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Article: Skin autofluorescence associates with vascular calcification in chronic kidney disease

TitleSkin autofluorescence associates with vascular calcification in chronic kidney disease
Authors
KeywordsAdvanced
Issue Date2014
Citation
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014, v. 34, n. 8, p. 1784-1790 How to Cite?
AbstractObjective - This study aims to evaluate the relationship between tissue advanced glycation end products, as reflected by skin autofluorescence, and vascular calcification in chronic kidney disease. Approach And Results - Three hundred patients with stage 3 to 5 chronic kidney disease underwent multislice computed tomography to estimate total coronary artery calcium score (CACS) and had tissue advanced glycation end product assessed using a skin autofluorescence reader. Intact parathyroid hormone (P<0.001) displaced estimated glomerular filtration rate as third most significant factor associated with skin autofluorescence after age (P<0.001) and diabetes mellitus (P<0.001) in multiple regression analysis. On univariate multinomial logistic regression analysis, every 1-U increase in skin autofluorescence was associated with a 7.43-fold (95% confidence intervals, 3.59-15.37; P<0.001) increased odds of having CACS ≥400 compared with those with zero CACS. Skin autofluorescence retained significance in predicting CACS ≥400 (odds ratio, 3.63; 95% confidence intervals, 1.44-9.18; P=0.006) when adjusting for age, sex, serum calcium, phosphate, albumin, C-reactive protein, lipids, blood pressure, estimated glomerular filtration rate, and intact parathyroid hormone but marginally lost significance when additionally adjusting for diabetes mellitus (odds ratio, 2.23; 95% confidence intervals, 0.81-6.14; P=0.1). Combination of diabetes mellitus and higher intact parathyroid hormone was associated with greater skin autofluorescence and CACS versus those without diabetes mellitus and having lower intact parathyroid hormone. Conclusions - Tissue advanced glycation end product, as reflected by skin autofluorescence, showed a significant novel association with vascular calcification in chronic kidney disease. These data suggest that increased tissue advanced glycation end product may contribute to vascular calcification in chronic kidney disease and diabetes mellitus and warrant further experimental investigation. © 2014 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/228478
ISSN
2015 Impact Factor: 5.969
2015 SCImago Journal Rankings: 3.356

 

DC FieldValueLanguage
dc.contributor.authorWang, Angela Yee Moon-
dc.contributor.authorWong, Chun Kwok-
dc.contributor.authorYau, Yat Yin-
dc.contributor.authorWong, Sharon-
dc.contributor.authorChan, Iris Hiu Shuen-
dc.contributor.authorLam, Christopher Wai Kei-
dc.date.accessioned2016-08-13T08:02:31Z-
dc.date.available2016-08-13T08:02:31Z-
dc.date.issued2014-
dc.identifier.citationArteriosclerosis, Thrombosis, and Vascular Biology, 2014, v. 34, n. 8, p. 1784-1790-
dc.identifier.issn1079-5642-
dc.identifier.urihttp://hdl.handle.net/10722/228478-
dc.description.abstractObjective - This study aims to evaluate the relationship between tissue advanced glycation end products, as reflected by skin autofluorescence, and vascular calcification in chronic kidney disease. Approach And Results - Three hundred patients with stage 3 to 5 chronic kidney disease underwent multislice computed tomography to estimate total coronary artery calcium score (CACS) and had tissue advanced glycation end product assessed using a skin autofluorescence reader. Intact parathyroid hormone (P<0.001) displaced estimated glomerular filtration rate as third most significant factor associated with skin autofluorescence after age (P<0.001) and diabetes mellitus (P<0.001) in multiple regression analysis. On univariate multinomial logistic regression analysis, every 1-U increase in skin autofluorescence was associated with a 7.43-fold (95% confidence intervals, 3.59-15.37; P<0.001) increased odds of having CACS ≥400 compared with those with zero CACS. Skin autofluorescence retained significance in predicting CACS ≥400 (odds ratio, 3.63; 95% confidence intervals, 1.44-9.18; P=0.006) when adjusting for age, sex, serum calcium, phosphate, albumin, C-reactive protein, lipids, blood pressure, estimated glomerular filtration rate, and intact parathyroid hormone but marginally lost significance when additionally adjusting for diabetes mellitus (odds ratio, 2.23; 95% confidence intervals, 0.81-6.14; P=0.1). Combination of diabetes mellitus and higher intact parathyroid hormone was associated with greater skin autofluorescence and CACS versus those without diabetes mellitus and having lower intact parathyroid hormone. Conclusions - Tissue advanced glycation end product, as reflected by skin autofluorescence, showed a significant novel association with vascular calcification in chronic kidney disease. These data suggest that increased tissue advanced glycation end product may contribute to vascular calcification in chronic kidney disease and diabetes mellitus and warrant further experimental investigation. © 2014 American Heart Association, Inc.-
dc.languageeng-
dc.relation.ispartofArteriosclerosis, Thrombosis, and Vascular Biology-
dc.subjectAdvanced-
dc.titleSkin autofluorescence associates with vascular calcification in chronic kidney disease-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1161/ATVBAHA.114.303378-
dc.identifier.pmid24876353-
dc.identifier.scopuseid_2-s2.0-84904698596-
dc.identifier.volume34-
dc.identifier.issue8-
dc.identifier.spage1784-
dc.identifier.epage1790-
dc.identifier.eissn1524-4636-

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