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Book: Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II):Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents

TitleAnti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II):Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents
Authors
KeywordsAntineoplastic agents
Cancer -- Chemotherapy
Gold -- Therapeutic use
Issue Date2016
PublisherSpringer
Citation
Zou, T. Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II):Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents. Singapore: Springer. 2016 How to Cite?
AbstractThis thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Persistent Identifierhttp://hdl.handle.net/10722/227764
ISBN
Series/Report no.Springer Theses

 

DC FieldValueLanguage
dc.contributor.authorZou, T-
dc.date.accessioned2016-07-18T09:12:41Z-
dc.date.available2016-07-18T09:12:41Z-
dc.date.issued2016-
dc.identifier.citationZou, T. Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II):Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents. Singapore: Springer. 2016-
dc.identifier.isbn9789811006562-
dc.identifier.urihttp://hdl.handle.net/10722/227764-
dc.description.abstractThis thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol “switch-on” probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofseriesSpringer Theses-
dc.subjectAntineoplastic agents-
dc.subjectCancer -- Chemotherapy-
dc.subjectGold -- Therapeutic use-
dc.titleAnti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II):Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents-
dc.typeBook-
dc.identifier.emailZou, T: zoutt@hku.hk-
dc.identifier.doi10.1007/978-981-10-0657-9-
dc.identifier.hkuros259595-
dc.identifier.spage1-
dc.identifier.epage164-
dc.publisher.placeSingapore-

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