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Article: DRG11 immunohistochemical expression during embryonic development in the mouse

TitleDRG11 immunohistochemical expression during embryonic development in the mouse
Authors
KeywordsBrainstem
Issue Date2007
Citation
Developmental Dynamics, 2007, v. 236, n. 9, p. 2653-2660 How to Cite?
AbstractDRG11 is a paired domain transcription factor that is necessary for the assembly of the nociceptive circuitry in the spinal cord dorsal horn. It is expressed in small dorsal root ganglion (DRG) neurons and in their projection area in the spinal cord. Drg11 knockout mice exhibit structural and neurochemical defects both at the DRG and spinal superficial dorsal horn and present reduced nociceptive responses. In this study, a polyclonal antibody against DRG11 was generated and used for a detailed systematic spatiotemporal analysis of DRG11 expression during development. DRG11 is first detected at E10.5 in the spinal dorsal horn, DRG and trigeminal ganglion, where it persists until P14-21. At the cranial level, DRG11 expression is observed from E10.5 up to the same early post-natal ages in several cranial sensory ganglia and brain nuclei. These results suggest that DRG11 is required for the establishment of the first neuronal sensory relay along development. © 2007 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/228049
ISSN
2015 Impact Factor: 2.198
2015 SCImago Journal Rankings: 1.726

 

DC FieldValueLanguage
dc.contributor.authorRebelo, Sandra-
dc.contributor.authorReguenga, Carlos-
dc.contributor.authorOsório, Liliana-
dc.contributor.authorPereira, Carlos-
dc.contributor.authorLopes, Claúdia-
dc.contributor.authorLima, Deolinda-
dc.date.accessioned2016-08-01T06:45:03Z-
dc.date.available2016-08-01T06:45:03Z-
dc.date.issued2007-
dc.identifier.citationDevelopmental Dynamics, 2007, v. 236, n. 9, p. 2653-2660-
dc.identifier.issn1058-8388-
dc.identifier.urihttp://hdl.handle.net/10722/228049-
dc.description.abstractDRG11 is a paired domain transcription factor that is necessary for the assembly of the nociceptive circuitry in the spinal cord dorsal horn. It is expressed in small dorsal root ganglion (DRG) neurons and in their projection area in the spinal cord. Drg11 knockout mice exhibit structural and neurochemical defects both at the DRG and spinal superficial dorsal horn and present reduced nociceptive responses. In this study, a polyclonal antibody against DRG11 was generated and used for a detailed systematic spatiotemporal analysis of DRG11 expression during development. DRG11 is first detected at E10.5 in the spinal dorsal horn, DRG and trigeminal ganglion, where it persists until P14-21. At the cranial level, DRG11 expression is observed from E10.5 up to the same early post-natal ages in several cranial sensory ganglia and brain nuclei. These results suggest that DRG11 is required for the establishment of the first neuronal sensory relay along development. © 2007 Wiley-Liss, Inc.-
dc.languageeng-
dc.relation.ispartofDevelopmental Dynamics-
dc.subjectBrainstem-
dc.titleDRG11 immunohistochemical expression during embryonic development in the mouse-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/dvdy.21271-
dc.identifier.pmid17676639-
dc.identifier.scopuseid_2-s2.0-34548837504-
dc.identifier.volume236-
dc.identifier.issue9-
dc.identifier.spage2653-
dc.identifier.epage2660-
dc.identifier.eissn1097-0177-

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