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Article: Cholinergic modulation of spike timing and spike rate

TitleCholinergic modulation of spike timing and spike rate
Authors
KeywordsAcetylcholine
Issue Date1999
Citation
Neurocomputing, 1999, v. 26-27, p. 293-298 How to Cite?
AbstractLittle is known about the constraints that neuromodulation places upon neural coding. We investigated the relationship between cholinergic modulation of spike timing and rate in a compartment model of a neocortical neuron. Our results suggest that cholinergic modulation of spike timing is directly related to the modulation of spike rate via the insertion of new spikes, and that spike timing is best preserved when the firing rate is low, i.e., when a rate code is ineffective (Thorpe et al., Nature 381 (6582) (1996) 520-522). We propose that neocortical neurons may use a spike timing and a rate code complementarily in different portions of their dynamic range.
Persistent Identifierhttp://hdl.handle.net/10722/228006
ISSN
2015 Impact Factor: 2.392
2015 SCImago Journal Rankings: 1.202

 

DC FieldValueLanguage
dc.contributor.authorTang, Akaysha C.-
dc.contributor.authorWolfe, Jonathan-
dc.contributor.authorBartels, Andreas M.-
dc.date.accessioned2016-08-01T06:44:57Z-
dc.date.available2016-08-01T06:44:57Z-
dc.date.issued1999-
dc.identifier.citationNeurocomputing, 1999, v. 26-27, p. 293-298-
dc.identifier.issn0925-2312-
dc.identifier.urihttp://hdl.handle.net/10722/228006-
dc.description.abstractLittle is known about the constraints that neuromodulation places upon neural coding. We investigated the relationship between cholinergic modulation of spike timing and rate in a compartment model of a neocortical neuron. Our results suggest that cholinergic modulation of spike timing is directly related to the modulation of spike rate via the insertion of new spikes, and that spike timing is best preserved when the firing rate is low, i.e., when a rate code is ineffective (Thorpe et al., Nature 381 (6582) (1996) 520-522). We propose that neocortical neurons may use a spike timing and a rate code complementarily in different portions of their dynamic range.-
dc.languageeng-
dc.relation.ispartofNeurocomputing-
dc.subjectAcetylcholine-
dc.titleCholinergic modulation of spike timing and spike rate-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0925-2312(99)00072-7-
dc.identifier.scopuseid_2-s2.0-0032871937-
dc.identifier.volume26-27-
dc.identifier.spage293-
dc.identifier.epage298-

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