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Article: Comparative Genome Analyses of Serratia marcescens FS14 Reveals Its High Antagonistic Potential

TitleComparative Genome Analyses of Serratia marcescens FS14 Reveals Its High Antagonistic Potential
Authors
Issue Date2015
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2015, v. 10 n. 4, p. e0123061 How to Cite?
AbstractS. marcescensFS14 was isolated from an Atractylodes macrocephala Koidzplant that was infected by Fusarium oxysporum and showed symptoms of root rot. With the completion of the genome sequence of FS14, the first comprehensive comparative-genomic analysis of the Serratia genus was performed. Pan-genome and COG analyses showed that the majority of the conserved core genes are involved in basic cellular functions, while genomic factors such as prophages contribute considerably to genome diversity. Additionally, a Type I restriction-modification system, a Type III secretion system and tellurium resistance genes are found in only some Serratia species. Comparative analysis further identified that S. marcescens FS14 possesses multiple mechanisms for antagonism against other microorganisms, including the production of prodigiosin, bacteriocins, and multi-antibiotic resistant determinants as well as chitinases. The presence of two evolutionarily distinct Type VI secretion systems (T6SSs) in FS14 may provide further competitive advantages for FS14 against other microbes. To our knowledge, this is the first report of comparative analysis on T6SSs in the genus, which identifies four types of T6SSs in Serratia spp.. Competition bioassays of FS14 against the vital plant pathogenic bacterium Ralstonia solanacearum and fungi Fusarium oxysporumand Sclerotinia sclerotiorum were performed to support our genomic analyses, in which FS14 demonstrated high antagonistic activities against both bacterial and fungal phytopathogens.
Persistent Identifierhttp://hdl.handle.net/10722/227830
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, P-
dc.contributor.authorKwok, AHY-
dc.contributor.authorJiang, J-
dc.contributor.authorRan, T-
dc.contributor.authorXu, D-
dc.contributor.authorWang, W-
dc.contributor.authorLeung, FCC-
dc.date.accessioned2016-07-19T09:04:27Z-
dc.date.available2016-07-19T09:04:27Z-
dc.date.issued2015-
dc.identifier.citationPlos One, 2015, v. 10 n. 4, p. e0123061-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/227830-
dc.description.abstractS. marcescensFS14 was isolated from an Atractylodes macrocephala Koidzplant that was infected by Fusarium oxysporum and showed symptoms of root rot. With the completion of the genome sequence of FS14, the first comprehensive comparative-genomic analysis of the Serratia genus was performed. Pan-genome and COG analyses showed that the majority of the conserved core genes are involved in basic cellular functions, while genomic factors such as prophages contribute considerably to genome diversity. Additionally, a Type I restriction-modification system, a Type III secretion system and tellurium resistance genes are found in only some Serratia species. Comparative analysis further identified that S. marcescens FS14 possesses multiple mechanisms for antagonism against other microorganisms, including the production of prodigiosin, bacteriocins, and multi-antibiotic resistant determinants as well as chitinases. The presence of two evolutionarily distinct Type VI secretion systems (T6SSs) in FS14 may provide further competitive advantages for FS14 against other microbes. To our knowledge, this is the first report of comparative analysis on T6SSs in the genus, which identifies four types of T6SSs in Serratia spp.. Competition bioassays of FS14 against the vital plant pathogenic bacterium Ralstonia solanacearum and fungi Fusarium oxysporumand Sclerotinia sclerotiorum were performed to support our genomic analyses, in which FS14 demonstrated high antagonistic activities against both bacterial and fungal phytopathogens.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPlos One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleComparative Genome Analyses of Serratia marcescens FS14 Reveals Its High Antagonistic Potential-
dc.typeArticle-
dc.identifier.emailLeung, FCC: fcleung@hkucc.hku.hk-
dc.identifier.authorityLeung, FCC=rp00731-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0123061-
dc.identifier.pmid25856195-
dc.identifier.volume10-
dc.identifier.issue4-
dc.identifier.spagee0123061-
dc.identifier.epagee0123061-
dc.identifier.isiWOS:000352588500071-
dc.publisher.placeUnited States-

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