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Article: Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes

TitleEvolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes
Authors
Issue Date2015
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2015, v. 10 n. 9, p. e0135940 How to Cite?
AbstractBackground Photolyases and cryptochromes are evolutionarily related flavoproteins, which however perform distinct physiological functions. Photolyases (PHR) are evolutionarily ancient enzymes. They are activated by light and repair DNA damage caused by UV radiation. Although cryptochromes share structural similarity with DNA photolyases, they lack DNA repair activity. Cryptochrome (CRY) is one of the key elements of the circadian system in animals. In plants, CRY acts as a blue light receptor to entrain circadian rhythms, and mediates a variety of light responses, such as the regulation of flowering and seedling growth. Results We performed a comprehensive evolutionary analysis of the CRY/PHR superfamily. The superfamily consists of 7 major subfamilies: CPD class I and CPD class II photolyases, (6-4) photolyases, CRY-DASH, plant PHR2, plant CRY and animal CRY. Although the whole superfamily evolved primarily under strong purifying selection (average omega = 0.0168), some subfamilies did experience strong episodic positive selection during their evolution. Photolyases were lost in higher animals that suggests natural selection apparently became weaker in the late stage of evolutionary history. The evolutionary time estimates suggested that plant and animal CRYs evolved in the Neoproterozoic Era (similar to 1000-541 Mya), which might be a result of adaptation to the major climate and global light regime changes occurred in that period of the Earth's geological history.
Persistent Identifierhttp://hdl.handle.net/10722/227850
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMei, Q-
dc.contributor.authorDvornyk, V-
dc.date.accessioned2016-07-20T03:44:48Z-
dc.date.available2016-07-20T03:44:48Z-
dc.date.issued2015-
dc.identifier.citationPlos One, 2015, v. 10 n. 9, p. e0135940-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/227850-
dc.description.abstractBackground Photolyases and cryptochromes are evolutionarily related flavoproteins, which however perform distinct physiological functions. Photolyases (PHR) are evolutionarily ancient enzymes. They are activated by light and repair DNA damage caused by UV radiation. Although cryptochromes share structural similarity with DNA photolyases, they lack DNA repair activity. Cryptochrome (CRY) is one of the key elements of the circadian system in animals. In plants, CRY acts as a blue light receptor to entrain circadian rhythms, and mediates a variety of light responses, such as the regulation of flowering and seedling growth. Results We performed a comprehensive evolutionary analysis of the CRY/PHR superfamily. The superfamily consists of 7 major subfamilies: CPD class I and CPD class II photolyases, (6-4) photolyases, CRY-DASH, plant PHR2, plant CRY and animal CRY. Although the whole superfamily evolved primarily under strong purifying selection (average omega = 0.0168), some subfamilies did experience strong episodic positive selection during their evolution. Photolyases were lost in higher animals that suggests natural selection apparently became weaker in the late stage of evolutionary history. The evolutionary time estimates suggested that plant and animal CRYs evolved in the Neoproterozoic Era (similar to 1000-541 Mya), which might be a result of adaptation to the major climate and global light regime changes occurred in that period of the Earth's geological history.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPlos One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEvolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes-
dc.typeArticle-
dc.identifier.emailDvornyk, V: dvornyk@hkucc.hku.hk-
dc.identifier.authorityDvornyk, V=rp00693-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0135940-
dc.identifier.pmid26352435-
dc.identifier.volume10-
dc.identifier.issue9-
dc.identifier.spagee0135940-
dc.identifier.epagee0135940-
dc.identifier.isiWOS:000360932800020-
dc.publisher.placeUnited States-

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