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Article: Estimation of replicative senescence via a population dynamics model of cells in culture

TitleEstimation of replicative senescence via a population dynamics model of cells in culture
Authors
KeywordsReplicative senescence
Mathematical model
Stochastic processes
Issue Date2001
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero
Citation
Experimental Gerontology, 2001, v. 36 n. 1, p. 79-88 How to Cite?
AbstractA simple mathematical model is developed for determining the time-varying fraction of senescent cells in culture in terms of the underlying probability distribution of the number of population doublings until senescence. This functional relationship is inverted, which allows for the estimation of the probability distribution of the number of population doublings until senescence given experimental data on the time-varying fraction of senescent cells. The relationship - in particular, the lag - between these two quantities is analyzed under the assumption that the number of population doublings until senescence follows the Weibull distribution. If the number of population doublings until senescence is geometrically distributed (i.e. the Weibull with shape parameter equal to one) then the cell culture appears immortal.
Persistent Identifierhttp://hdl.handle.net/10722/226853
ISSN
2015 Impact Factor: 3.35
2015 SCImago Journal Rankings: 1.620
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWein, LM-
dc.contributor.authorWu, JTK-
dc.date.accessioned2016-07-07T04:22:57Z-
dc.date.available2016-07-07T04:22:57Z-
dc.date.issued2001-
dc.identifier.citationExperimental Gerontology, 2001, v. 36 n. 1, p. 79-88-
dc.identifier.issn0531-5565-
dc.identifier.urihttp://hdl.handle.net/10722/226853-
dc.description.abstractA simple mathematical model is developed for determining the time-varying fraction of senescent cells in culture in terms of the underlying probability distribution of the number of population doublings until senescence. This functional relationship is inverted, which allows for the estimation of the probability distribution of the number of population doublings until senescence given experimental data on the time-varying fraction of senescent cells. The relationship - in particular, the lag - between these two quantities is analyzed under the assumption that the number of population doublings until senescence follows the Weibull distribution. If the number of population doublings until senescence is geometrically distributed (i.e. the Weibull with shape parameter equal to one) then the cell culture appears immortal.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/expgero-
dc.relation.ispartofExperimental Gerontology-
dc.rightsPosting accepted manuscript (postprint): © <2001>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectReplicative senescence-
dc.subjectMathematical model-
dc.subjectStochastic processes-
dc.titleEstimation of replicative senescence via a population dynamics model of cells in culture-
dc.typeArticle-
dc.identifier.emailWu, JTK: joewu@hkucc.hku.hk-
dc.identifier.authorityWu, JTK=rp00517-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0531-5565(00)00187-X-
dc.identifier.pmid11162913-
dc.identifier.scopuseid_2-s2.0-0035192848-
dc.identifier.volume36-
dc.identifier.issue1-
dc.identifier.spage79-
dc.identifier.epage88-
dc.identifier.isiWOS:000166432300007-
dc.publisher.placeUnited States-

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