived parameters. Over 1 year, the prevalence of left ventricular (LV) hypertrophy increased from40.3% to 48.9%, median left atrial volume index increased 4.8 (interquartile range [IQR], 2.1, 7.7) ml/m2 (P<0.001), peak systolic mitral annular velocity decreased 0.5 (IQR, 21.5, 0.5) cm/s (P<0.001), early diastolic mitral annular velocity decreased 0.5 (IQR, 21.5, 0.5) cm/s (P<0.001), and eGFR declined 2.0 (IQR, 25.0, 0.0)ml/min per 1.73m2. CKD stages 4 and 5 were associated with more baseline abnormalities in cardiac structure and function and predicted greater longitudinal progression in LV mass index (odds ratio [OR], 3.02; 95% confidence interval [95% CI], 1.39 to 6.58), volume index (OR, 2.58; 95% CI, 1.18 to 5.62), and left atrial volume index (OR, 2.61; 95% CI, 1.20 to 5.69) and worse diastolic dysfunction grade (OR, 3.17; 95% CI, 1.16 to 8.69) compared with stage 3a in the fully adjusted analysis. In conclusion, more advanced CKD at baselinemay be associated with larger longitudinal increases in LV mass and volume and greater deterioration in diastolic function.
Persistent Identifierhttp://hdl.handle.net/10722/228479
ISSN
2015 Impact Factor: 8.491
2015 SCImago Journal Rankings: 4.699

 

DC FieldValueLanguage
dc.contributor.authorCai, Qi Zhe-
dc.contributor.authorLu, Xiu Zhang-
dc.contributor.authorLu, Ye-
dc.contributor.authorWang, Angela Yee Moon-
dc.date.accessioned2016-08-13T08:02:31Z-
dc.date.available2016-08-13T08:02:31Z-
dc.date.issued2014-
dc.identifier.citationJournal of the American Society of Nephrology, 2014, v. 25, n. 7, p. 1599-1608-
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/228479-
dc.description.abstractCopyright © 2014 by the American Society of Nephrology.Little is known regarding the natural longitudinal changes in cardiac structure and function in CKD. We hypothesized that baseline CKD stage is associated with progressive worsening in cardiac structure and function. We conducted a prospective longitudinal study, recruiting 300 patients with stages 3-5 CKD from a major regional tertiary center and university teaching hospital in Hong Kong. Baseline CKD stages were studied in relation to natural longitudinal changes in echocardiographic and tissue Doppler imaging- derived parameters. Over 1 year, the prevalence of left ventricular (LV) hypertrophy increased from40.3% to 48.9%, median left atrial volume index increased 4.8 (interquartile range [IQR], 2.1, 7.7) ml/m2 (P<0.001), peak systolic mitral annular velocity decreased 0.5 (IQR, 21.5, 0.5) cm/s (P<0.001), early diastolic mitral annular velocity decreased 0.5 (IQR, 21.5, 0.5) cm/s (P<0.001), and eGFR declined 2.0 (IQR, 25.0, 0.0)ml/min per 1.73m2. CKD stages 4 and 5 were associated with more baseline abnormalities in cardiac structure and function and predicted greater longitudinal progression in LV mass index (odds ratio [OR], 3.02; 95% confidence interval [95% CI], 1.39 to 6.58), volume index (OR, 2.58; 95% CI, 1.18 to 5.62), and left atrial volume index (OR, 2.61; 95% CI, 1.20 to 5.69) and worse diastolic dysfunction grade (OR, 3.17; 95% CI, 1.16 to 8.69) compared with stage 3a in the fully adjusted analysis. In conclusion, more advanced CKD at baselinemay be associated with larger longitudinal increases in LV mass and volume and greater deterioration in diastolic function.-
dc.languageeng-
dc.relation.ispartofJournal of the American Society of Nephrology-
dc.titleLongitudinal changes of cardiac structure and function in CKD (CASCADE study)-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1681/ASN.2013080899-
dc.identifier.pmid24525033-
dc.identifier.scopuseid_2-s2.0-84907226628-
dc.identifier.volume25-
dc.identifier.issue7-
dc.identifier.spage1599-
dc.identifier.epage1608-
dc.identifier.eissn1533-3450-

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