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Article: Myocardial stiffness as assessed by diastolic wall strain in adult survivors of childhood leukaemias with preserved left ventricular ejection fraction

TitleMyocardial stiffness as assessed by diastolic wall strain in adult survivors of childhood leukaemias with preserved left ventricular ejection fraction
Authors
KeywordsChildhood leukaemia survivors
Diastolic function
Diastolic wall strain
Myocardial stiffness
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org
Citation
European Heart Journal - Cardiovascular Imaging , 2017, v. 18 n. 4, p. 451-458 How to Cite?
AbstractAims We tested the hypothesis that myocardial stiffness as assessed by diastolic wall strain (DWS) is altered in adult survivors of childhood leukaemias with preserved left ventricular (LV) ejection fraction and explored its association with myocardial fibrosis and diastolic deformation. Methods and results Ninety-four (53 males) adult survivors of childhood leukaemias aged 22.2±5.5 years and 66 (36 males) healthy controls were studied retrospectively. Diastolic wall strain and calibrated integrated backscatter (cIB) were measured as indices of myocardial stiffness and fibrosis, respectively. Left and right ventricular (RV) diastolic and torsional mechanics were interrogated using speckle tracking echocardiography. Patients had significantly lower LV DWS, and hence stiffer LV myocardium, and greater myocardial cIB in patients than controls (all P < 0.001). Left ventricular longitudinal, radial, and circumferential early diastolic strain rates, circumferential late diastolic strain rate, and peak twisting and untwisting velocities, tricuspid annular early diastolic velocity, and RV-free wall longitudinal early diastolic strain rate were significantly lower in patients than controls (all P < 0.05). Diastolic wall strain correlated inversely with myocardial cIB, and positively with LV longitudinal, radial, and circumferential early diastolic strain rates (all P < 0.05), while myocardial cIB correlated inversely with LV radial and circumferential early diastolic strain rates, circumferential late diastolic strain rate, peak twisting and untwisting velocities, and tricuspid annular e velocity (all P < 0.05). Conclusion In adult survivors of childhood leukaemias, despite the preservation of LV ejection fraction, increased stiffness of the LV myocardium is evident and is associated with myocardial fibrosis and impaired ventricular diastolic function.
Persistent Identifierhttp://hdl.handle.net/10722/226374
ISSN
2017 Impact Factor: 8.336
2015 SCImago Journal Rankings: 2.044
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, WYV-
dc.contributor.authorCheuk, KLD-
dc.contributor.authorCheng, FWT-
dc.contributor.authorYang, JYK-
dc.contributor.authorYau, JPW-
dc.contributor.authorHo, KKH-
dc.contributor.authorLi, CK-
dc.contributor.authorLi, CH-
dc.contributor.authorYuen, HL-
dc.contributor.authorLing, SC-
dc.contributor.authorChan, GCF-
dc.contributor.authorCheung, YF-
dc.date.accessioned2016-06-17T07:43:43Z-
dc.date.available2016-06-17T07:43:43Z-
dc.date.issued2017-
dc.identifier.citationEuropean Heart Journal - Cardiovascular Imaging , 2017, v. 18 n. 4, p. 451-458-
dc.identifier.issn2047-2404-
dc.identifier.urihttp://hdl.handle.net/10722/226374-
dc.description.abstractAims We tested the hypothesis that myocardial stiffness as assessed by diastolic wall strain (DWS) is altered in adult survivors of childhood leukaemias with preserved left ventricular (LV) ejection fraction and explored its association with myocardial fibrosis and diastolic deformation. Methods and results Ninety-four (53 males) adult survivors of childhood leukaemias aged 22.2±5.5 years and 66 (36 males) healthy controls were studied retrospectively. Diastolic wall strain and calibrated integrated backscatter (cIB) were measured as indices of myocardial stiffness and fibrosis, respectively. Left and right ventricular (RV) diastolic and torsional mechanics were interrogated using speckle tracking echocardiography. Patients had significantly lower LV DWS, and hence stiffer LV myocardium, and greater myocardial cIB in patients than controls (all P < 0.001). Left ventricular longitudinal, radial, and circumferential early diastolic strain rates, circumferential late diastolic strain rate, and peak twisting and untwisting velocities, tricuspid annular early diastolic velocity, and RV-free wall longitudinal early diastolic strain rate were significantly lower in patients than controls (all P < 0.05). Diastolic wall strain correlated inversely with myocardial cIB, and positively with LV longitudinal, radial, and circumferential early diastolic strain rates (all P < 0.05), while myocardial cIB correlated inversely with LV radial and circumferential early diastolic strain rates, circumferential late diastolic strain rate, peak twisting and untwisting velocities, and tricuspid annular e velocity (all P < 0.05). Conclusion In adult survivors of childhood leukaemias, despite the preservation of LV ejection fraction, increased stiffness of the LV myocardium is evident and is associated with myocardial fibrosis and impaired ventricular diastolic function.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://ejechocard.oxfordjournals.org-
dc.relation.ispartofEuropean Heart Journal - Cardiovascular Imaging-
dc.subjectChildhood leukaemia survivors-
dc.subjectDiastolic function-
dc.subjectDiastolic wall strain-
dc.subjectMyocardial stiffness-
dc.titleMyocardial stiffness as assessed by diastolic wall strain in adult survivors of childhood leukaemias with preserved left ventricular ejection fraction-
dc.typeArticle-
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hk-
dc.identifier.emailLing, SC: lingsc@hku.hk-
dc.identifier.emailChan, GCF: gcfchan@hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityChan, GCF=rp00431-
dc.identifier.authorityCheung, YF=rp00382-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ehjci/jew098-
dc.identifier.pmid27166023-
dc.identifier.scopuseid_2-s2.0-85019715753-
dc.identifier.hkuros258695-
dc.identifier.volume18-
dc.identifier.issue4-
dc.identifier.spage451-
dc.identifier.epage458-
dc.identifier.isiWOS:000402099900015-
dc.publisher.placeUnited Kingdom-

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