File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cefazolin plus ceftazidime versus imipenem/cilastatin monotherapy for treatment of CAPD peritonitis - A randomized controlled trial

TitleCefazolin plus ceftazidime versus imipenem/cilastatin monotherapy for treatment of CAPD peritonitis - A randomized controlled trial
Authors
KeywordsAntibiotic
Issue Date2004
Citation
Peritoneal Dialysis International, 2004, v. 24, n. 5, p. 440-446 How to Cite?
Abstract◆ Background: Peritonitis is a serious complication of peritoneal dialysis (PD). We studied the efficacy of imipenem / cilastatin monotherapy in the treatment of PD-related peritonitis. ◆ Methods: We performed an open-label, randomized control study comparing imipenem / cilastatin monotherapy (treatment group) versus cefazolin plus ceftazidime (control group) in the treatment of PD peritonitis. The result was further compared to a historic group treated with cefazolin plus netilmycin. Outcome measures were primary response rate at day 10 and complete cure rate. ◆ Results:We enrolled 51 patients in the treatment group, 51 in the control group, and identified 96 in the historic group. The primary response rate to the assigned antibiotics was 49.0%, 51.0%, and 49.0% for the treatment, control, and historic groups, respectively (p = 0.97). The primary response rate allowing for change in antibiotic was 82.4%, 90.2%, and 82.3%, respectively, for the three groups (p = 0.41). The complete cure rate was 72.5%, 80.4%, and 82.3%, respectively (p = 0.60). Tenckhoff catheter removal was needed in 6 cases in the treatment group, 6 cases in the control group, and 13 cases in the historic group (p = 0.90). ◆ Conclusions: We concluded that monotherapy of imipenem / cilastatin has similar efficacy compared to the two standard regimens of cefazolin plus ceftazidime or netilmycin in the treatment of PD peritonitis. Copyright © 2004 International Society for Peritoneal Dialysis.
Persistent Identifierhttp://hdl.handle.net/10722/228459
ISSN
2015 Impact Factor: 1.298
2015 SCImago Journal Rankings: 0.683

 

DC FieldValueLanguage
dc.contributor.authorLeung, Chi B.-
dc.contributor.authorSzeto, Cheuk Chun-
dc.contributor.authorChow, Kai Ming-
dc.contributor.authorKwan, B. C H-
dc.contributor.authorWang, A. Y M-
dc.contributor.authorLui, Siu F.-
dc.contributor.authorLi, P. K T-
dc.date.accessioned2016-08-13T08:02:28Z-
dc.date.available2016-08-13T08:02:28Z-
dc.date.issued2004-
dc.identifier.citationPeritoneal Dialysis International, 2004, v. 24, n. 5, p. 440-446-
dc.identifier.issn0896-8608-
dc.identifier.urihttp://hdl.handle.net/10722/228459-
dc.description.abstract◆ Background: Peritonitis is a serious complication of peritoneal dialysis (PD). We studied the efficacy of imipenem / cilastatin monotherapy in the treatment of PD-related peritonitis. ◆ Methods: We performed an open-label, randomized control study comparing imipenem / cilastatin monotherapy (treatment group) versus cefazolin plus ceftazidime (control group) in the treatment of PD peritonitis. The result was further compared to a historic group treated with cefazolin plus netilmycin. Outcome measures were primary response rate at day 10 and complete cure rate. ◆ Results:We enrolled 51 patients in the treatment group, 51 in the control group, and identified 96 in the historic group. The primary response rate to the assigned antibiotics was 49.0%, 51.0%, and 49.0% for the treatment, control, and historic groups, respectively (p = 0.97). The primary response rate allowing for change in antibiotic was 82.4%, 90.2%, and 82.3%, respectively, for the three groups (p = 0.41). The complete cure rate was 72.5%, 80.4%, and 82.3%, respectively (p = 0.60). Tenckhoff catheter removal was needed in 6 cases in the treatment group, 6 cases in the control group, and 13 cases in the historic group (p = 0.90). ◆ Conclusions: We concluded that monotherapy of imipenem / cilastatin has similar efficacy compared to the two standard regimens of cefazolin plus ceftazidime or netilmycin in the treatment of PD peritonitis. Copyright © 2004 International Society for Peritoneal Dialysis.-
dc.languageeng-
dc.relation.ispartofPeritoneal Dialysis International-
dc.subjectAntibiotic-
dc.titleCefazolin plus ceftazidime versus imipenem/cilastatin monotherapy for treatment of CAPD peritonitis - A randomized controlled trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid15490983-
dc.identifier.scopuseid_2-s2.0-7444265834-
dc.identifier.volume24-
dc.identifier.issue5-
dc.identifier.spage440-
dc.identifier.epage446-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats