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Article: Ivabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction

TitleIvabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction
Authors
Issue Date2015
PublisherICR Publishers Ltd. The Journal's web site is located at http://www.icr-heart.com/
Citation
The Journal of Heart Value Disease, 2015, v. 24 n. 4, p. 433-435 How to Cite?
AbstractPatients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function.
Persistent Identifierhttp://hdl.handle.net/10722/227379
ISSN
2015 Impact Factor: 0.715
2015 SCImago Journal Rankings: 0.574

 

DC FieldValueLanguage
dc.contributor.authorHuang, D-
dc.contributor.authorChan, PHM-
dc.contributor.authorLam, CC-
dc.contributor.authorShea, PC-
dc.contributor.authorYiu, KH-
dc.contributor.authorTse, HF-
dc.contributor.authorSiu, DCW-
dc.date.accessioned2016-07-18T09:10:08Z-
dc.date.available2016-07-18T09:10:08Z-
dc.date.issued2015-
dc.identifier.citationThe Journal of Heart Value Disease, 2015, v. 24 n. 4, p. 433-435-
dc.identifier.issn0966-8519-
dc.identifier.urihttp://hdl.handle.net/10722/227379-
dc.description.abstractPatients with severe aortic stenosis (AS) and left ventricular systolic dysfunction pose a significant challenge to the managing physician. Conventional pharmacological therapy for systolic heart failure has not been proven beneficial in this setting. Ivabradine, a selective current inhibitor, decreases the spontaneous firing rate of sinoatrial nodal cells, thereby reducing the heart rate, and has been shown to reduce a composite end-point of heart failure hospitalization and mortality in patients with impaired left ventricular function. Herein are reported details of the hemodynamic effects and clinical outcome of ivabradine treatment in an 86-year-old man with severe AS and severe left ventricular systolic function.-
dc.languageeng-
dc.publisherICR Publishers Ltd. The Journal's web site is located at http://www.icr-heart.com/-
dc.relation.ispartofThe Journal of Heart Value Disease-
dc.titleIvabradine in Severe Aortic Stenosis with Poor Left Ventricular Ejection Fraction-
dc.typeArticle-
dc.identifier.emailChan, PHM: phmchan@hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hk-
dc.identifier.authorityChan, PHM=rp01864-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authoritySiu, DCW=rp00534-
dc.identifier.pmid26897811-
dc.identifier.hkuros259697-
dc.identifier.volume24-
dc.identifier.issue4-
dc.identifier.spage433-
dc.identifier.epage435-
dc.publisher.placeUnited Kingdom-

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